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Volumn 20, Issue 42, 2014, Pages 15564-15579

Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies

Author keywords

Biomarkers; Chemoradiation; Chemotherapy; Neoadjuvant therapy; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CA 19-9 ANTIGEN; DIHYDROPYRIMIDINE DEHYDROGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; MOLECULAR MARKER; OSTEONECTIN; SMAD4 PROTEIN; THYMIDYLATE SYNTHASE; UNTRANSLATED RNA;

EID: 84912122765     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i42.15564     Document Type: Article
Times cited : (38)

References (109)
  • 1
    • 84912112719 scopus 로고    scopus 로고
    • World Cancer Research Fund International. Available from: URL
    • World Cancer Research Fund International. Pancreatic Cancer. 2013. Available from: URL: Http://www.wcrf.org/cancer-statistics/data-specific-cancers/pancreatic-cancer-s tatistics.php
    • (2013) Pancreatic Cancer.
  • 2
    • 84896542182 scopus 로고    scopus 로고
    • American Cancer Society. Available from: URL
    • American Cancer Society. Key Statistics about Pancreatic Cancer. 2013. Available from: URL: Http://www.cancer. org/cancer/pancreaticcancer/detailedguide/pancreaticcancer-key-statistics
    • (2013) Key Statistics about Pancreatic Cancer
  • 4
    • 77955101033 scopus 로고    scopus 로고
    • The role of radiotherapy in multimodal treatment of pancreatic carcinoma
    • PMID: 20615227
    • Brunner TB, Scott-Brown M. The role of radiotherapy in multimodal treatment of pancreatic carcinoma. Radiat Oncol 2010; 5: 64 [PMID: 20615227 DOI: 10.1186/1748-717X-5-64]
    • (2010) Radiat Oncol , vol.5 , pp. 64
    • Brunner, T.B.1    Scott-Brown, M.2
  • 5
    • 49749128110 scopus 로고    scopus 로고
    • Neoadjuvant therapy for pancreatic cancer
    • PMID: 18259825
    • Lowy AM. Neoadjuvant therapy for pancreatic cancer. J Gastrointest Surg 2008; 12: 1600-1608 [PMID: 18259825 DOI: 10.1007/s11605-008-0482-2]
    • (2008) J Gastrointest Surg , vol.12 , pp. 1600-1608
    • Lowy, A.M.1
  • 6
    • 33747507299 scopus 로고    scopus 로고
    • One thousand consecutive pancreaticoduodenectomies
    • PMID: 16794383
    • Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006; 244: 10-15 [PMID: 16794383 DOI: 10.1097/01. sla.0000217673.04165.ea]
    • (2006) Ann Surg , vol.244 , pp. 10-15
    • Cameron, J.L.1    Riall, T.S.2    Coleman, J.3    Belcher, K.A.4
  • 7
    • 0021867923 scopus 로고
    • Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection
    • PMID: 4015380
    • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985; 120: 899-903 [PMID: 4015380 DOI: 10.1001/archsurg.1985.01390320023003]
    • (1985) Arch Surg , vol.120 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 10
    • 79955841030 scopus 로고    scopus 로고
    • Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial
    • PMID: 21499862
    • Regine WF, Winter KA, Abrams R, Safran H, Hoffman JP, Konski A, Benson AB, Macdonald JS, Rich TA, Willett CG. Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial. Ann Surg Oncol 2011; 18: 1319-1326 [PMID: 21499862 DOI: 10.1245/s10434-011-1630-6]
    • (2011) Ann Surg Oncol , vol.18 , pp. 1319-1326
    • Regine, W.F.1    Winter, K.A.2    Abrams, R.3    Safran, H.4    Hoffman, J.P.5    Konski, A.6    Benson, A.B.7    Macdonald, J.S.8    Rich, T.A.9    Willett, C.G.10
  • 13
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group
    • discussion 782-4 [PMID: 10615932
    • Klinkenbijl JH, Jeekel J, Sahmoud T, van Pel R, Couvreur ML, Veenhof CH, Arnaud JP, Gonzalez DG, de Wit LT, Hennipman A, Wils J. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 1999; 230: 776-82; discussion 782-4 [PMID: 10615932]
    • (1999) Ann Surg , vol.230 , pp. 776-782
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3    Van Pel, R.4    Couvreur, M.L.5    Veenhof, C.H.6    Arnaud, J.P.7    Gonzalez, D.G.8    De Wit, L.T.9    Hennipman, A.10    Wils, J.11
  • 14
    • 0031925359 scopus 로고    scopus 로고
    • Gemcitabine-A safety review
    • PMID: 9625429
    • Aapro MS, Martin C, Hatty S. Gemcitabine-A safety review. Anticancer Drugs 1998; 9: 191-201 [PMID: 9625429 DOI: 10.10 97/00001813-199803000-00001]
    • (1998) Anticancer Drugs , vol.9 , pp. 191-201
    • Aapro, M.S.1    Martin, C.2    Hatty, S.3
  • 22
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • PMID: 18987634
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8: 967-975 [PMID: 18987634 DOI: 10.1038/nrc2540]
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 23
    • 58149383101 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: Results of a prospective phase II trial
    • PMID: 19092346
    • Heinrich S, Schäfer M, Weber A, Hany TF, Bhure U, Pestalozzi BC, Clavien PA. Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: Results of a prospective phase II trial. Ann Surg 2008; 248: 1014-1022 [PMID: 19092346 DOI: 10.1097/SLA.0b013e318190a6da]
    • (2008) Ann Surg , vol.248 , pp. 1014-1022
    • Heinrich, S.1    Schäfer, M.2    Weber, A.3    Hany, T.F.4    Bhure, U.5    Pestalozzi, B.C.6    Clavien, P.A.7
  • 24
    • 80052906307 scopus 로고    scopus 로고
    • Role of radiation therapy in patients with resectable pancreatic cancer
    • 727 [PMID: 21874833
    • Palta M, Willett C, Czito B. Role of radiation therapy in patients with resectable pancreatic cancer. Oncology (Williston Park) 2011; 25: 715-21, 727 [PMID: 21874833]
    • (2011) Oncology (Williston Park) , vol.25 , pp. 715-21
    • Palta, M.1    Willett, C.2    Czito, B.3
  • 25
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages
    • PMID: 20422030
    • Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. PLoS Med 2010; 7: E1000267 [PMID: 20422030 DOI: 10.1371/journal.pmed.1000267]
    • (2010) PLoS Med , vol.7 , pp. e1000267
    • Gillen, S.1    Schuster, T.2    Meyer Zum Büschenfelde, C.3    Friess, H.4    Kleeff, J.5
  • 26
    • 34548801429 scopus 로고    scopus 로고
    • Multimodality therapy for pancreatic cancer in the U.S.: Utilization, outcomes, and the effect of hospital volume
    • PMID: 17654662
    • Bilimoria KY, Bentrem DJ, Ko CY, Tomlinson JS, Stewart AK, Winchester DP, Talamonti MS. Multimodality therapy for pancreatic cancer in the U.S.: Utilization, outcomes, and the effect of hospital volume. Cancer 2007; 110: 1227-1234 [PMID: 17654662 DOI: 10.1002/cncr.22916]
    • (2007) Cancer , vol.110 , pp. 1227-1234
    • Bilimoria, K.Y.1    Bentrem, D.J.2    Ko, C.Y.3    Tomlinson, J.S.4    Stewart, A.K.5    Winchester, D.P.6    Talamonti, M.S.7
  • 31
    • 84896542066 scopus 로고    scopus 로고
    • Neoadjuvant radiation therapy and its impact on complications after pancreaticoduodenectomy for pancreatic cancer: Analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)
    • PMID: 24112766
    • Cho SW, Tzeng CW, Johnston WC, Cassera MA, Newell PH, Hammill CW, Wolf RF, Aloia TA, Hansen PD. Neoadjuvant radiation therapy and its impact on complications after pancreaticoduodenectomy for pancreatic cancer: Analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). HPB (Oxford) 2014; 16: 350-356 [PMID: 24112766 DOI: 10.1111/hpb.12141]
    • (2014) HPB (Oxford) , vol.16 , pp. 350-356
    • Cho, S.W.1    Tzeng, C.W.2    Johnston, W.C.3    Cassera, M.A.4    Newell, P.H.5    Hammill, C.W.6    Wolf, R.F.7    Aloia, T.A.8    Hansen, P.D.9
  • 34
    • 40949164329 scopus 로고    scopus 로고
    • Efficacy of preoperative radiochemotherapy in patients with locally advanced pancreatic carcinoma
    • PMID: 17882555
    • Lind PA, Isaksson B, Almström M, Johnsson A, Albiin N, Byström P, Permert J. Efficacy of preoperative radiochemotherapy in patients with locally advanced pancreatic carcinoma. Acta Oncol 2008; 47: 413-420 [PMID: 17882555 DOI: 10.1080/02841860701592384]
    • (2008) Acta Oncol , vol.47 , pp. 413-420
    • Lind, P.A.1    Isaksson, B.2    Almström, M.3    Johnsson, A.4    Albiin, N.5    Byström, P.6    Permert, J.7
  • 35
    • 80054108983 scopus 로고    scopus 로고
    • Does the interval from imaging to operation affect the rate of unanticipated metastasis encountered during operation for pancreatic adenocarcinoma?
    • PMID: 22000171
    • Glant JA, Waters JA, House MG, Zyromski NJ, Nakeeb A, Pitt HA, Lillemoe KD, Schmidt CM. Does the interval from imaging to operation affect the rate of unanticipated metastasis encountered during operation for pancreatic adenocarcinoma? Surgery 2011; 150: 607-616 [PMID: 22000171 DOI: 10.1016/j.surg.2011.07.048]
    • (2011) Surgery , vol.150 , pp. 607-616
    • Glant, J.A.1    Waters, J.A.2    House, M.G.3    Zyromski, N.J.4    Nakeeb, A.5    Pitt, H.A.6    Lillemoe, K.D.7    Schmidt, C.M.8
  • 38
    • 77749240353 scopus 로고    scopus 로고
    • Neoadjuvant therapy for pancreatic cancer: A current review
    • PMID: 20187063
    • Abbott DE, Baker MS, Talamonti MS. Neoadjuvant therapy for pancreatic cancer: A current review. J Surg Oncol 2010; 101: 315-320 [PMID: 20187063 DOI: 10.1002/jso.21469]
    • (2010) J Surg Oncol , vol.101 , pp. 315-320
    • Abbott, D.E.1    Baker, M.S.2    Talamonti, M.S.3
  • 41
    • 58149236551 scopus 로고    scopus 로고
    • Histopathological response to preoperative chemoradiation for resectable pancreatic adenocarcinoma: The French Phase II FFCD 9704-SFRO Trial
    • PMID: 19060585
    • Le Scodan R, Mornex F, Partensky C, Mercier C, Valette PJ, Ychou M, Roy P, Scoazec JY. Histopathological response to preoperative chemoradiation for resectable pancreatic adenocarcinoma: The French Phase II FFCD 9704-SFRO Trial. Am J Clin Oncol 2008; 31: 545-552 [PMID: 19060585 DOI: 10.1097/COC.0b013e318172d5c5]
    • (2008) Am J Clin Oncol , vol.31 , pp. 545-552
    • Le Scodan, R.1    Mornex, F.2    Partensky, C.3    Mercier, C.4    Valette, P.J.5    Ychou, M.6    Roy, P.7    Scoazec, J.Y.8
  • 42
    • 0035127288 scopus 로고    scopus 로고
    • The role of apoptosis in 2',2'-difluoro-2'-deoxycytidine (gemcitabine)-mediated radiosensitization
    • PMID: 11234886
    • Lawrence TS, Davis MA, Hough A, Rehemtulla A. The role of apoptosis in 2',2'-difluoro-2'-deoxycytidine (gemcitabine)-mediated radiosensitization. Clin Cancer Res 2001; 7: 314-319 [PMID: 11234886]
    • (2001) Clin Cancer Res , vol.7 , pp. 314-319
    • Lawrence, T.S.1    Davis, M.A.2    Hough, A.3    Rehemtulla, A.4
  • 46
    • 80051546169 scopus 로고    scopus 로고
    • NeoGemTax: Gemcitabine and docetaxel as neoadjuvant treatment for locally advanced nonmetastasized pancreatic cancer
    • PMID: 21523499
    • Sahora K, Kuehrer I, Schindl M, Koelblinger C, Goetzinger P, Gnant M. NeoGemTax: Gemcitabine and docetaxel as neoadjuvant treatment for locally advanced nonmetastasized pancreatic cancer. World J Surg 2011; 35: 1580-1589 [PMID: 21523499 DOI: 10.1007/s00268-011-1113-8]
    • (2011) World J Surg , vol.35 , pp. 1580-1589
    • Sahora, K.1    Kuehrer, I.2    Schindl, M.3    Koelblinger, C.4    Goetzinger, P.5    Gnant, M.6
  • 48
    • 33947415681 scopus 로고    scopus 로고
    • Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. A multi-centre prospectively randomised phase II-study of the Interdisciplinary Working Group Gastrointestinal Tumours (AIO, ARO, and CAO)
    • PMID: 17338829
    • Brunner TB, Grabenbauer GG, Meyer T, Golcher H, Sauer R, Hohenberger W. Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. A multi-centre prospectively randomised phase II-study of the Interdisciplinary Working Group Gastrointestinal Tumours (AIO, ARO, and CAO). BMC Cancer 2007; 7: 41 [PMID: 17338829 DOI: 10.1186/1471-2407-7-41]
    • (2007) BMC Cancer , vol.7 , pp. 41
    • Brunner, T.B.1    Grabenbauer, G.G.2    Meyer, T.3    Golcher, H.4    Sauer, R.5    Hohenberger, W.6
  • 52
    • 84872760142 scopus 로고    scopus 로고
    • Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer
    • PMID: 22744973
    • Shinoto M, Yamada S, Yasuda S, Imada H, Shioyama Y, Honda H, Kamada T, Tsujii H, Saisho H. Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer. Cancer 2013; 119: 45-51 [PMID: 22744973 DOI: 10.1002/cncr.27723]
    • (2013) Cancer , vol.119 , pp. 45-51
    • Shinoto, M.1    Yamada, S.2    Yasuda, S.3    Imada, H.4    Shioyama, Y.5    Honda, H.6    Kamada, T.7    Tsujii, H.8    Saisho, H.9
  • 53
    • 84858710945 scopus 로고    scopus 로고
    • Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 Gy) and intraoperative radiation therapy (15 Gy) in patients with primarily resectable pancreatic cancer -NEOPANC
    • PMID: 22443802
    • Roeder F, Timke C, Saleh-Ebrahimi L, Schneider L, Hackert T, Hartwig W, Kopp-Schneider A, Hensley FW, Buechler MW, Debus J, Huber PE, Werner J. Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 Gy) and intraoperative radiation therapy (15 Gy) in patients with primarily resectable pancreatic cancer -NEOPANC. BMC Cancer 2012; 12: 112 [PMID: 22443802 DOI: 10.1186/1471-2407-12-112]
    • (2012) BMC Cancer , vol.12 , pp. 112
    • Roeder, F.1    Timke, C.2    Saleh-Ebrahimi, L.3    Schneider, L.4    Hackert, T.5    Hartwig, W.6    Kopp-Schneider, A.7    Hensley, F.W.8    Buechler, M.W.9    Debus, J.10    Huber, P.E.11    Werner, J.12
  • 54
    • 1542269125 scopus 로고    scopus 로고
    • The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors
    • PMID: 15075664
    • Schöffski P. The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs 2004; 15: 85-106 [PMID: 15075664 DOI: 10.1097/00001813-200402000-00001]
    • (2004) Anticancer Drugs , vol.15 , pp. 85-106
    • Schöffski, P.1
  • 57
    • 84891490998 scopus 로고    scopus 로고
    • Biomarkers for pancreatic cancer: Promising new markers and options beyond CA 19-9
    • PMID: 23949878
    • Ballehaninna UK, Chamberlain RS. Biomarkers for pancreatic cancer: Promising new markers and options beyond CA 19-9. Tumour Biol 2013; 34: 3279-3292 [PMID: 23949878 DOI: 10.1007/s13277-013-1033-3]
    • (2013) Tumour Biol , vol.34 , pp. 3279-3292
    • Ballehaninna, U.K.1    Chamberlain, R.S.2
  • 59
  • 60
  • 61
    • 34548580650 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
    • PMID: 17390066
    • Mori R, Ishikawa T, Ichikawa Y, Taniguchi K, Matsuyama R, Ueda M, Fujii Y, Endo I, Togo S, Danenberg PV, Shimada H. Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep 2007; 17: 1201-1205 [PMID: 17390066]
    • (2007) Oncol Rep , vol.17 , pp. 1201-1205
    • Mori, R.1    Ishikawa, T.2    Ichikawa, Y.3    Taniguchi, K.4    Matsuyama, R.5    Ueda, M.6    Fujii, Y.7    Endo, I.8    Togo, S.9    Danenberg, P.V.10    Shimada, H.11
  • 62
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • PMID: 15501974
    • Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, Cass C, Lai R, Mackey JR. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004; 10: 6956-6961 [PMID: 15501974 DOI: 10.1158/1078-0432.CCR-04-0224]
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3    Dabbagh, L.4    Young, J.D.5    Dumontet, C.6    Cass, C.7    Lai, R.8    Mackey, J.R.9
  • 64
    • 79960023038 scopus 로고    scopus 로고
    • Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer
    • PMID: 21264835
    • Kim R, Tan A, Lai KK, Jiang J, Wang Y, Rybicki LA, Liu X. Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer. Cancer 2011; 117: 3126-3134 [PMID: 21264835 DOI: 10.1002/cncr.25883]
    • (2011) Cancer , vol.117 , pp. 3126-3134
    • Kim, R.1    Tan, A.2    Lai, K.K.3    Jiang, J.4    Wang, Y.5    Rybicki, L.A.6    Liu, X.7
  • 65
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of action and clinical strategies
    • PMID: 12724731
    • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer 2003; 3: 330-338 [PMID: 12724731 DOI: 10.1038/nrc1074]
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 66
    • 33747169515 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency: Impact of pharmacogenetics on 5-fluorouracil therapy
    • PMID: 16163233
    • Lee A, Ezzeldin H, Fourie J, Diasio R. Dihydropyrimidine dehydrogenase deficiency: Impact of pharmacogenetics on 5-fluorouracil therapy. Clin Adv Hematol Oncol 2004; 2: 527-532 [PMID: 16163233]
    • (2004) Clin Adv Hematol Oncol , vol.2 , pp. 527-532
    • Lee, A.1    Ezzeldin, H.2    Fourie, J.3    Diasio, R.4
  • 67
    • 67651089739 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers
    • PMID: 19571608
    • Shimoda M, Sawada T, Kubota K. Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers. Pathobiology 2009; 76: 193-198 [PMID: 19571608 DOI: 10.1159/000218335]
    • (2009) Pathobiology , vol.76 , pp. 193-198
    • Shimoda, M.1    Sawada, T.2    Kubota, K.3
  • 68
    • 65449177682 scopus 로고    scopus 로고
    • Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis
    • PMID: 19020767
    • Fukui Y, Oka T, Nagayama S, Danenberg PV, Danenberg KD, Fukushima M. Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. Int J Mol Med 2008; 22: 709-716 [PMID: 19020767]
    • (2008) Int J Mol Med , vol.22 , pp. 709-716
    • Fukui, Y.1    Oka, T.2    Nagayama, S.3    Danenberg, P.V.4    Danenberg, K.D.5    Fukushima, M.6
  • 69
    • 53149090560 scopus 로고    scopus 로고
    • High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1
    • PMID: 18309485
    • Kuramochi H, Hayashi K, Uchida K, Nakajima G, Hatori T, Danenberg KD, Danenberg PV, Yamamoto M. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Cancer Chemother Pharmacol 2008; 63: 85-89 [PMID: 18309485 DOI: 10.1007/s00280-008-0714-x]
    • (2008) Cancer Chemother Pharmacol , vol.63 , pp. 85-89
    • Kuramochi, H.1    Hayashi, K.2    Uchida, K.3    Nakajima, G.4    Hatori, T.5    Danenberg, K.D.6    Danenberg, P.V.7    Yamamoto, M.8
  • 70
    • 0141678071 scopus 로고    scopus 로고
    • Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
    • PMID: 14519641
    • Hu YC, Komorowski RA, Graewin S, Hostetter G, Kallioniemi OP, Pitt HA, Ahrendt SA. Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer. Clin Cancer Res 2003; 9: 4165-4171 [PMID: 14519641]
    • (2003) Clin Cancer Res , vol.9 , pp. 4165-4171
    • Hu, Y.C.1    Komorowski, R.A.2    Graewin, S.3    Hostetter, G.4    Kallioniemi, O.P.5    Pitt, H.A.6    Ahrendt, S.A.7
  • 72
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • PMID: 11560969
    • Arteaga CL. The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001; 19: 32S-40S [PMID: 11560969]
    • (2001) J Clin Oncol , vol.19 , pp. 32S-40S
    • Arteaga, C.L.1
  • 73
    • 0037010091 scopus 로고    scopus 로고
    • Epidermal growth factor receptortargeted therapy for pancreatic cancer
    • PMID: 12422311
    • Xiong HQ, Abbruzzese JL. Epidermal growth factor receptortargeted therapy for pancreatic cancer. Semin Oncol 2002; 29: 31-37 [PMID: 12422311 DOI: 10.1016/S0093-7754(02)70088-2]
    • (2002) Semin Oncol , vol.29 , pp. 31-37
    • Xiong, H.Q.1    Abbruzzese, J.L.2
  • 74
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • PMID: 8317885
    • Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993; 13: 565-569 [PMID: 8317885]
    • (1993) Anticancer Res , vol.13 , pp. 565-569
    • Yamanaka, Y.1    Friess, H.2    Kobrin, M.S.3    Buchler, M.4    Beger, H.G.5    Korc, M.6
  • 75
    • 84862080029 scopus 로고    scopus 로고
    • Gemcitabine Overcomes Erlotinib Resistance in EGFR-Overexpressing Cancer Cells through Downregulation of Akt
    • PMID: 21850211
    • Bartholomeusz C, Yamasaki F, Saso H, Kurisu K, Hortobagyi GN, Ueno NT. Gemcitabine Overcomes Erlotinib Resistance in EGFR-Overexpressing Cancer Cells through Downregulation of Akt. J Cancer 2011; 2: 435-442 [PMID: 21850211 DOI: 10.7150/jca.2.435]
    • (2011) J Cancer , vol.2 , pp. 435-442
    • Bartholomeusz, C.1    Yamasaki, F.2    Saso, H.3    Kurisu, K.4    Hortobagyi, G.N.5    Ueno, N.T.6
  • 76
    • 84856567551 scopus 로고    scopus 로고
    • Continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib enhances antitumor activity of chemotherapy in erlotinib-resistant tumor xenografts
    • PMID: 22209766
    • Iwai T, Moriya Y, Shirane M, Fujimoto-Ouchi K, Mori K. Continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib enhances antitumor activity of chemotherapy in erlotinib-resistant tumor xenografts. Oncol Rep 2012; 27: 923-928 [PMID: 22209766]
    • (2012) Oncol Rep , vol.27 , pp. 923-928
    • Iwai, T.1    Moriya, Y.2    Shirane, M.3    Fujimoto-Ouchi, K.4    Mori, K.5
  • 80
    • 0023637227 scopus 로고
    • Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer
    • PMID: 3308077
    • Tempero MA, Uchida E, Takasaki H, Burnett DA, Steplewski Z, Pour PM. Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer. Cancer Res 1987; 47: 5501-5503 [PMID: 3308077]
    • (1987) Cancer Res , vol.47 , pp. 5501-5503
    • Tempero, M.A.1    Uchida, E.2    Takasaki, H.3    Burnett, D.A.4    Steplewski, Z.5    Pour, P.M.6
  • 81
    • 0031242791 scopus 로고    scopus 로고
    • Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas
    • PMID: 9367020
    • Montgomery RC, Hoffman JP, Riley LB, Rogatko A, Ridge JA, Eisenberg BL. Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 1997; 4: 551-556 [PMID: 9367020 DOI: 10.1007/BF02305535]
    • (1997) Ann Surg Oncol , vol.4 , pp. 551-556
    • Montgomery, R.C.1    Hoffman, J.P.2    Riley, L.B.3    Rogatko, A.4    Ridge, J.A.5    Eisenberg, B.L.6
  • 82
    • 0019428714 scopus 로고
    • Specific antigen in serum of patients with colon carcinoma
    • PMID: 6163212
    • Koprowski H, Herlyn M, Steplewski Z, Sears HF. Specific antigen in serum of patients with colon carcinoma. Science 1981; 212: 53-55 [PMID: 6163212 DOI: 10.1126/science. 6163212]
    • (1981) Science , vol.212 , pp. 53-55
    • Koprowski, H.1    Herlyn, M.2    Steplewski, Z.3    Sears, H.F.4
  • 84
    • 0033988823 scopus 로고    scopus 로고
    • A multispecialty approach to the diagnosis and management of pancreatic cancer
    • PMID: 10638554
    • Hawes RH, Xiong Q, Waxman I, Chang KJ, Evans DB, Abbruzzese JL. A multispecialty approach to the diagnosis and management of pancreatic cancer. Am J Gastroenterol 2000; 95: 17-31 [PMID: 10638554 DOI: 10.1111/j.1572-0241.2000.01699. x]
    • (2000) Am J Gastroenterol , vol.95 , pp. 17-31
    • Hawes, R.H.1    Xiong, Q.2    Waxman, I.3    Chang, K.J.4    Evans, D.B.5    Abbruzzese, J.L.6
  • 85
    • 84889089502 scopus 로고    scopus 로고
    • Preoperative CEA and CA 19-9 are prognostic markers for survival after curative resection for ductal adenocarcinoma of the pancreas -A retrospective tumor marker prognostic study
    • PMID: 24161419
    • Distler M, Pilarsky E, Kersting S, Grützmann R. Preoperative CEA and CA 19-9 are prognostic markers for survival after curative resection for ductal adenocarcinoma of the pancreas -A retrospective tumor marker prognostic study. Int J Surg 2013; 11: 1067-1072 [PMID: 24161419 DOI: 10.1016/j.ijsu.2013.10.005]
    • (2013) Int J Surg , vol.11 , pp. 1067-1072
    • Distler, M.1    Pilarsky, E.2    Kersting, S.3    Grützmann, R.4
  • 86
    • 84906351265 scopus 로고    scopus 로고
    • The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients
    • PMID: 24114022
    • Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y. The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients. Surg Today 2014; 44: 1692-1701 [PMID: 24114022 DOI: 10.1007/s00595-013-0752-9]
    • (2014) Surg Today , vol.44 , pp. 1692-1701
    • Kanda, M.1    Fujii, T.2    Takami, H.3    Suenaga, M.4    Inokawa, Y.5    Yamada, S.6    Nakayama, G.7    Sugimoto, H.8    Koike, M.9    Nomoto, S.10    Kodera, Y.11
  • 92
    • 77951050647 scopus 로고    scopus 로고
    • SPARC mRNA expression as a prognostic marker for pancreatic adenocarcinoma patients
    • PMID: 20393008
    • Miyoshi K, Sato N, Ohuchida K, Mizumoto K, Tanaka M. SPARC mRNA expression as a prognostic marker for pancreatic adenocarcinoma patients. Anticancer Res 2010; 30: 867-871 [PMID: 20393008]
    • (2010) Anticancer Res , vol.30 , pp. 867-871
    • Miyoshi, K.1    Sato, N.2    Ohuchida, K.3    Mizumoto, K.4    Tanaka, M.5
  • 95
    • 77951933403 scopus 로고    scopus 로고
    • SMAD4: A predictive marker of PDAC cell permissiveness for oncolytic infection with parvovirus H-1PV
    • PMID: 19856310
    • Dempe S, Stroh-Dege AY, Schwarz E, Rommelaere J, Dinsart C. SMAD4: A predictive marker of PDAC cell permissiveness for oncolytic infection with parvovirus H-1PV. Int J Cancer 2010; 126: 2914-2927 [PMID: 19856310]
    • (2010) Int J Cancer , vol.126 , pp. 2914-2927
    • Dempe, S.1    Stroh-Dege, A.Y.2    Schwarz, E.3    Rommelaere, J.4    Dinsart, C.5
  • 96
    • 80054000870 scopus 로고    scopus 로고
    • The Smad family and its role in pancreatic cancer
    • PMID: 21921337
    • Singh P, Wig JD, Srinivasan R. The Smad family and its role in pancreatic cancer. Indian J Cancer 2010; 48: 351-360 [PMID: 21921337 DOI: 10.4103/0019-509X.84939]
    • (2010) Indian J Cancer , vol.48 , pp. 351-360
    • Singh, P.1    Wig, J.D.2    Srinivasan, R.3
  • 98
    • 84862757239 scopus 로고    scopus 로고
    • Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer
    • PMID: 22321641
    • Malkoski SP, Wang XJ. Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer. FEBS Lett 2012; 586: 1984-1992 [PMID: 22321641 DOI: 10.1016/j.febslet.2012.01.054]
    • (2012) FEBS Lett , vol.586 , pp. 1984-1992
    • Malkoski, S.P.1    Wang, X.J.2
  • 99
    • 84855740089 scopus 로고    scopus 로고
    • A comprehensive examination of Smad4, Smad6 and Smad7 mRNA expression in pancreatic ductal adenocarcinoma
    • PMID: 21768661
    • Singh P, Wig JD, Srinivasan R, Radotra BD. A comprehensive examination of Smad4, Smad6 and Smad7 mRNA expression in pancreatic ductal adenocarcinoma. Indian J Cancer 2011; 48: 170-174 [PMID: 21768661 DOI: 10.4103/0019-509X.82876]
    • (2011) Indian J Cancer , vol.48 , pp. 170-174
    • Singh, P.1    Wig, J.D.2    Srinivasan, R.3    Radotra, B.D.4
  • 100
    • 84881357000 scopus 로고    scopus 로고
    • Prospects of miRNAbased therapy for pancreatic cancer
    • PMID: 23834151
    • Pai P, Rachagani S, Are C, Batra SK. Prospects of miRNAbased therapy for pancreatic cancer. Curr Drug Targets 2013; 14: 1101-1109 [PMID: 23834151 DOI: 10.2174/1389450111314 9990181]
    • (2013) Curr Drug Targets , vol.14 , pp. 1101-1109
    • Pai, P.1    Rachagani, S.2    Are, C.3    Batra, S.K.4
  • 101
    • 33846283385 scopus 로고    scopus 로고
    • The evolution of gene regulation by transcription factors and microRNAs
    • PMID: 17230196
    • Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet 2007; 8: 93-103 [PMID: 17230196 DOI: 10.1038/nrg1990]
    • (2007) Nat Rev Genet , vol.8 , pp. 93-103
    • Chen, K.1    Rajewsky, N.2
  • 102
    • 84855359334 scopus 로고    scopus 로고
    • A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT
    • PMID: 22045191
    • Bryant JL, Britson J, Balko JM, Willian M, Timmons R, Frolov A, Black EP. A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT. Br J Cancer 2012; 106: 148-156 [PMID: 22045191 DOI: 10.1038/bjc.2011.465]
    • (2012) Br J Cancer , vol.106 , pp. 148-156
    • Bryant, J.L.1    Britson, J.2    Balko, J.M.3    Willian, M.4    Timmons, R.5    Frolov, A.6    Black, E.P.7
  • 103
    • 84875890253 scopus 로고    scopus 로고
    • HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    • PMID: 22614017
    • Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 2013; 32: 1616-1625 [PMID: 22614017 DOI: 10.1038/onc.2012.193]
    • (2013) Oncogene , vol.32 , pp. 1616-1625
    • Kim, K.1    Jutooru, I.2    Chadalapaka, G.3    Johnson, G.4    Frank, J.5    Burghardt, R.6    Kim, S.7    Safe, S.8
  • 105
    • 63749130819 scopus 로고    scopus 로고
    • Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    • PMID: 19237629
    • Dong X, Jiao L, Li Y, Evans DB, Wang H, Hess KR, Abbruzzese JL, Li D. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol 2009; 27: 1592-1599 [PMID: 19237629 DOI: 10.1200/JCO.2008.20.1111]
    • (2009) J Clin Oncol , vol.27 , pp. 1592-1599
    • Dong, X.1    Jiao, L.2    Li, Y.3    Evans, D.B.4    Wang, H.5    Hess, K.R.6    Abbruzzese, J.L.7    Li, D.8
  • 106
    • 34250816847 scopus 로고    scopus 로고
    • A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: Gemcitabine alone versus gemcitabine combined with cisplatin
    • PMID: 17453298
    • Palmer DH, Stocken DD, Hewitt H, Markham CE, Hassan AB, Johnson PJ, Buckels JA, Bramhall SR. A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: Gemcitabine alone versus gemcitabine combined with cisplatin. Ann Surg Oncol 2007; 14: 2088-2096 [PMID: 17453298 DOI: 10.1245/s10434-007-9384-x]
    • (2007) Ann Surg Oncol , vol.14 , pp. 2088-2096
    • Palmer, D.H.1    Stocken, D.D.2    Hewitt, H.3    Markham, C.E.4    Hassan, A.B.5    Johnson, P.J.6    Buckels, J.A.7    Bramhall, S.R.8
  • 107
    • 45149091560 scopus 로고    scopus 로고
    • Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head
    • PMID: 18487569
    • Heinrich S, Pestalozzi BC, Schäfer M, Weber A, Bauerfeind P, Knuth A, Clavien PA. Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008; 26: 2526-2531 [PMID: 18487569 DOI: 10.1200/JCO.2007.15.5556]
    • (2008) J Clin Oncol , vol.26 , pp. 2526-2531
    • Heinrich, S.1    Pestalozzi, B.C.2    Schäfer, M.3    Weber, A.4    Bauerfeind, P.5    Knuth, A.6    Clavien, P.A.7
  • 108
    • 77957126838 scopus 로고    scopus 로고
    • Neoadjuvant docetaxel-based chemoradiation for resectable adenocarcinoma of the pancreas: New neoadjuvant regimen was safe and provided an interesting pathologic response
    • PMID: 20828979
    • Turrini O, Ychou M, Moureau-Zabotto L, Rouanet P, Giovannini M, Moutardier V, Azria D, Delpero JR, Viret F. Neoadjuvant docetaxel-based chemoradiation for resectable adenocarcinoma of the pancreas: New neoadjuvant regimen was safe and provided an interesting pathologic response. Eur J Surg Oncol 2010; 36: 987-992 [PMID: 20828979 DOI: 10.1016/j.ejso.2010.07.003]
    • (2010) Eur J Surg Oncol , vol.36 , pp. 987-992
    • Turrini, O.1    Ychou, M.2    Moureau-Zabotto, L.3    Rouanet, P.4    Giovannini, M.5    Moutardier, V.6    Azria, D.7    Delpero, J.R.8    Viret, F.9
  • 109
    • 77952028206 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine plus radiotherapy versus gemcitabine, 5-fluorouracil, and cisplatin followed by radiotherapy and 5-fluorouracil for patients with locally advanced, potentially resectable pancreatic adenocarcinoma
    • PMID: 20461765
    • Landry J, Catalano PJ, Staley C, Harris W, Hoffman J, Talamonti M, Xu N, Cooper H, Benson AB. Randomized phase II study of gemcitabine plus radiotherapy versus gemcitabine, 5-fluorouracil, and cisplatin followed by radiotherapy and 5-fluorouracil for patients with locally advanced, potentially resectable pancreatic adenocarcinoma. J Surg Oncol 2010; 101: 587-592 [PMID: 20461765 DOI: 10.1002/jso.21527]
    • (2010) J Surg Oncol , vol.101 , pp. 587-592
    • Landry, J.1    Catalano, P.J.2    Staley, C.3    Harris, W.4    Hoffman, J.5    Talamonti, M.6    Xu, N.7    Cooper, H.8    Benson, A.B.9


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