microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN

Oncology Letters

Volumn 4, Issue 5, 2012, Pages 1125-1129

  Mao, Jian Hua ^a   Zhou, Rong Ping ^a   Peng, Ai Fen ^b   Liu, Zhi Li ^a   Huang, Shan Hu ^a   Long, Xin Hua ^a   Shu, Yong ^a  

^a NANCHANG UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Fatty acid synthase; Metastasis; MiR 195; Osteosarcoma

Indexed keywords

FATTY ACID SYNTHASE; MICRORNA; MICRORNA 195; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

EID: 84866078028     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.863     Document Type: Article

References (41)

1. Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 115: 1531-1543, 2009.
2. Lewis VO: What's new in musculoskeletal oncology. J Bone Joint Surg Am 91: 1546-1556, 2009.
3. Meyers PA, Schwartz CL, Krailo M, et al: Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol 23: 2004-2011, 2005.
4. Cho Y, Jung GH, Chung SH, Kim JY, Choi Y and Kim JD: Long-term survivals of stage IIb osteosarcoma: a 20-year experience in a single institution. Clin Orthop Surg 3: 48-54, 2011.
5. Tsuchiya H, Tomita K, Mori Y, et al: Caffeine-assisted chemotherapy and minimized tumor excision for nonmetastatic osteosarcoma. Anticancer Res 18: 657-666, 1998.
6. Bolling T, Schuller P, Distelmaier B, et al: Perioperative high-dose rate brachytherapy using a bendy applicator (flab): treatment results of 74 patients. Anticancer Res 28: 3885-3890, 2008.
7. Marina N, Gebhardt M, Teot L and Gorlick R: Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9: 422-441, 2004.
8. Wada T, Isu K, Takeda N, Usui M, Ishii S and Yamawaki S: A preliminary report of neoadjuvant chemotherapy NSH-7 study in osteosarcoma: preoperative salvage chemotherapy based on clinical tumor response and the use of granulocyte colony-stimulating factor. Oncology 53: 221-227, 1996.
9. Yeh CS, Wang JY, Cheng TL, Juan CH, Wu CH and Lin SR: Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. Cancer Lett 233: 297-308, 2006.
10. Hess D and Igal RA: Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells. Exp Biol Med (Maywood) 236: 707-713, 2011.
11. Alo PL, Amini M, Piro F, et al: Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. Anticancer Res 27: 2523-2527, 2007.
12. Walter K, Hong SM, Nyhan S, et al: Serum fatty acid synthase as a marker of pancreatic neoplasia. Cancer Epidemiol Biomarkers Prev 18: 2380-2385, 2009.
13. Okawa Y, Hideshima T, Ikeda H, et al: Fatty acid synthase is a novel therapeutic target in multiple myeloma. Br J Haematol 141: 659-671, 2008.
14. Migita T, Ruiz S, Fornari A, et al: Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst 101: 519-532, 2009.
15. Orita H, Coulter J, Tully E, Kuhajda FP and Gabrielson E: Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. Clin Cancer Res 14: 2458-2464, 2008.
16. Coleman DT, Bigelow R and Cardelli JA: Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation. Mol Cancer Ther 8: 214-224, 2009.
17. Saati GE and Archer MC: Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells. Nutr Cancer 63: 790-794, 2011.
18. Notarnicola M, Pisanti S, Tutino V, et al: Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr 6: 63-69, 2011.
19. Notarnicola M, Messa C, Refolo MG, Tutino V, Miccolis A and Caruso MG: Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line. Lipids Health Dis 10: 10, 2011.
20. Zecchin KG, Rossato FA, Raposo HF, et al: Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis. Lab Invest 91: 232-240, 2011.
21. Carvalho MA, Zecchin KG, Seguin F, et al: Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer 123: 2557-2565, 2008.
22. Murata S, Yanagisawa K, Fukunaga K, et al: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci 101: 1861-1865, 2010.
23. Kim VN, Han J and Siomi MC: Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 10: 126-139, 2009.
24. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233, 2009.
25. Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20: 515-524, 2006.
26. Calin GA, Sevignani C, Dumitru CD, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101: 2999-3004, 2004.
27. Wang X, Wang J, Ma H, Zhang J and Zhou X: Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer. Med Oncol 2011.
28. Bai X, Ma D, Liu A, et al: Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318: 977-980, 2007.
29. Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP and Zhuang SM: MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 50: 113-121, 2009.
30. Soon PS, Tacon LJ, Gill AJ, et al: miR-195 and miR-483-5p identified as predictors of poor prognosis in adrenocortical cancer. Clin Cancer Res 15: 7684-7692, 2009.
31. Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 14: 2588-2592, 2008.
32. Liu L, Chen L, Xu Y, Li R and Du X: microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun 400: 236-240, 2010.
33. Li D, Zhao Y, Liu C, et al: Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res 17: 1722-1730, 2011.
34. Brenner B, Hoshen MB, Purim O, et al: MicroRNAs as a potential prognostic factor in gastric cancer. World J Gastroenterol 17: 3976-3985, 2011.
35. Heneghan HM, Miller N, Kelly R, Newell J and Kerin MJ: Systemic miR-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease. Oncologist 15: 673-682, 2010.
36. Heneghan HM, Miller N, Lowery AJ, Sweeney KJ, Newell J and Kerin MJ: Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg 251: 499-505, 2010.
37. Hannafon BN, Sebastiani P, de las Morenas A, Lu J and Rosenberg CL: Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res 13: R24, 2011.
38. Zhang H, Su SB, Zhou QM and Lu YY: Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells. Ai Zheng 28: 493-499, 2009.
39. Zanette DL, Rivadavia F, Molfetta GA, et al: miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res 40: 1435-1440, 2007.
40. Wu WY, Xue XY, Chen ZJ, et al: Potentially predictive microRNAs of gastric cancer with metastasis to lymph node. World J Gastroenterol 17: 3645-3651, 2011.
41. Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N: Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58-63, 2008.