Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-α, iNOS and Cox-2 mRNA expression and blocks NF-κB promoter activity in murine macrophages

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Yamada, Hidetoshi ^a   Kikuchi, Sayaka ^a   Inui, Tomoki ^b   Takahashi, Hideyuki ^a   Kimura, Ken Ichi ^b  

^a IWATE BIOTECHNOLOGY RESEARCH CENTER   (Japan)

^b IWATE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GENTIANA TRIFLORA EXTRACT; GENTIOLACTONE; GENTIOPICRIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PLANT EXTRACT; SECOIRIDOID; SWERTIAMARIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IRIDOID; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG STRUCTURE; FRACTIONATION; GENE EXPRESSION; GENE REPRESSION; GENE TRANSLOCATION; GENTIANA TRIFLORA; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT ROOT; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENETICS; GENTIAN; METABOLISM; PROMOTER REGION;

GENTIANA TRIFLORA; MURINAE;

ANIMALS; CYCLOOXYGENASE 2; GENTIANA; IRIDOIDS; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84912569813     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113834     Document Type: Article

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