Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway

Biochimie

Volumn 108, Issue , 2015, Pages 85-93

  Wang, Lin ^a   Zhao, Xiong ^a   Wei, Bo Yuan ^a   Liu, Yi ^b   Ma, Xiang Yu ^a   Wang, Jian ^a   Cao, Peng Chong ^a   Zhang, Yang ^a   Yan, Ya Bo ^a   Lei, Wei ^a   Feng, Ya Fei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes; Insulin; PI3K Akt; Reactive oxygen species; Titanium implant

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CASPASE 3; CASPASE 7; INSULIN; OSTEOCALCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TEMPOL; TITANIUM; TRANSCRIPTION FACTOR RUNX2; ALKALINE PHOSPHATASE; ANTIOXIDANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE IMPLANT; BONE REGENERATION; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DIABETIC PATIENT; ENZYME ACTIVITY; HUMAN; INSULIN TREATMENT; LIPID PEROXIDATION; METABOLIC REGULATION; NONHUMAN; OSTEOBLAST; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; TITANIUM IMPLANT; ANIMAL; CYTOLOGY; DIABETES MELLITUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROSTHESES AND ORTHOSES; RABBIT; SIGNAL TRANSDUCTION;

ALKALINE PHOSPHATASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL ADHESION; CELL PROLIFERATION; DIABETES MELLITUS; GENE EXPRESSION REGULATION; INSULIN; OSTEOBLASTS; OSTEOGENESIS; PHOSPHATIDYLINOSITOL 3-KINASE; PROSTHESES AND IMPLANTS; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TITANIUM;

EID: 84912060366     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.10.004     Document Type: Article

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