Misincorporation of free m-tyrosine into cellular proteins: A potential cytotoxic mechanism for oxidized amino acids

Biochemical Journal

Volumn 395, Issue 2, 2006, Pages 277-284

  Gurer Orhan, Hande ^a   Ercal, Nuran ^b   Mare, Suneetha ^b   Pennathur, Subramaniam ^c   Orhan, Hilmi ^a   Heinecke, Jay W ^c  

^a HACETTEPE UNIVERSITY   (Turkey)

^b MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Amino acid misincorporation; Hydroxyl radical; m tyrosine; Oxidative stress; Protein synthesis; tRNA synthetase

Indexed keywords

AMINO ACIDS; CELL CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SYNTHESIS (CHEMICAL); TISSUE;

CHINESE-HAMSTER OVARY (CHO); L-PHENYLALANINE; TANDEM MASS SPECTROMETRIC ANALYSIS;

PROTEINS;

CELL PROTEIN; CYCLOHEXIMIDE; META TYROSINE; 3 TYROSINE; 3-TYROSINE; CARBON; PHENYLALANINE; PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RNA TRANSLATION; ANIMAL; CELL CULTURE; CELL DEATH; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; HAMSTER; METABOLISM; OXIDATION REDUCTION REACTION; SPECTROSCOPY;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

ANIMALS; CARBON RADIOISOTOPES; CELL DEATH; CELLS, CULTURED; CHO CELLS; CRICETINAE; CYCLOHEXIMIDE; OXIDATION-REDUCTION; PHENYLALANINE; PROTEIN BIOSYNTHESIS; PROTEINS; SPECTRUM ANALYSIS; TRANSCRIPTION, GENETIC; TYROSINE;

EID: 33645797343     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051964     Document Type: Article

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