NeoGemTax: Gemcitabine and Docetaxel as Neoadjuvant Treatment for Locally Advanced Nonmetastasized Pancreatic Cancer

World Journal of Surgery

Volumn 35, Issue 7, 2011, Pages 1580-1589

  Sahora, Klaus ^a   Kuehrer, Irene ^a   Schindl, Martin ^a   Koelblinger, Claus ^a   Goetzinger, Peter ^a   Gnant, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; DOCETAXEL; DRUG DERIVATIVE; GEMCITABINE; TAXOID;

ADENOCARCINOMA; ADJUVANT THERAPY; AGED; ARTICLE; CANCER STAGING; CLINICAL TRIAL; FEMALE; HUMAN; MALE; MIDDLE AGED; MORTALITY; PANCREAS TUMOR; PATHOLOGY; PHASE 2 CLINICAL TRIAL; PROSPECTIVE STUDY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEOXYCYTIDINE; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PROSPECTIVE STUDIES; TAXOIDS;

EID: 80051546169     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-011-1113-8     Document Type: Conference Paper

References (39)

1. J Ferlay P Autier M Boniol, et al. 2007 Estimates of the cancer incidence and mortality in Europe in 2006 Ann Oncol 18 581 592 17287242 10.1093/annonc/mdl498 1:STN:280:DC%2BD2s7hslSgtw%3D%3D (Pubitemid 46359643)
2. A Jemal T Murray E Ward, et al. 2005 Cancer statistics, 2005 CA Cancer J Clin 55 10 30 15661684 10.3322/canjclin.55.1.10 (Pubitemid 40310185)
3. MH Katz PW Pisters DB Evans, et al. 2008 Borderline resectable pancreatic cancer: the importance of this emerging stage of disease J Am Coll Surg 206 833 846 18471707 10.1016/j.jamcollsurg.2007.12.020 discussion 846-838
4. HA Burris 3rd MJ Moore J Andersen, et al. 1997 Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403 2413 9196156 1:CAS:528:DyaK2sXlsFKksLY%3D (Pubitemid 27251144)
5. A Sultana C Tudur Smith D Cunningham, et al. 2007 Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy Br J Cancer 96 1183 1190 17406358 10.1038/sj.bjc.6603719 1:CAS:528:DC%2BD2sXkt1Gqtb4%3D (Pubitemid 46625082)
6. A Montero F Fossella G Hortobagyi, et al. 2005 Docetaxel for treatment of solid tumours: a systematic review of clinical data Lancet Oncol 6 229 239 15811618 10.1016/S1470-2045(05)70094-2 1:CAS:528:DC%2BD2MXjtlWjtLk%3D (Pubitemid 40450714)
7. K Ridwelski J Fahlke R Kuhn, et al. 2006 Multicenter phase-I/II study using a combination of gemcitabine and docetaxel in metastasized and unresectable, locally advanced pancreatic carcinoma Eur J Surg Oncol 32 3 297 302 16414235 10.1016/j.ejso.2005.11.020 1:STN:280:DC%2BD287lvF2lsw%3D%3D
8. MP Callery KJ Chang EK Fishman, et al. 2009 Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement Ann Surg Oncol 16 1727 1733 19396496 10.1245/s10434-009-0408-6
9. AR Padhani L Ollivier 2001 The RECIST (Response Evaluation Criteria in Solid Tumors) criteria: implications for diagnostic radiologists Br J Radiol 74 983 986 11709461 1:STN:280:DC%2BD3MnmtlKhtw%3D%3D (Pubitemid 33121128)
10. WP Longmire Jr RK Tompkins LW Traverso, et al. 1978 The surgical treatment of pancreatic disease Jpn J Surg 8 249 260 732048 10.1007/BF02469407 (Pubitemid 9107373)
11. LW Traverso WP Longmire Jr 1978 Preservation of the pylorus in pancreaticoduodenectomy Surg Gynecol Obstet 146 959 962 653575 1:STN:280:DyaE1c7otFShtw%3D%3D (Pubitemid 8352062)
12. WG Watson 1950 The surgical treatment of pancreatic and bile duct tumors Pa Med J 53 700 702 15430125 1:STN:280:DyaG3c%2FjvFOmtQ%3D%3D
13. AO Whipple 1949 An evaluation of radical surgery for carcinoma of the pancreas and ampullary region Ann Intern Med 31 624 627 15390535 1:STN:280:DyaG3c%2FgtVWltQ%3D%3D
14. CM Kang JY Kim GH Choi, et al. 2007 The use of adjusted preoperative CA 19-9 to predict the recurrence of resectable pancreatic cancer J Surg Res 140 31 35 17418869 10.1016/j.jss.2006.10.007 1:CAS:528:DC%2BD2sXkvFOqsrs%3D (Pubitemid 46669540)
15. Greene FL, Page DL, Fleming ID et al (2002) AJCC cancer staging manual, 6th edn. Springer, New York
16. S Gillen T Schuster C Meyer Zum Buschenfelde, et al. 2010 Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages PLoS Med 7 4 e1000267 20422030 10.1371/journal.pmed.1000267
17. RR White EK Paulson KS Freed, et al. 2001 Staging of pancreatic cancer before and after neoadjuvant chemoradiation J Gastrointest Surg 5 626 633 12086901 10.1016/S1091-255X(01)80105-0 1:STN:280:DC%2BD38zkt1CqsA%3D%3D (Pubitemid 33651269)
18. YE Kim MS Park HS Hong, et al. 2009 Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation of resectability and staging in patients with pancreatic head cancer Radiology 250 758 765 19164113 10.1148/radiol.2502080501
19. M Choi LK Heilbrun R Venkatramanamoorthy, et al. 2010 Using 18F-fluorodeoxyglucose positron emission tomography to monitor clinical outcomes in patients treated with neoadjuvant chemo-radiotherapy for locally advanced pancreatic cancer Am J Clin Oncol 33 257 261 19806035
20. S Heinrich M Schafer A Weber, et al. 2008 Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: results of a prospective phase II trial Ann Surg 248 1014 1022 19092346 10.1097/SLA.0b013e318190a6da
21. KE Todd B Gloor JS Lane, et al. 1998 Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole J Gastrointest Surg 2 159 166 9834413 10.1016/S1091-255X(98)80008-5 1:STN:280:DyaK1M%2FlvF2mtA%3D%3D (Pubitemid 128432028)
22. WH Isacoff JK Bendetti JJ Barstis, et al. 2007 Phase II trial of infusional fluorouracil, leucovorin, mitomycin, and dipyridamole in locally advanced unresectable pancreatic adenocarcinoma: SWOG S9700 J Clin Oncol 25 1665 1669 17470859 10.1200/JCO.2006.06.7637 1:CAS:528:DC%2BD2sXlvFyktb4%3D (Pubitemid 46797945)
23. M Reni S Cereda G Balzano, et al. 2009 Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma Cancer Chemother Pharmacol 64 6 1253 1259 19381632 10.1007/s00280-009-0995-8 1:CAS:528:DC%2BD1MXhtVWhsrrM
24. A Brade J Brierley A Oza, et al. 2007 Concurrent gemcitabine and radiotherapy with and without neoadjuvant gemcitabine for locally advanced unresectable or resected pancreatic cancer: a phase I-II study Int J Radiat Oncol Biol Phys 67 1027 1036 17197132 10.1016/j.ijrobp.2006.10.015 1:CAS:528:DC%2BD2sXisVWisLo%3D
25. HJ Kim K Czischke MF Brennan, et al. 2002 Does neoadjuvant chemoradiation downstage locally advanced pancreatic cancer? J Gastrointest Surg 6 763 769 12399067 10.1016/S1091-255X(02)00017-3 (Pubitemid 40433496)
26. S Heinrich BC Pestalozzi M Schafer, et al. 2008 Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head J Clin Oncol 26 2526 2531 18487569 10.1200/JCO.2007.15.5556 1:CAS:528:DC%2BD1cXnsVKhurc%3D
27. BD Todd 1988 Pancreatic carcinoma and low serum testosterone: a correlation secondary to cancer cachexia? Eur J Surg Oncol 14 199 202 3371470 1:STN:280:DyaL1c3isFeluw%3D%3D
28. H Snady H Bruckner A Cooperman, et al. 2000 Survival advantage of combined chemoradiotherapy compared with resection as the initial treatment of patients with regional pancreatic carcinoma. An outcomes trial Cancer 89 314 327 10918161 10.1002/1097-0142(20000715)89:2<314::AID-CNCR16>3.0.CO;2-V 1:STN:280:DC%2BD3czptlSjtg%3D%3D (Pubitemid 30489879)
29. S Kastl T Brunner O Herrmann, et al. 2000 Neoadjuvant radio-chemotherapy in advanced primarily non-resectable carcinomas of the pancreas Eur J Surg Oncol 26 578 582 11034809 10.1053/ejso.2000.0950 1:STN:280:DC%2BD3M%2FhvVCktA%3D%3D
30. HJ Wanebo AS Glicksman MP Vezeridis, et al. 2000 Preoperative chemotherapy, radiotherapy, and surgical resection of locally advanced pancreatic cancer Arch Surg 135 81 87 10636353 10.1001/archsurg.135.1.81 1:STN:280:DC%2BD3c7gtVejug%3D%3D discussion 88 (Pubitemid 30043986)
31. JB Ammori LM Colletti MM Zalupski, et al. 2003 Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas J Gastrointest Surg 7 766 772 13129554 10.1016/S1091-255X(03)00113-6 (Pubitemid 37103131)
32. R Wilkowski M Thoma C Bruns, et al. 2006 Chemoradiotherapy with gemcitabine and continuous 5-FU in patients with primary inoperable pancreatic cancer JOP 7 349 360 16832132 (Pubitemid 44083106)
33. A Sa Cunha A Rault C Laurent, et al. 2005 Surgical resection after radiochemotherapy in patients with unresectable adenocarcinoma of the pancreas J Am Coll Surg 201 359 365 16125068 10.1016/j.jamcollsurg.2005.04.008 (Pubitemid 41206773)
34. P Massucco L Capussotti A Magnino, et al. 2006 Pancreatic resections after chemoradiotherapy for locally advanced ductal adenocarcinoma: analysis of perioperative outcome and survival Ann Surg Oncol 13 1201 1208 16955382 10.1245/s10434-006-9032-x (Pubitemid 44440421)
35. X Adhoute D Smith V Vendrely, et al. 2006 Subsequent resection of locally advanced pancreatic carcinoma after chemoradiotherapy Gastroenterol Clin Biol 30 224 230 16565654 10.1016/S0399-8320(06)73157-8
36. H Golcher T Brunner G Grabenbauer, et al. 2008 Preoperative chemoradiation in adenocarcinoma of the pancreas. A single centre experience advocating a new treatment strategy Eur J Surg Oncol 34 756 764 18191528 1:STN:280:DC%2BD1czovVKitA%3D%3D
37. JD Allendorf M Lauerman A Bill, et al. 2008 Neoadjuvant chemotherapy and radiation for patients with locally unresectable pancreatic adenocarcinoma: feasibility, efficacy, and survival J Gastrointest Surg 12 91 100 17786524 10.1007/s11605-007-0296-7
38. JK Bjerregaard MB Mortensen HA Jensen, et al. 2009 Long-term results of concurrent radiotherapy and UFT in patients with locally advanced pancreatic cancer Radiother Oncol 92 226 230 19435643 10.1016/j.radonc.2009.04.010
39. K Sahora I Kuehrer A Eisenhut, et al. 2011 NeoGemOx: Gemcitabine and oxaliplatin as neoadjuvant treatment for locally advanced, nonmetastasized pancreatic cancer Surgery 149 311 320 20817204 10.1016/j.surg.2010.07.048