D-optimal experimental approach for designing topical microemulsion of itraconazole: Characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats

European Journal of Pharmaceutical Sciences

Volumn 67, Issue , 2015, Pages 97-112

  Kumar, Neeraj ^a   Shishu, ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Antigungal; D optimal mixture design; Itraconazole; Microemulsion; Optimization; Tinea pedis

Indexed keywords

CARBOMER; CATALASE; GLUTATHIONE; ITRACONAZOLE; KETOCONAZOLE; MALONALDEHYDE; OCTANOIN; OIL; REACTIVE OXYGEN METABOLITE; SURFACTANT; WATER; ANTIFUNGAL AGENT; EMULSION; LACTATE DEHYDROGENASE; LIPID;

ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG STORAGE; EX VIVO STUDY; FEMALE; FLOW KINETICS; FUNGAL BURDEN SCORE; HISTOPATHOLOGY; HYDROGEL; IN VIVO STUDY; MICROEMULSION; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHARMACODYNAMICS; PRURITUS; RAT; REMISSION; SCORING SYSTEM; SKIN DEFECT; SKIN INFECTION; SKIN REDNESS; TEXTURE ANALYSIS; TINEA PEDIS; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; EMULSION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PH; SKIN; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; TRICHOPHYTON; WISTAR RAT;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIFUNGAL AGENTS; CATALASE; DRUG DESIGN; EMULSIONS; FEMALE; GLUTATHIONE; HYDROGEN-ION CONCENTRATION; ITRACONAZOLE; L-LACTATE DEHYDROGENASE; LIPIDS; RATS, WISTAR; RHEOLOGY; SKIN; SURFACE-ACTIVE AGENTS; TINEA PEDIS; TREATMENT OUTCOME; TRICHOPHYTON;

EID: 84913529186     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.10.014     Document Type: Article

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