Engineering hydrophobically modified chitosan for enhancing the dispersion of respirable microparticles of levofloxacin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 88, Issue 3, 2014, Pages 816-829

  Merchant, Zahra ^a   Taylor, Kevin M G ^a   Stapleton, Paul ^a   Razak, Sana A ^a   Kunda, Nitesh ^b   Alfagih, Iman ^b,c   Sheikh, Khalid ^a   Saleem, Imran Y ^b   Somavarapu, Satyanarayana ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antibiotic; Chitosan; Dry powder inhalation; Pseudomonas aeruginosa; Pulmonary delivery; Spray drying

Indexed keywords

CHITOSAN; LEUCINE; LEVOFLOXACIN; MICROSPHERE;

A549 CELL LINE; ADSORPTION; AEROSOL; ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CHEMICAL ENGINEERING; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; DRY POWDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; LASER DIFFRACTION; LIGHT SCATTERING; MINIMUM INHIBITORY CONCENTRATION; MTT ASSAY; MUCOADHESION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PSEUDOMONAS AERUGINOSA; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; THERMOGRAVIMETRY; X RAY POWDER DIFFRACTION; ZETA POTENTIAL; CHEMICAL PHENOMENA; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; PROCEDURES; SYNTHESIS; X RAY DIFFRACTION;

ADMINISTRATION, INHALATION; CHEMICAL ENGINEERING; CHITOSAN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEVOFLOXACIN; MICROSPHERES; PARTICLE SIZE; PSEUDOMONAS AERUGINOSA; X-RAY DIFFRACTION;

EID: 84912553656     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.09.005     Document Type: Article

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