Elevated vascular level of ortho -Tyrosine contributes to the impairment of insulin-induced arterial relaxation

Hormone and Metabolic Research

Volumn 46, Issue 11, 2014, Pages 749-752

  Szijarto I A ^a,b,c   Molnar G A ^a   Mikolas E ^a   Fisi, V ^a   Cseh, J ^a   Laczy, B ^a   Kovacs T ^a   Boddi K ^d   Takatsy A ^d   Gollasch, M ^b,c   Koller, A ^d,e,f   Wittmann, I ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF PÉCS   (Hungary)

^e NEW YORK MEDICAL COLLEGE   (United States)

^f SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

eNOS; insulin; ortho tyrosine; vasomotor function

Indexed keywords

3 (2 HYDROXYPHENYL)ALANINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PHENYLALANINE; TYROSINE; 2-TYROSINE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISORDERS OF HORMONE METABOLISM; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FEMORAL ARTERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; MALE; NONHUMAN; RAT; SUPPLEMENTATION; VASCULAR DISEASE; VASOMOTOR REFLEX; ANIMAL; CELL CULTURE; DRUG EFFECTS; IN VITRO STUDY; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; IN VITRO TECHNIQUES; INSULIN; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; TYROSINE; VASODILATION;

EID: 84912143684     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1387701     Document Type: Article

References (27)

1. Saltiel A. R., Kahn C. R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature: 2001; 414 799 806
2. Muniyappa R., Montagnani M., Koh K. K., Quon M. J. Cardiovascular actions of insulin. Endocr Rev: 2007; 28 463 491
3. Eringa E. C., Stehouwer C. D., van Nieuw Amerongen G. P., Ouwehand L., Westerhof N., Sipkema P. Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am J Physiol Heart Circ Physiol: 2004; 287 H2043 H2048
4. Steinberg H. O., Brechtel G., Johnson A., Fineberg N., Baron A. D. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest: 1994; 94 1172 1179
5. Lee J. H., Ragolia L.AKT. AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells. Am J Physiol Cell Physiol: 2006; 291 C1355 C1365
6. Forstermann U., Sessa W. C. Nitric oxide synthases: regulation and function. European heart journal: 2012; 33 829 837 837a-837d
7. Houstis N., Rosen E. D., Lander E. S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature: 2006; 440 944 948
8. Bagi Z., Koller A., Kaley G. Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol: 2003; 285 H1404 H1410
9. Bagi Z., Koller A. Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. J Vasc Res: 2003; 40 47 57
10. Pieper G. M., Langenstroer P., Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res: 1997; 34 145 156
11. Pennathur S., Wagner J. D., Leeuwenburgh C., Litwak K. N., Heinecke J. W. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. J Clin Invest: 2001; 107 853 860
12. Biondi R., Ambrosio G., Liebgott T., Cardounel A. J., Bettini M., Tritto I., Zweier J. L. Hydroxylation of D-phenylalanine as a novel approach to detect hydroxyl radicals: application to cardiac pathophysiology. Cardiovasc Res: 2006; 71 322 330
13. Molnar G. A., Nemes V., Biro Z., Ludany A., Wagner Z., Wittmann I. Accumulation of the hydroxyl free radical markers meta-, ortho-tyrosine and DOPA in cataractous lenses is accompanied by a lower protein and phenylalanine content of the water-soluble phase. Free Radic Res: 2005; 39 1359 1366
14. Molnar G. A., Wagner Z., Marko L., Ko Szegi T., Mohas M., Kocsis B., Matus Z., Wagner L., Tamasko M., Mazak I., Laczy B., Nagy J., Wittmann I. Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production. Kidney Int: 2005; 68 2281 2287
15. Gurer-Orhan H., Ercal N., Mare S., Pennathur S., Orhan H., Heinecke J. W. Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids. Biochem J: 2006; 395 277 284
16. Bertin C., Weston L. A., Huang T., Jander G., Owens T., Meinwald J., Schroeder F. C. Grass roots chemistry: meta-tyrosine, an herbicidal nonprotein amino acid. Proc Natl Acad Sci USA: 2007; 104 16964 16969
17. Klipcan L., Moor N., Kessler N., Safro M. G. Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine. Proc Natl Acad Sci USA: 2009; 106 11045 11048
18. Szijarto I. A., Molnar G. A., Mikolas E., Fisi V., Laczy B., Gollasch M., Koller A., Wittmann I. Increase in insulin-induced relaxation of consecutive arterial segments toward the periphery: Role of vascular oxidative state. Free Radic Res: 2014; 48 749 757
19. Mikolas E., Kun S., Laczy B., Molnar G. A., Selley E., Koszegi T., Wittmann I. Incorporation of ortho- and meta-tyrosine into cellular proteins leads to erythropoietin-resistance in an erythroid cell line. Kidney Blood Press Res: 2013; 38 217 225
20. Ruggiero R. A., Bruzzo J., Chiarella P., Bustuoabad O. D., Meiss R. P., Pasqualini C. D. Concomitant tumor resistance: the role of tyrosine isomers in the mechanisms of metastases control. Cancer Res: 2012; 72 1043 1050
21. Fesus G., Dubrovska G., Gorzelniak K., Kluge R., Huang Y., Luft F. C., Gollasch M. Adiponectin is a novel humoral vasodilator. Cardiovasc Res: 2007; 75 719 727
22. Wagner L., Laczy B., Tamasko M., Mazak I., Marko L., Molnar G. A., Wagner Z., Mohas M., Cseh J., Fekete A., Wittmann I. Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C. Endothelium: 2007; 14 245 255
23. Vivekanadan-Giri A., Wang J. H., Byun J., Pennathur S. Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage. Rev Endocr Metab Disord: 2008; 9 275 287
24. Karam L. R., Simic M. G. Formation of ortho-tyrosine by radiation and organic solvents in chicken tissue. J Biol Chem: 1990; 265 11581 11585
25. Ledo A., Arduini A., Asensi M. A., Sastre J., Escrig R., Brugada M., Aguar M., Saenz P., Vento M. Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants. Am J Clin Nutr: 2009; 89 210 215
26. Onorato J. M., Thorpe S. R., Baynes J. W. Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. Annals of the New York Academy of Sciences: 1998; 854 277 290
27. Kun S., Mikolas E., Molnar G. A., Selley E., Laczy B., Csiky B., Kovacs T., Wittmann I. Association of plasma ortho-tyrosine/para-tyrosine ratio with responsiveness of erythropoiesis-stimulating agent in dialyzed patients. Redox Rep: 2014; 19 190 198