Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions

Cytotherapy

Volumn 16, Issue 11, 2014, Pages 1486-1500

  Ylostalo, Joni H ^a   Bartosh, Thomas J ^a   Tiblow, April ^a   Prockop, Darwin J ^a  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

3D; MSC; Pre activation; Sphere; Stem cell; Xeno free

Indexed keywords

BOVINE SERUM ALBUMIN; CD82 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLOOXYGENASE 2; GROWTH DIFFERENTIATION FACTOR 15; HUMAN SERUM ALBUMIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 24; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; LEUKEMIA INHIBITORY FACTOR; MANGANESE SUPEROXIDE DISMUTASE; PARATHYROID HORMONE RECEPTOR; PROSTAGLANDIN E2; SCATTER FACTOR; SECRETED FRIZZLED RELATED PROTEIN 1; TETRAZOLIUM; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR TWIST; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; CULTURE MEDIUM; SERUM ALBUMIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER CELL; CELL ACTIVATION; CELL AGGREGATION; CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MESENCHYMAL STROMA CELL; MIXED LYMPHOCYTE REACTION; PHENOTYPE; PROSTATE CANCER CELL LINE; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SPHEROID CELL; STEM CELL; UPREGULATION; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; IN VITRO STUDY; MULTICELLULAR SPHEROID; PROCEDURES;

CELL DIFFERENTIATION; CELL PROLIFERATION; CULTURE MEDIA; DINOPROSTONE; HUMANS; IN VITRO TECHNIQUES; MESENCHYMAL STROMAL CELLS; SERUM ALBUMIN; SPHEROIDS, CELLULAR;

EID: 84912524584     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2014.07.010     Document Type: Article

References (39)

1. Evans J.B., Syed B.A. New hope for dry AMD?. Nat Rev Drug Discov 2013, 12:501-502.
2. Keating A. Mesenchymal stromal cells: new directions. Cell Stem Cell 2012, 10:709-716.
3. Prockop D.J., Kota D.J., Bazhanov N., Reger R.L. Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). JCell Mol Med 2010, 14:2190-2199.
4. Spees J.L., Gregory C.A., Singh H., Tucker H.A., Peister A., Lynch P.J., et al. Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. Mol Ther 2004, 9:747-756.
5. Francois M., Copland I.B., Yuan S., Romieu-Mourez R., Waller E.K., Galipeau J., et al. Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-gamma licensing. Cytotherapy 2012, 14:147-152.
6. Lee R.H., Yoon N., Reneau J.C., Prockop D.J. Preactivation of human MSCs with TNF-alpha enhances tumor-suppressive activity. Cell Stem Cell 2012, 11:825-835.
7. Waterman R.S., Henkle S.L., Betancourt A.M. Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis. PLoS One 2012, 7:e45590.
8. Betancourt A.M. New cell-based therapy paradigm: induction of bone marrow-derived multipotent mesenchymal stromal cells into pro-inflammatory MSC1 and anti-inflammatory MSC2 phenotypes. adv Biochem Eng Biotechnol 2013, 130:163-197.
9. Waterman R.S., Tomchuck S.L., Henkle S.L., Betancourt A.M. Anew mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One 2010, 5:e10088.
10. Teare D.O., Emmison N., Ton-That C., Bradley R.H. Effects of serum on the kinetics of CHO attachment to ultraviolet-ozone modified polystyrene surfaces. JColloid Interface Sci 2001, 234:84-89.
11. Shen M., Horbett T.A. The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. JBiomed Mater Res 2001, 57:336-345.
12. Achilli T.M., Meyer J., Morgan J.R. Advances in the formation, use and understanding of multi-cellular spheroids. Expert Opin Biol Ther 2012, 12:1347-1360.
13. Page H., Flood P., Reynaud E.G. Three-dimensional tissue cultures: current trends and beyond. Cell Tissue Res 2013, 352:123-131.
14. Qihao Z., Xigu C., Guanghui C., Weiwei Z. Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by co-culture with liver cells. DNA Cell Biol 2007, 26:497-503.
15. Potapova I.A., Doronin S.V., Kelly D.J., Rosen A.B., Schuldt A.J., Lu Z., et al. Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage. Am J Physiol Heart Circ Physiol 2008, 295:H2257-H2263.
16. Potapova I.A., Gaudette G.R., Brink P.R., Robinson R.B., Rosen M.R., Cohen I.S., et al. Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells 2007, 25:1761-1768.
17. Wang C.C., Chen C.H., Hwang S.M., Lin W.W., Huang C.H., Lee W.Y., et al. Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty. Stem Cells 2009, 27:724-732.
18. Wang W., Itaka K., Ohba S., Nishiyama N., Chung U.I., Yamasaki Y., et al. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 2009, 30:2705-2715.
19. Xie Q.P., Huang H., Xu B., Dong X., Gao S.L., Zhang B., et al. Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation 2009, 77:483-491.
20. Frith J.E., Thomson B., Genever P.G. Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 2009, 16:735-749.
21. Saleh F.A., Whyte M., Genever P.G. Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model. Eur Cell Mater 2011, 22:242-257.
22. Saleh F.A., Genever P.G. Turning round: multipotent stromal cells, a three-dimensional revolution?. Cytotherapy 2011, 13:903-912.
23. Jing Y., Jian-Xiong Y. 3-D spheroid culture of bone marrow mesenchymal stem cell of rhesus monkey with improved multi-differentiation potential to epithelial progenitors and neuron in vitro. Clin Exp Ophthalmol 2011, 39:808-819.
24. Baraniak P.R., McDevitt T.C. Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential. Cell Tissue Res 2012, 347:701-711.
25. Suzuki S., Muneta T., Tsuji K., Ichinose S., Makino H., Umezawa A., et al. Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration. Arthritis Res Ther 2012, 14:R136.
26. Isern J., Martin-Antonio B., Ghazanfari R., Martin A.M., Lopez J.A., del Toro R., et al. Self-renewing human bone marrow mesenspheres promote hematopoietic stem cell expansion. Cell Rep 2013, 3:1714-1724.
27. Bartosh T.J., Ylostalo J.H., Bazhanov N., Kuhlman J., Prockop D.J. Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem Cells 2013, 31:2443-2456.
28. Sart S., Tsai A.C., Li Y., Ma T. Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications. Tissue Eng Part B Rev 2013, Dec 13 (Epub ahead of print).
29. Ylostalo J.H., Bartosh T.J., Coble K., Prockop D.J. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells 2012, 30:2283-2296.
30. Bartosh T.J., Ylostalo J.H., Mohammadipoor A., Bazhanov N., Coble K., Claypool K., et al. Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A 2010, 107:13724-13729.
31. Arufe M.C., De la Fuente A., Fuentes-Boquete I., De Toro F.J., Blanco F.J. Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation. JCell Biochem 2009, 108:145-155.
32. Block G.J., Ohkouchi S., Fung F., Frenkel J., Gregory C., Pochampally R., et al. Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells 2009, 27:670-681.
33. Lee R.H., Pulin A.A., Seo M.J., Kota D.J., Ylostalo J., Larson B.L., et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009, 5:54-63.
34. Sekiya I., Larson B.L., Smith J.R., Pochampally R., Cui J.G., Prockop D.J. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002, 20:530-541.
35. Abrahamsson P.A. Neuroendocrine differentiation in prostatic carcinoma. Prostate 1999, 39:135-148.
36. Bernardo M.E., Fibbe W.E. Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 2013, 13:392-402.
37. Spees J.L., Olson S.D., Whitney M.J., Prockop D.J. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 2006, 103:1283-1288.
38. Islam M.N., Das S.R., Emin M.T., Wei M., Sun L., Westphalen K., et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 2012, 18:759-765.
39. Faulkner-Jones A., Greenhough S., King J.A., Gardner J., Courtney A., Shu W. Development of a valve-based cell printer for the formation of human embryonic stem cell spheroid aggregates. Biofabrication 2013, 5:15013-15082.