Effects of locally administered insulin on bone formation in non-diabetic rats

Journal of Biomedical Materials Research - Part A

Volumn 101 A, Issue 1, 2013, Pages 132-137

  Malekzadeh, B ^a,b,c   Tengvall, P ^a   Ohrnell, L O ^b   Wennerberg, A ^d   Westerlund, A ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d MALMÖ UNIVERSITY   (Sweden)

Author keywords

Bone; Drug delivery; Implant; Insulin; Slow release

Indexed keywords

BONE DEFECT; BONE FORMATION; BONE HEALING; BONE TISSUE; HISTOMORPHOMETRY; IMPLANT SURFACE; INSULIN IMMOBILIZATION; SLOW RELEASE; THERAPEUTIC STRATEGY; TITANIUM IMPLANT SURFACE;

DRUG DELIVERY; IMPLANTS (SURGICAL); INSULIN; RATS; SURFACE TOPOGRAPHY; TISSUE; TITANIUM;

BONE;

HUMAN INSULIN; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE IMPLANT; BONE SCREW; CONNECTIVE TISSUE; CONTROLLED STUDY; DRUG EFFECT; IMMOBILIZATION; INTERFEROMETRY; MALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; RAT; REPEAT PROCEDURE; SURFACE PROPERTY; TIBIA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; IMAGING, THREE-DIMENSIONAL; IMPLANTS, EXPERIMENTAL; INSULIN; MALE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TITANIUM;

EID: 84872678200     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34313     Document Type: Article

References (41)

1. Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem 2010;285:25103-108.
2. Pun KK, Lau P, Ho PW. The characterization, regulation, and function of insulin receptors on osteoblast-like clonal osteosarcoma cell line. J Bone Miner Res 1989;4:853-862.
3. Kream BE, Smith MD, Canalis E, Raisz LG. Characterization of the effect of insulin on collagen synthesis in fetal rat bone. Endocrinology 1985;116:296-302.
4. Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 2005;289:E735-E745.
5. Kemink SA, Hermus AR, Swinkels LM, Lutterman JA, Smals AG. Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology. J Endocrinol Invest 2000;23: 295-303.
6. Bouillon R. Diabetic bone disease. Calcif Tissue Int 1991;49: 155-160.
7. Iacopino AM. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001;6:125-137.
8. DM Thomas KWN, James D Best. Inuslin and bone: A clinical and scientific review. Endocrinol Metab 1997;4:5-17.
9. Fiorellini JP, Nevins ML. Dental implant considerations in the diabetic patient. Periodontol 2000;23:73-77.
10. Mishima N, Sahara N, Shirakawa M, Ozawa H. Effect of streptozotocin- induced diabetes mellitus on alveolar bone deposition in the rat. Arch Oral Biol 2002;47:843-849.
11. Giglio MJ, Giannunzio G, Olmedo D, Guglielmotti MB. Histomorphometric study of bone healing around laminar implants in experimental diabetes. Implant Dent 2000;9:143-149.
12. Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronsson J, Lumpkin CK Jr. Bone formation is impaired in a model of type 1 diabetes. Diabetes 2005;54:2875-2881.
13. Gandhi A, Beam HA, O'Connor JP, Parsons JR, Lin SS. The effects of local insulin delivery on diabetic fracture healing. Bone 2005;37:482-490.
14. Kwon PT, Rahman SS, Kim DM, Kopman JA, Karimbux NY, Fiorellini JP. Maintenance of osseointegration utilizing insulin therapy in a diabetic rat model. J Periodontol 2005;76:621-626.
15. Glajchen N, Epstein S, Ismail F, Thomas S, Fallon M, Chakrabarti S. Bone mineral metabolism in experimental diabetes mellitus: osteocalcin as a measure of bone remodeling. Endocrinology 1988;123:290-295.
16. Dedania J, Borzio R, Paglia D, Breitbart EA, Mitchell A, Vaidya S, Wey A, Mehta S, Benevenia J, O'Connor JP, Lin SS. Role of local insulin augmentation upon allograft incorporation in a rat femoral defect model. J Orthop Res 2011;29:92-99.
17. Thomas DM, Hards DK, Rogers SD, Ng KW, Best JD. Insulin receptor expression in bone. J Bone Miner Res 1996;11:1312-1320.
18. Thomas DM, Udagawa N, Hards DK, Quinn JM, Moseley JM, Findlay DM, Best JD. Insulin receptor expression in primary and cultured osteoclast-like cells. Bone 1998;23:181-186.
19. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Bruning JC, Clemens TL. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 2010;142:309-319.
20. Yang J, Zhang X, Wang W, Liu J. Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. Cell Biochem Funct 2010;28:334-341.
21. Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010;142:296-308.
22. Clemens TL, Karsenty G. The osteoblast: An insulin target cell controlling glucose homeostasis. J Bone Miner Res 2010:677-680.
23. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauxais-Jarvis F, Ducy P, Kersenti G. Endocrine regulation of energy metabolism by the skeleton. Cell 2007;130:456-469.
24. Sul YT, Johansson CB, Albrektsson T. Oxidized titanium screws coated with calcium ions and their performance in rabbit bone. Int J Oral Maxillofac Implants 2002;17:625-634.
25. Tengvall P, Skoglund B, Askendal A, Aspenberg P. Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats. Biomaterials 2004;25:2133-2138.
26. Wennerberg A, Albrektsson T. Suggested guidelines for the topographic evaluation of implant surfaces. Int J Oral Maxillofac Implants 2000;15:331-344.
27. Donath K. Die Trenn-Dunnschliff-Tecknik zur Herstellung histologischer Präparate von nicht schneidbaren Geweben und Materialen. Der Präparator 1988;34:197-206.
28. Siqueira JT, Cavalher-Machado SC, Arana-Chavez VE, Sannomiya P. Bone formation around titanium implants in the rat tibia: Role of insulin. Implant Dent 2003;12:242-251.
29. Frojd V, Wennerberg A, Franke Stenport V. Importance of Ca(2+) modifications for osseointegration of smooth and moderately rough anodized titanium implants - A removal torque and histological evaluation in rabbit. Clin Implant Dent Relat Res 2010 [Epub ahead of print].
30. Wennerberg A. On Surface Roughness and Implant Incorporation. Göteborg, Sweden: University of Gothenburg; 1996.
31. Herberts P, Malchau H. Many years of registration have improved the quality of hip arthroplasty. Lakartidningen 1999;96:2469-2473, 2475-2476.
32. Schouten C, Meijer GJ, van den Beucken JJ, Spauwen PH, Jansen JA. Effects of implant geometry, surface properties, and TGFbeta1 on peri-implant bone response: An experimental study in goats. Clin Oral Implants Res 2009;20:421-429.
33. Stadlinger B, Pilling E, Huhle M, Mai R, Bierbaum S, Scharnweber D, Kuhlisch E, Loukota R, Eckelt U. Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: An animal study. Int J Oral Maxillofac Surg 2008;37:54-59.
34. Wermelin K, Aspenberg P, Linderback P, Tengvall P. Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks. J Biomed Mater Res A 2008;86(1): 220-227.
35. Vehof JW, Haus MT, de Ruijter AE, Spauwen PH, Jansen JA. Bone formation in transforming growth factor beta-I-loaded titanium fiber mesh implants. Clin Oral Implants Res 2002;13:94-102.
36. Vehof JW, Takita H, Kuboki Y, Spauwen PH, Jansen JA. Histological characterization of the early stages of bone morphogenetic protein-induced osteogenesis. J Biomed Mater Res 2002;61:440-449.
37. Kajiwara H, Yamaza T, Yoshinari M, Goto T, Iyama S, Atsuta I, Kido MA, Tanaka T. The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. Biomaterials 2005;26:581-587.
38. Yoshinari M, Oda Y, Inoue T, Matsuzaka K, Shimono M. Bone response to calcium phosphate-coated and bisphosphonate- immobilized titanium implants. Biomaterials 2002;23:2879-2885.
39. Goransson A, Jansson E, Tengvall P, Wennerberg A. Bone formation after 4 weeks around blood-plasma-modified titanium implants with varying surface topographies: An in vivo study. Biomaterials 2003;24:197-205.
40. Goransson A, Gretzer C, Johansson A, Sul YT, Wennerberg A. Inflammatory response to a titanium surface with potential bioactive properties: An in vitro study. Clin Implant Dent Relat Res 2006;8:210-217.
41. Tengvall P, Jansson E, Askendal A, Thomsen P, Gretzer C. Preparation of multilayer plasma protein films by EDS/NHS coupling chemistry on silicon. Colloids Surf B Biointerfaces 2003;28: 261-272.