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Volumn 9, Issue 15, 2014, Pages 2323-2337

Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma

Author keywords

diethyl nitrosamine; hepatocarcinogenesis; MMP 13; nanocapsulated quercetin; proinflammatory cytokines; reactive oxygen species

Indexed keywords

COLLAGENASE 3; DIETHYLNITROSAMINE; INTERLEUKIN 6; NANOCAPSULE; QUERCETIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84912061561     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.14.11     Document Type: Article
Times cited : (28)

References (51)
  • 1
    • 84863303647 scopus 로고    scopus 로고
    • Phase 1 trial of glypican-3-derived peptide vaccine for advanced hepatocellular carcinoma: Immunological evidence and potential for improving overall survival
    • Sawada Y, Yoshikawa T, Nobuoka D et al. Phase 1 trial of glypican-3-derived peptide vaccine for advanced hepatocellular carcinoma: immunological evidence and potential for improving overall survival. Clin. Cancer Res. 18, 3686-3696 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3686-3696
    • Sawada, Y.1    Yoshikawa, T.2    Nobuoka, D.3
  • 2
    • 0030041188 scopus 로고    scopus 로고
    • Emerging issues in mouse liver carcinogenesis
    • Ward JM, Shibata MA, Devor DE. Emerging issues in mouse liver carcinogenesis. Toxicol. Pathol. 24, 129-137 (1996).
    • (1996) Toxicol. Pathol. , vol.24 , pp. 129-137
    • Ward, J.M.1    Shibata, M.A.2    Devor, D.E.3
  • 3
    • 84857677413 scopus 로고    scopus 로고
    • Azidothymidine treatment of hepatocellular carcinoma in rats: An in vivo study of telomerase inhibition
    • Jeng KS, Sheen IS, Jeng WJ. Azidothymidine treatment of hepatocellular carcinoma in rats: an in vivo study of telomerase inhibition. Hepatogastroenterology 58, 2091-2096 (2011).
    • (2011) Hepatogastroenterology , vol.58 , pp. 2091-2096
    • Jeng, K.S.1    Sheen, I.S.2    Jeng, W.J.3
  • 4
    • 84855871427 scopus 로고    scopus 로고
    • Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model
    • Cuesta S, Kireev R, Garcia C et al. Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model. Mech. Ageing Dev. 132, 573-582 (2011).
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 573-582
    • Cuesta, S.1    Kireev, R.2    Garcia, C.3
  • 5
    • 84859635458 scopus 로고    scopus 로고
    • Emerging avenues linking inflammation and cancer
    • Kundu JK, Surh YJ. Emerging avenues linking inflammation and cancer. Free Radic. Biol. Med. 52, 2013-2037 (2012).
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 2013-2037
    • Kundu, J.K.1    Surh, Y.J.2
  • 7
    • 0026073289 scopus 로고
    • Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats
    • Aitio A, Aitio ML, Camus AM, Cardis E, Bartsch H. Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats. Jpn J. Cancer Res. 82, 146-156 (1991).
    • (1991) Jpn J. Cancer Res. , vol.82 , pp. 146-156
    • Aitio, A.1    Aitio, M.L.2    Camus, A.M.3    Cardis, E.4    Bartsch, H.5
  • 8
    • 80054775535 scopus 로고    scopus 로고
    • Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome
    • Ezquer M, Ezquer F, Ricca M, Allers C, Conget P. Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome. J. Hepatol. 55, 1112-1120 (2011).
    • (2011) J. Hepatol. , vol.55 , pp. 1112-1120
    • Ezquer, M.1    Ezquer, F.2    Ricca, M.3    Allers, C.4    Conget, P.5
  • 9
    • 83755207011 scopus 로고    scopus 로고
    • Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARd in inflammation-induced colon carcinogenesis
    • Monk JM, Kim W, Callaway E et al. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARd in inflammation-induced colon carcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G153-G167 (2012).
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302 , pp. G153-G167
    • Monk, J.M.1    Kim, W.2    Callaway, E.3
  • 10
    • 84856527774 scopus 로고    scopus 로고
    • Oncogenic b-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice
    • Anson M, Crain-Demoyelle AM, Baud V et al. Oncogenic b-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J. Clin. Invest. 122, 586-599 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 586-599
    • Anson, M.1    Crain-Demoyelle, A.M.2    Baud, V.3
  • 11
    • 84861782272 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma (review)
    • Leonardi GC, Candido S, Cervello M et al. The tumor microenvironment in hepatocellular carcinoma (review). Int. J. Oncol. 40, 1733-1747 (2012).
    • (2012) Int. J. Oncol. , vol.40 , pp. 1733-1747
    • Leonardi, G.C.1    Candido, S.2    Cervello, M.3
  • 12
    • 38649108511 scopus 로고    scopus 로고
    • Persistent and remodelling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappa B pathways
    • Mazzantini RP, de Conti A, Moreno FS. Persistent and remodelling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappa B pathways. J. Cell Biochem. 103, 538-546 (2008).
    • (2008) J. Cell Biochem. , vol.103 , pp. 538-546
    • Mazzantini, R.P.1    De Conti, A.2    Moreno, F.S.3
  • 13
    • 0027140406 scopus 로고
    • Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis
    • Stetler-Stevenson WG, Liotta LA, Kleiner DE Jr. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J. 7, 1434-1441 (1993).
    • (1993) FASEB J. , vol.7 , pp. 1434-1441
    • Stetler-Stevenson, W.G.1    Liotta, L.A.2    Kleiner, D.E.3
  • 14
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • Bergers G, Javaherian K, Lo K, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284, 808-812 (1999).
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.3    Folkman, J.4    Hanahan, D.5
  • 15
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens ML, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387-2392 (2002).
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, M.L.1    Fingleton, B.2    Matrisian, L.M.3
  • 17
    • 24644504005 scopus 로고    scopus 로고
    • Sugar coated liposomal flavonoid: A unique formulation in combating carbontetrachloride induced hepatic oxidative damage
    • Mandal AK, Das N. Sugar coated liposomal flavonoid: a unique formulation in combating carbontetrachloride induced hepatic oxidative damage. J. Drug Target. 13, 305-315 (2005).
    • (2005) J. Drug Target. , vol.13 , pp. 305-315
    • Mandal, A.K.1    Das, N.2
  • 18
    • 82555179203 scopus 로고    scopus 로고
    • Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats
    • Ghosh A, Ghosh D, Sarkar S, Mandal AK, Thakur Choudhury S, Das N. Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats. Eur. J. Cancer Prev. 21, 32-41 (2012).
    • (2012) Eur. J. Cancer Prev. , vol.21 , pp. 32-41
    • Ghosh, A.1    Ghosh, D.2    Sarkar, S.3    Mandal, A.K.4    Thakur Choudhury, S.5    Das, N.6
  • 20
    • 55849099605 scopus 로고    scopus 로고
    • Active targeting schemes for nanoparticle systems in cancer therapeutics
    • Byrne J, Betancourt T, Brannon-Peppas L. Active targeting schemes for nanoparticle systems in cancer therapeutics. Adv. Drug Deliv. Rev. 60,1615-1626 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1615-1626
    • Byrne, J.1    Betancourt, T.2    Brannon-Peppas, L.3
  • 21
    • 39449102666 scopus 로고    scopus 로고
    • Polymeric nanoparticles for cancer therapy
    • Parveen S, Sahoo S. Polymeric nanoparticles for cancer therapy. J. Drug Target.16,108-123 (2008).
    • (2008) J. Drug Target. , vol.16 , pp. 108-123
    • Parveen, S.1    Sahoo, S.2
  • 22
    • 4444379133 scopus 로고    scopus 로고
    • Nanoparticle and targeted systems for cancer therapy
    • Brannon-Peppas L, Blanchette J. Nanoparticle and targeted systems for cancer therapy. Adv. Drug Deliv. Rev. 56, 1649-1659 (2004).
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1649-1659
    • Brannon-Peppas, L.1    Blanchette, J.2
  • 23
    • 77952953213 scopus 로고    scopus 로고
    • Quercetin in vesicular delivery systems: Evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model
    • Ghosh D, Ghosh S, Sarkar S et al. Quercetin in vesicular delivery systems: evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model. Chem. Biol. Interact. 186, 61-71 (2010).
    • (2010) Chem. Biol. Interact. , vol.186 , pp. 61-71
    • Ghosh, D.1    Ghosh, S.2    Sarkar, S.3
  • 24
    • 0035126483 scopus 로고    scopus 로고
    • Effects of collagen IV and laminin on the reconstruction of human oral mucosa
    • Kim SW, Park KC, Kim, HJ et al. Effects of collagen IV and laminin on the reconstruction of human oral mucosa. J. Biomed. Mater Res. 58, 108-112 (2001).
    • (2001) J. Biomed. Mater Res. , vol.58 , pp. 108-112
    • Kim, S.W.1    Park, K.C.2    Kim, H.J.3
  • 25
    • 0037868155 scopus 로고    scopus 로고
    • Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase i and II: Implications in antileishmanial therapy
    • Chowdhury AR, Mandal S, Goswami A et al. Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy. Mol. Med. 9, 26-36 (2003).
    • (2003) Mol. Med. , vol.9 , pp. 26-36
    • Chowdhury, A.R.1    Mandal, S.2    Goswami, A.3
  • 26
    • 32244438967 scopus 로고    scopus 로고
    • Design of estradiol loaded PLGA nano particulate formulations: A potential oral delivery system for hormone therapy
    • Hariharan S, Bhardwaj V, Bala L, Sitterberg J, Bakowasky U, Kumar MNVR. Design of estradiol loaded PLGA nano particulate formulations: a potential oral delivery system for hormone therapy. Pharm. Res. 23, 184-195 (2006).
    • (2006) Pharm. Res. , vol.23 , pp. 184-195
    • Hariharan, S.1    Bhardwaj, V.2    Bala, L.3    Sitterberg, J.4    Bakowasky, U.5    Kumar, M.N.V.R.6
  • 27
    • 0018828701 scopus 로고
    • Proteins iodinated by the chloramines-T method appear to be degraded at an abnormally rapid rate after endocytosis
    • Opresko L, Wiley HS, Wallace RA. Proteins iodinated by the chloramines-T method appear to be degraded at an abnormally rapid rate after endocytosis. Proc. Natl Acad. Sci. USA 77, 1556-1560 (1980).
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 1556-1560
    • Opresko, L.1    Wiley, H.S.2    Wallace, R.A.3
  • 28
    • 75849162312 scopus 로고    scopus 로고
    • Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species
    • Changtam C, de Koning HP, Ibrahim H et al. Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur. J. Med. Chem. 45, 941-956 (2010).
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 941-956
    • Changtam, C.1    De Koning, H.P.2    Ibrahim, H.3
  • 29
    • 28844438726 scopus 로고    scopus 로고
    • In vitro and in vivo studies on vitamin e TPGS-emulsified poly (d, l-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation
    • Wina KY, Feng SS. In vitro and in vivo studies on vitamin E TPGS-emulsified poly (d, l-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation. Biomaterials 27, 2285-2291 (2006).
    • (2006) Biomaterials , vol.27 , pp. 2285-2291
    • Wina, K.Y.1    Feng, S.S.2
  • 30
    • 33344464320 scopus 로고    scopus 로고
    • Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain
    • Sarkar S, Das N. Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain. Mech. Age. Develop. 127, 391-397 (2006).
    • (2006) Mech. Age. Develop. , vol.127 , pp. 391-397
    • Sarkar, S.1    Das, N.2
  • 32
    • 0033800602 scopus 로고    scopus 로고
    • Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure and its relation to dietary protein deficiency
    • Maiti S, Chatterjee AK. Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure and its relation to dietary protein deficiency. Environ. Tox. Pharm. 8, 227-235 (2000).
    • (2000) Environ. Tox. Pharm. , vol.8 , pp. 227-235
    • Maiti, S.1    Chatterjee, A.K.2
  • 33
    • 0036637715 scopus 로고    scopus 로고
    • Targeting of liposomal flavonoid to liver in combating hepatocellular oxidative damage
    • Mandal AK, Sinha J, Mandal S, Mukhopadhyay S, Das N. Targeting of liposomal flavonoid to liver in combating hepatocellular oxidative damage. Drug Deliv. 9, 181-185 (2002).
    • (2002) Drug Deliv. , vol.9 , pp. 181-185
    • Mandal, A.K.1    Sinha, J.2    Mandal, S.3    Mukhopadhyay, S.4    Das, N.5
  • 34
    • 0025102226 scopus 로고
    • Determination of carbonyl content in oxidatively modified proteins
    • Levine RL, Garland D, Oliver CN et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186, 464-478 (1990).
    • (1990) Methods Enzymol. , vol.186 , pp. 464-478
    • Levine, R.L.1    Garland, D.2    Oliver, C.N.3
  • 37
    • 70350436076 scopus 로고    scopus 로고
    • Stealth nanoparticles coated with heparin as peptide or protein carriers
    • Socha M, Bartecki P, Passirani C et al. Stealth nanoparticles coated with heparin as peptide or protein carriers. J. Drug Target. 17, 575-585 (2009).
    • (2009) J. Drug Target. , vol.17 , pp. 575-585
    • Socha, M.1    Bartecki, P.2    Passirani, C.3
  • 38
    • 61349139614 scopus 로고    scopus 로고
    • Drug delivery and nanoparticles: Applications and hazards
    • De Jong WH, Borm PJA. Drug delivery and nanoparticles: applications and hazards. Int. J. Nanomed. 3, 133-149 (2008).
    • (2008) Int. J. Nanomed. , vol.3 , pp. 133-149
    • De Jong, W.H.1    Borm, P.J.A.2
  • 39
    • 78650797814 scopus 로고    scopus 로고
    • Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in the Gambia
    • Umoh NJ, Lesi OA, Mendy M et al. Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia. Liver Int. 31, 215-221 (2011).
    • (2011) Liver Int. , vol.31 , pp. 215-221
    • Umoh, N.J.1    Lesi, O.A.2    Mendy, M.3
  • 40
    • 0033839715 scopus 로고    scopus 로고
    • Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid
    • Bishayee A, Sarkar A, Chatterjee M. Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and Phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid. Nutr. Cancer 37, 89-98 (2000)
    • (2000) Nutr. Cancer , vol.37 , pp. 89-98
    • Bishayee, A.1    Sarkar, A.2    Chatterjee, M.3
  • 41
    • 33845345975 scopus 로고    scopus 로고
    • Oxidative stress induces premature scnescence by stimulating caveolin 1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
    • Dasari A, Bartholonew JN, Volonte D, Galbiati F. Oxidative stress induces premature scnescence by stimulating caveolin 1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res. 66, 10805-10814 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 10805-10814
    • Dasari, A.1    Bartholonew, J.N.2    Volonte, D.3    Galbiati, F.4
  • 42
    • 33744795150 scopus 로고    scopus 로고
    • Liposomal quercetin efficiently suppresses growth of solid tumors in murine models
    • Zhi-Ping Y, Li-Juan C, Lin-Yu F et al. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin. Cancer Res. 12, 3193-3199 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3193-3199
    • Zhi-Ping, Y.1    Li-Juan, C.2    Lin-Yu, F.3
  • 43
    • 82855176141 scopus 로고    scopus 로고
    • Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (13C) in rats
    • Shimamoto K, Hayashi H, Taniai E et al. Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (13C) in rats. J. Toxicol. Sci. 36, 775-786 (2011).
    • (2011) J. Toxicol. Sci. , vol.36 , pp. 775-786
    • Shimamoto, K.1    Hayashi, H.2    Taniai, E.3
  • 44
    • 0347660879 scopus 로고    scopus 로고
    • Promyelocytic HL60 cells express NADPH oxidase and are excellent targets in a rapid spectrophotometric microplate assay for extracellular superoxide
    • Teufelhofer O, Weiss RM, Parzefall W et al. Promyelocytic HL60 cells express NADPH oxidase and are excellent targets in a rapid spectrophotometric microplate assay for extracellular superoxide. Toxicol. Sci. 76, 376-383 (2003).
    • (2003) Toxicol. Sci. , vol.76 , pp. 376-383
    • Teufelhofer, O.1    Weiss, R.M.2    Parzefall, W.3
  • 45
    • 17044429015 scopus 로고    scopus 로고
    • Oxidative stress on mitochondrial antioxidant defense system in the aging process: Role of DL -alpha-lipoic acid and L-carnitine
    • Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C. Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL -alpha-lipoic acid and L-carnitine. Clin. Chem. Acta. 355, 173-180 (2005).
    • (2005) Clin. Chem. Acta. , vol.355 , pp. 173-180
    • Savitha, S.1    Tamilselvan, J.2    Anusuyadevi, M.3    Panneerselvam, C.4
  • 46
    • 33745265207 scopus 로고    scopus 로고
    • Reactive oxygen species: Role in the development of cancer and various chronic conditions
    • Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinog. 5, 14 (2006).
    • (2006) J. Carcinog. , vol.5 , pp. 14
    • Waris, G.1    Ahsan, H.2
  • 47
    • 83555173193 scopus 로고    scopus 로고
    • Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
    • Jayakumar S, Madankumar A, Asokkumar S et al. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Mol. Cell Biochem. 360, 51-60 (2012).
    • (2012) Mol. Cell Biochem. , vol.360 , pp. 51-60
    • Jayakumar, S.1    Madankumar, A.2    Asokkumar, S.3
  • 48
    • 84856948223 scopus 로고    scopus 로고
    • Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease
    • Gao B. Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease. J. Gastroenterol. Hepatol. 27, 89-93 (2012).
    • (2012) J. Gastroenterol. Hepatol. , vol.27 , pp. 89-93
    • Gao, B.1
  • 49
    • 84860533842 scopus 로고    scopus 로고
    • IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway
    • Liu M, Liu H, Wang X, Chen P, Chen H. IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway. Int. J. Mol. Med. 29, 1106-1112 (2012).
    • (2012) Int. J. Mol. Med. , vol.29 , pp. 1106-1112
    • Liu, M.1    Liu, H.2    Wang, X.3    Chen, P.4    Chen, H.5
  • 50
    • 79956225093 scopus 로고    scopus 로고
    • Inhibitory effect of phytoglycoprotein (24kDa) on hepatocarcinogenesis in N-nitrosodiethylamine-treated ICR mice
    • Lee J, Lim KT. Inhibitory effect of phytoglycoprotein (24kDa) on hepatocarcinogenesis in N-nitrosodiethylamine-treated ICR mice. J. Pharm. Pharmacol. 63, 840-848 (2011).
    • (2011) J. Pharm. Pharmacol. , vol.63 , pp. 840-848
    • Lee, J.1    Lim, K.T.2
  • 51
    • 84855328537 scopus 로고    scopus 로고
    • Signaling pathways governing tumor angiogenesis
    • Sakurai T, Kudo M. Signaling pathways governing tumor angiogenesis. Oncology 81, 24-29 (2011).
    • (2011) Oncology , vol.81 , pp. 24-29
    • Sakurai, T.1    Kudo, M.2


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