microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 10, 2014, Pages 6871-6879

  Sun, Niuniu ^a   Ye, Lin ^a   Chang, Tingmin ^a   Li, Xiaojing ^a,b   Li, Xiumin ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

^b Henan Nursing Vocational College   (China)

Author keywords

Cell division cycle 42; Esophageal squamous cell carcinoma; MicroRNA 195; Prognosis; Real time quantitative PCR

Indexed keywords

MESSENGER RNA; MICRORNA; MIRN195 MICRORNA, HUMAN; PROTEIN CDC42; TUMOR MARKER;

AGED; CANCER STAGING; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CHI SQUARE DISTRIBUTION; DISEASE COURSE; DISEASE FREE SURVIVAL; ENZYMOLOGY; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KAPLAN MEIER METHOD; MALE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CDC42 GTP-BINDING PROTEIN; CELL DIFFERENTIATION; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICRORNAS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84912120422     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Zhang Y. Epidemiology of esophageal cancer. World J Gastroenterol 2013; 19: 5598-5606.
3. Shimizu M, Zaninotto G, Nagata K, Graham DY, Lauwers GY. Esophageal squamous cell carcinoma with special reference to its early stage. Best Pract Res Clin Gastroenterol 2013; 27: 171-186.
4. Nakajima M, Kato H. Treatment options for es-ophageal squamous cell carcinoma. Expert Opin Pharmacother 2013; 14: 1345-1354.
5. Mayne GC, Hussey DJ, Watson DI. MicroRNAs and esophageal cancer--implications for path-ogenesis and therapy. Curr Pharm Des 2013; 19: 1211-1226.
6. Ebert MS, Sharp PA. Roles for microRNAs in co-nferring robustness to biological processes. Cell 2012; 149: 515-524.
7. Mendell JT, Olson EN. MicroRNAs in stress signaling and human disease. Cell 2012; 148: 1172-1187.
8. Esquela-Kerscher A, Slack FJ. Oncomirs-micro-RNAswith a role in cancer. Nat Rev Cancer 2006; 6: 259-269.
9. Zang W, Wang Y, Du Y. Differential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma. Tumor Biol 2014; 35: 3295-3304
10. Yang G, Wu D, Zhu J. Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1. Oncol Rep 2013; 30: 877-889.
11. Zhou Y, Jiang H, Gu J. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. Cell Death Dis 2013; 4: e695.
12. Liu M, Lang N, Qiu M. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int J Cancer 2011; 128: 1269-1279.
13. Xu T, Zhu Y, Xiong Y. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 2009; 50: 113-121.
14. Jiang HL, Yu H, Ma X. MicroRNA-195 regulates steroid receptor coactivator-3 protein expression in hepatocellular carcinoma cells. Tumour Biol 2014; 35: 6955-60.
15. Wang L, Qian L, Li X, Yan J. MicroRNA-195 inhibits colorectal cancer cell proliferation, colony formation and invasion through targeting CARMA3. Mol Med Rep 2014; 10: 473-8.
16. Chabre O, Libé R, Assie G. Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients. Endocr Re-lat Cancer 2013; 20: 579-594.
17. Yongchun Z, Linwei T, Xicai W. MicroRNA-195 inhibits non-small cell lung cancer cell proliferation, migration and invasion by targeting MYB. Cancer Lett 2014; 347: 65-74.
18. Wang Y, Chen H, Fu Y. MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN. Int J Clin Exp Pathol 2013; 6: 2824-2834.
19. Fu MG, Li S, Yu TT. Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42. FEBS Lett 2013; 587: 3471-3479.
20. Fu HL, Wu de P, Wang XF. Altered miRNA expression is associated with differentiation, invasion, and metastasis of esophageal squamous cell carcinoma (ESCC) in patients from Huaian, China. Cell Biochem Biophys 2013; 67: 657-668.
21. Zins K, Lucas T, Reichl P, Abraham D, Aharinejad S. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One 2013; 8: e74924.
22. Mao JH, Zhou RP, Peng AF. microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN. Oncol Lett 2012; 4: 1125-1129.
23. Yang X, Yu J, Yin J. MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2. Pharmazie 2012; 67: 645-651.
24. Jia LF, Wei SB, Gong K, Gan YH, Yu GY. Prognostic implications of micoRNA miR-195 expression in human tongue squamous cell carcinoma. PLoS One 2013; 8: e56634.
25. Heneghan HM, Miller N, Lowery AJ. Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg 2010; 251: 499-505.
26. Ma J, Xue Y, Liu W. Role of activated rac1/cdc-42 in mediating endothelial cell proliferation and tumor angiogenesis in breast cancer. PLoS One 2013; 8: e66275.
27. Chen Q, Chen X, Zhang M. miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42. Dig Dis Sci 2011; 56: 2009-2016.
28. Li Y, Zhu X, Xu W, Wang D, Yan J. miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. Biochem Biophys Res Commun 2013; 431: 560-565.
29. Gao L, Bai L, Nan Qz. Activation of Rho GTPase Cdc42 promotes adhesion and invasion in co-lorectal cancer cells. Med Sci Monit Basic Res 2013; 19: 201-207.
30. Chen QY, Jiao DM, Yao QH. Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell li-nes. Int J Oncol 2012; 40: 1561-1568.
31. Jung ID, Lee J, Yun SY. Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells. FEBS Lett 2002; 532: 351-6.