메뉴 건너뛰기




Volumn 193, Issue 11, 2014, Pages 5420-5433

Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CYTOKINE;

EID: 84912550530     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303359     Document Type: Article
Times cited : (9)

References (55)
  • 2
    • 0028298229 scopus 로고
    • gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
    • Foy, T. M., J. D. Laman, J. A. Ledbetter, A. Aruffo, E. Claassen, and R. J. Noelle. 1994. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180: 157-163.
    • (1994) J. Exp. Med. , vol.180 , pp. 157-163
    • Foy, T.M.1    Laman, J.D.2    Ledbetter, J.A.3    Aruffo, A.4    Claassen, E.5    Noelle, R.J.6
  • 3
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    • Han, S., K. Hathcock, B. Zheng, T. B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155: 556-567.
    • (1995) J. Immunol. , vol.155 , pp. 556-567
    • Han, S.1    Hathcock, K.2    Zheng, B.3    Kepler, T.B.4    Hodes, R.5    Kelsoe, G.6
  • 4
    • 74549156399 scopus 로고    scopus 로고
    • CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses
    • Obar, J. J., M. J. Molloy, E. R. Jellison, T. A. Stoklasek, W. Zhang, E. J. Usherwood, and L. Lefrançois. 2010. CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc. Natl. Acad. Sci. USA 107: 193-198.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 193-198
    • Obar, J.J.1    Molloy, M.J.2    Jellison, E.R.3    Stoklasek, T.A.4    Zhang, W.5    Usherwood, E.J.6    Lefrançois, L.7
  • 5
    • 74549216531 scopus 로고    scopus 로고
    • Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    • Pipkin, M. E., J. A. Sacks, F. Cruz-Guilloty, M. G. Lichtenheld, M. J. Bevan, and A. Rao. 2010. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32: 79-90.
    • (2010) Immunity , vol.32 , pp. 79-90
    • Pipkin, M.E.1    Sacks, J.A.2    Cruz-Guilloty, F.3    Lichtenheld, M.G.4    Bevan, M.J.5    Rao, A.6
  • 6
    • 71849102141 scopus 로고    scopus 로고
    • Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses
    • Wilson, E. B., and A. M. Livingstone. 2008. Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses. J. Immunol. 181: 7445-7448.
    • (2008) J. Immunol. , vol.181 , pp. 7445-7448
    • Wilson, E.B.1    Livingstone, A.M.2
  • 7
    • 84864771090 scopus 로고    scopus 로고
    • Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling
    • Published erratum appears in 2012 J. Leukoc. Biol. 92: 1123
    • Ahmed, K. A., L. Wang, M. A. Munegowda, S. J. Mulligan, J. R. Gordon, P. Griebel, and J. Xiang. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. [Published erratum appears in 2012 J. Leukoc. Biol. 92: 1123.] J. Leukoc. Biol. 92: 289-300.
    • (2012) J. Leukoc. Biol. , vol.92 , pp. 289-300
    • Ahmed, K.A.1    Wang, L.2    Munegowda, M.A.3    Mulligan, S.J.4    Gordon, J.R.5    Griebel, P.6    Xiang, J.7
  • 9
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393: 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van Der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 10
    • 0030848161 scopus 로고    scopus 로고
    • Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help
    • Bennett, S. R., F. R. Carbone, F. Karamalis, J. F. Miller, and W. R. Heath. 1997. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J. Exp. Med. 186: 65-70.
    • (1997) J. Exp. Med. , vol.186 , pp. 65-70
    • Bennett, S.R.1    Carbone, F.R.2    Karamalis, F.3    Miller, J.F.4    Heath, W.R.5
  • 11
    • 0033697454 scopus 로고    scopus 로고
    • CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
    • Schulz, O., A. D. Edwards, M. Schito, J. Aliberti, S. Manickasingham, A. Sher, and C. Reis e Sousa. 2000. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13: 453-462.
    • (2000) Immunity , vol.13 , pp. 453-462
    • Schulz, O.1    Edwards, A.D.2    Schito, M.3    Aliberti, J.4    Manickasingham, S.5    Sher, A.6    Reis E Sousa, C.7
  • 14
    • 0036889420 scopus 로고    scopus 로고
    • Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    • Belz, G. T., D. Wodarz, G. Diaz, M. A. Nowak, and P. C. Doherty. 2002. Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. J. Virol. 76: 12388-12393.
    • (2002) J. Virol. , vol.76 , pp. 12388-12393
    • Belz, G.T.1    Wodarz, D.2    Diaz, G.3    Nowak, M.A.4    Doherty, P.C.5
  • 15
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8 T cell memory
    • Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 16
    • 0029023171 scopus 로고
    • Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene
    • Tripp, R. A., S. R. Sarawar, and P. C. Doherty. 1995. Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene. J. Immunol. 155: 2955-2959.
    • (1995) J. Immunol. , vol.155 , pp. 2955-2959
    • Tripp, R.A.1    Sarawar, S.R.2    Doherty, P.C.3
  • 17
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8 T cell memory following acute infection without CD4 T cell help
    • Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 19
    • 80052038585 scopus 로고    scopus 로고
    • Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells
    • Feau, S., R. Arens, S. Togher, and S. P. Schoenberger. 2011. Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells. Nat. Immunol. 12: 908-913.
    • (2011) Nat. Immunol. , vol.12 , pp. 908-913
    • Feau, S.1    Arens, R.2    Togher, S.3    Schoenberger, S.P.4
  • 20
    • 84884258239 scopus 로고    scopus 로고
    • CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza
    • Ballesteros-Tato, A., B. León, F. E. Lund, and T. D. Randall. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J. Exp. Med. 210: 1591-1601.
    • (2013) J. Exp. Med. , vol.210 , pp. 1591-1601
    • Ballesteros-Tato, A.1    León, B.2    Lund, F.E.3    Randall, T.D.4
  • 21
    • 84863991008 scopus 로고    scopus 로고
    • Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection
    • Brown, D. M., S. Lee, Mde. L. Garcia-Hernandez, and S. L. Swain. 2012. Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection. J. Virol. 86: 6792-6803.
    • (2012) J. Virol. , vol.86 , pp. 6792-6803
    • Brown, D.M.1    Lee, S.2    Garcia-Hernandez, Mde.L.3    Swain, S.L.4
  • 23
    • 84866533018 scopus 로고    scopus 로고
    • Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors
    • Strutt, T. M., K. K. McKinstry, Y. Kuang, L. M. Bradley, and S. L. Swain. 2012. Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc. Natl. Acad. Sci. USA 109: E2551-E2560.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E2551-E2560
    • Strutt, T.M.1    McKinstry, K.K.2    Kuang, Y.3    Bradley, L.M.4    Swain, S.L.5
  • 26
    • 0031897801 scopus 로고    scopus 로고
    • Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
    • Barnden, M. J., J. Allison, W. R. Heath, and F. R. Carbone. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76: 34-40.
    • (1998) Immunol. Cell Biol. , vol.76 , pp. 34-40
    • Barnden, M.J.1    Allison, J.2    Heath, W.R.3    Carbone, F.R.4
  • 27
    • 77949884125 scopus 로고    scopus 로고
    • Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge
    • Thomas, P. G., S. A. Brown, M. Y. Morris, W. Yue, J. So, C. Reynolds, R. J. Webby, and P. C. Doherty. 2010. Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge. J. Immunol. 184: 1721-1727.
    • (2010) J. Immunol. , vol.184 , pp. 1721-1727
    • Thomas, P.G.1    Brown, S.A.2    Morris, M.Y.3    Yue, W.4    So, J.5    Reynolds, C.6    Webby, R.J.7    Doherty, P.C.8
  • 30
    • 0021325943 scopus 로고
    • Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens
    • Tannock, G. A., J. A. Paul, and R. D. Barry. 1984. Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens. Infect. Immun. 43: 457-462.
    • (1984) Infect. Immun. , vol.43 , pp. 457-462
    • Tannock, G.A.1    Paul, J.A.2    Barry, R.D.3
  • 31
    • 79957686777 scopus 로고    scopus 로고
    • CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input
    • Kumamoto, Y., L. M. Mattei, S. Sellers, G.W. Payne, and A. Iwasaki. 2011. CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input. Proc. Natl. Acad. Sci. USA 108: 8749-8754.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8749-8754
    • Kumamoto, Y.1    Mattei, L.M.2    Sellers, S.3    Payne, G.W.4    Iwasaki, A.5
  • 32
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge, J. P., F. Di Rosa, and P. Matzinger. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393: 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 33
  • 34
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 35
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto, F., D. Lenig, R. Förster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Förster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 37
    • 0028123444 scopus 로고
    • CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
    • Seder, R. A., R. N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 179: 299-304.
    • (1994) J. Exp. Med. , vol.179 , pp. 299-304
    • Seder, R.A.1    Germain, R.N.2    Linsley, P.S.3    Paul, W.E.4
  • 38
    • 34848828559 scopus 로고    scopus 로고
    • Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
    • Obst, R., H. M. van Santen, R. Melamed, A. O. Kamphorst, C. Benoist, and D. Mathis. 2007. Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation. Proc. Natl. Acad. Sci. USA 104: 15460-15465.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 15460-15465
    • Obst, R.1    Van Santen, H.M.2    Melamed, R.3    Kamphorst, A.O.4    Benoist, C.5    Mathis, D.6
  • 39
    • 0030846262 scopus 로고    scopus 로고
    • Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells
    • Itoh, Y., and R. N. Germain. 1997. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J. Exp. Med. 186: 757-766.
    • (1997) J. Exp. Med. , vol.186 , pp. 757-766
    • Itoh, Y.1    Germain, R.N.2
  • 40
    • 0028806723 scopus 로고
    • Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
    • Grewal, I. S., J. Xu, and R. A. Flavell. 1995. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378: 617-620.
    • (1995) Nature , vol.378 , pp. 617-620
    • Grewal, I.S.1    Xu, J.2    Flavell, R.A.3
  • 41
    • 0028790434 scopus 로고
    • CD40 ligand-transduced costimulation of T cells in the development of helper function
    • van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378: 620-623.
    • (1995) Nature , vol.378 , pp. 620-623
    • Van Essen, D.1    Kikutani, H.2    Gray, D.3
  • 42
    • 0029861758 scopus 로고    scopus 로고
    • CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection
    • Whitmire, J. K., M. K. Slifka, I. S. Grewal, R. A. Flavell, and R. Ahmed. 1996. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J. Virol. 70: 8375-8381.
    • (1996) J. Virol. , vol.70 , pp. 8375-8381
    • Whitmire, J.K.1    Slifka, M.K.2    Grewal, I.S.3    Flavell, R.A.4    Ahmed, R.5
  • 45
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: Implications for vaccine design
    • Seder, R. A., P. A. Darrah, and M. Roederer. 2008. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8: 247-258.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 46
    • 84906055300 scopus 로고    scopus 로고
    • CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses
    • Olson, M. R., S. G. Seah, K. Edenborough, P. C. Doherty, A. M. Lew, and S. J. Turner. 2014. CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses. Immunol. Cell Biol. 92: 605-611.
    • (2014) Immunol. Cell Biol. , vol.92 , pp. 605-611
    • Olson, M.R.1    Seah, S.G.2    Edenborough, K.3    Doherty, P.C.4    Lew, A.M.5    Turner, S.J.6
  • 47
    • 62049085168 scopus 로고    scopus 로고
    • Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    • Sun, J., R. Madan, C. L. Karp, and T. J. Braciale. 2009. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat. Med. 15: 277-284.
    • (2009) Nat. Med. , vol.15 , pp. 277-284
    • Sun, J.1    Madan, R.2    Karp, C.L.3    Braciale, T.J.4
  • 48
    • 80053086090 scopus 로고    scopus 로고
    • Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells
    • Denton, A. E., B. E. Russ, P. C. Doherty, S. Rao, and S. J. Turner. 2011. Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells. Proc. Natl. Acad. Sci. USA 108: 15306-15311.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 15306-15311
    • Denton, A.E.1    Russ, B.E.2    Doherty, P.C.3    Rao, S.4    Turner, S.J.5
  • 49
    • 50949127683 scopus 로고    scopus 로고
    • Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: Perforin and granzyme B)
    • Araki, Y., M. Fann, R. Wersto, and N. P. Weng. 2008. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J. Immunol. 180: 8102-8108.
    • (2008) J. Immunol. , vol.180 , pp. 8102-8108
    • Araki, Y.1    Fann, M.2    Wersto, R.3    Weng, N.P.4
  • 50
    • 67349169780 scopus 로고    scopus 로고
    • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells
    • Araki, Y., Z. Wang, C. Zang, W. H. Wood, III, D. Schones, K. Cui, T. Y. Roh, B. Lhotsky, R. P. Wersto, W. Peng, et al. 2009. Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity 30: 912-925.
    • (2009) Immunity , vol.30 , pp. 912-925
    • Araki, Y.1    Wang, Z.2    Zang, C.3    Wood, W.H.4    Schones, D.5    Cui, K.6    Roh, T.Y.7    Lhotsky, B.8    Wersto, R.P.9    Peng, W.10
  • 51
    • 79952756708 scopus 로고    scopus 로고
    • Cutting edge: Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status
    • Zediak, V. P., J. B. Johnnidis, E. J. Wherry, and S. L. Berger. 2011. Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status. J. Immunol. 186: 2705-2709.
    • (2011) J. Immunol. , vol.186 , pp. 2705-2709
    • Zediak, V.P.1    Johnnidis, J.B.2    Wherry, E.J.3    Berger, S.L.4
  • 53
    • 8144228277 scopus 로고    scopus 로고
    • Dose response of CRM197 and tetanus toxoid-conjugated Haemophilus influenzae type b vaccines
    • Huebner, R. E., M. Nicol, R. Mothupi, H. Käyhty, N. Mbelle, E. Khomo, and K. P. Klugman. 2004. Dose response of CRM197 and tetanus toxoid-conjugated Haemophilus influenzae type b vaccines. Vaccine 23: 802-806.
    • (2004) Vaccine , vol.23 , pp. 802-806
    • Huebner, R.E.1    Nicol, M.2    Mothupi, R.3    Käyhty, H.4    Mbelle, N.5    Khomo, E.6    Klugman, K.P.7
  • 54
    • 0034797737 scopus 로고    scopus 로고
    • Identification of canine helper T-cell epitopes from the fusion protein of canine distemper virus
    • Ghosh, S., J. Walker, and D. C. Jackson. 2001. Identification of canine helper T-cell epitopes from the fusion protein of canine distemper virus. Immunology 104: 58-66.
    • (2001) Immunology , vol.104 , pp. 58-66
    • Ghosh, S.1    Walker, J.2    Jackson, D.C.3
  • 55
    • 0026703523 scopus 로고
    • Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination
    • Valmori, D., A. Pessi, E. Bianchi, and G. Corradin. 1992. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J. Immunol. 149: 717-721.
    • (1992) J. Immunol. , vol.149 , pp. 717-721
    • Valmori, D.1    Pessi, A.2    Bianchi, E.3    Corradin, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.