Oil based nanocarrier system for transdermal delivery of ropinirole: A mechanistic, pharmacokinetic and biochemical investigation

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 436-444

  Azeem, Adnan ^a   Talegaonkar, Sushama ^b   Negi, Lalit M ^b   Ahmad, Farhan J ^b   Khar, Roop K ^b   Iqbal, Zeenat ^b  

^a Jubilant Life Sciences   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Nanoemulsion gel; Parkinson lesioned brain; Pharmacokinetics; Relative bioavailability; Transdermal

Indexed keywords

CATALASE; GLUTATHIONE; NANOCARRIER; OIL; ROPINIROLE; ROPITOR; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; ENZYME ACTIVITY; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NANOEMULSION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STRATUM CORNEUM; TABLET;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANIMALS; ANTIPARKINSON AGENTS; BIOLOGICAL AVAILABILITY; BRAIN; CALORIMETRY, DIFFERENTIAL SCANNING; CATALASE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIHYDROXYPHENYLALANINE; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; GELS; GLUTATHIONE; INDOLES; MALE; NANOPARTICLES; NANOTECHNOLOGY; OILS; PARKINSONIAN DISORDERS; RATS; RATS, WISTAR; SKIN ABSORPTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84655167749     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.039     Document Type: Article

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