Anti-inflammation effects of naloxone involve phosphoinositide 3-kinase delta and gamma

Journal of Surgical Research

Volumn 192, Issue 2, 2014, Pages 599-606

  Wang, Tao Yeuan ^a,b   Su, Nuan Yen ^a   Shih, Ping Cheng ^c,d   Tsai, Pei Shan ^e   Huang, Chun Jen ^c,d  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c Taipei Tzu Chi Hospital   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chemokine; Cytokine; Endotoxin; Macrophages; Naloxone; NF B

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; CYCLOOXYGENASE 2; ENDOTOXIN; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; NALOXONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOINOSITIDE 3 KINASE DELTA; PROSTAGLANDIN E2; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; NARCOTIC ANTAGONIST; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CD PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; IC50; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; ENDOTOXEMIA; ENZYME ACTIVATION; IMMUNOLOGY; INFLAMMATION; METABOLISM; TRANSFORMED CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TRANSFORMED; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; ENDOTOXEMIA; ENZYME ACTIVATION; INFLAMMATION; MACROPHAGES; MICE; NALOXONE; NARCOTIC ANTAGONISTS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84912125708     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.06.022     Document Type: Article

References (31)

1. Bradberry JC, Raebel MA. Continuous infusion of naloxone in the treatment of narcotic overdose. Drug Intell Clin Pharm 1981;15:945.
2. Miller RR, Menke JA, Hansen NB, Zwick DL, Bickers RG, Nowicki PT. The effect of naloxone on the hemodynamics of the newborn piglet with septic shock. Pediatr Res 1986;20:707.
3. Law WR, Ferguson JL. Naloxone alters organ perfusion during endotoxin shock in conscious rats. Am J Physiol 1988;255:H1106.
4. Chuang GJ, Gao CX, Mulder DS, Chiu RC. Prevention of septic ventilatory depression with naloxone. Arch Surg 1987;122:940.
5. Raymond RM, Harkema JM, Stoffs WV, Emerson TE Jr. Effects of naloxone therapy on hemodynamics and metabolism following a superlethal dosage of Escherichia coli endotoxin in dogs. Surg Gynecol Obstet 1981;152:159.
6. Jan WC, Chen CH, Hsu K, Tsai PS, Huang CJ. L-type calcium channels and m-opioid receptors are involved in mediating the anti-inflammatory effects of naloxone. J Surg Res 2011;167:e263.
7. Holaday JW, Faden AI. Naloxone reverses the pathophysiology of shock through an antagonism of endorphin systems. Adv Biochem Psychopharmacol 1981;28:421.
8. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655.
9. Fruman DA, Bismuth G. Fine tuning the immune response with PI3K. Immunol Rev 2009;228:253.
10. Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124.
11. Schabbauer G, Tencati M, Pedersen B, Pawlinski R, Mackman N. PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol 2004;24:1963.
12. Chantry D, Vojtek A, Kashishian A, et al. p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 1997;272:19236.
13. Durand CA, Hartvigsen K, Fogelstrand L, et al. Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol 2009;183:5673.
14. Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol 2000;10:466.
15. Hirsch E, Lembo G, Montrucchio G, Rommel C, Costa C, Barberis L. Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb Haemost 2006;95:29.
16. Fung-Leung WP. Phosphoinositide 3-kinase delta ( PI3Kδ) in leukocyte signaling and function. Cell Signal 2011;23:603.
17. Jiang Q, Akashi S, Miyake K, Petty HR. Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B. J Immunol 2000;165:3541.
18. Yang H, Young DW, Gusovsky F, Chow JC. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J Biol Chem 2000;275:20861.
19. Huang YH, Tsai PS, Huang CJ. Bupivacaine inhibits COX-2 expression, PGE2, and cytokine production in endotoxin-activated macrophages. Acta Anaesthesiol Scand 2008;52:530.
20. Su NY, Peng TC, Tsai PS, Huang CJ. Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate. J Surg Res 2013;185:726.
21. Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 2003;170:2647.
22. Shugg RP, Thomson A, Tanabe N, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem 2013;288:35346.
23. Chen CP, Tsai PS, Huang CJ. Antiinflammation effect of human placental multipotent mesenchymal stromal cells is mediated by prostaglandin E2 via a myeloid differentiation primary response gene 88-dependent pathway. Anesthesiology 2012;117:568.
24. Sadhu C, Dick K, Tino WT, Staunton DE. Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun 2003;308:764.
25. Hawkins PT, Stephens LR. PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis. Science 2007;318:64.
26. Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol 2010;10:1017.
27. Blair LA, Bence-Hanulec KK, Mehta S, Franke T, Kaplan D, Marshall J. Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J Neurosci 1999;19:1940.
28. Lu Z, Ballou LM, Jiang YP, Cohen IS, Lin RZ. Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-ι. J Cardiovasc Pharmacol 2011;58:439.
29. Le Blanc C, Mironneau C, Barbot C, et al. Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate. Circ Res 2004;95:300.
30. Zhou X, Yang W, Li J. Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem 2006;281:31337.
31. Li XQ, Cao W, Li T, et al. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol 2009;9:1032.