Implant healing in experimental animal models of diabetes

Journal of Diabetes Science and Technology

Volumn 5, Issue 3, 2011, Pages 605-618

  Le, Nga N ^a   Rose, Michael B ^a   Levinson, Howard ^a   Klitzman, Bruce ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Biomedical implants; Foreign body response; Sensors; Wound healing

Indexed keywords

ALLOXAN; EPIDERMAL GROWTH FACTOR; GELATINASE A; INSULIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; POLYSTYRENE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; SIMVASTATIN; STREPTOZOCIN; TITANIUM; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; SIGNAL PEPTIDE;

ADAPTIVE IMMUNITY; ALLOXAN DIABETES MELLITUS; CATHETER INFECTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CHONDROGENESIS; CONFERENCE PAPER; DEVICE INFECTION; DIABETIC COMA; DIABETIC KETOACIDOSIS; DIABETIC PATIENT; FOREIGN BODY; HOSPITAL INFECTION; HUMAN; HUMORAL IMMUNITY; HYPERGLYCEMIA; IMMUNE DEFICIENCY; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; INDWELLING CATHETER; INFECTION SENSITIVITY; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; JOINT PROSTHESIS; KERATINOCYTE; MEDICAL DEVICE COMPLICATION; MOLECULAR PATHOLOGY; MYOFIBROBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORTHOPEDIC FIXATION DEVICE; PANCREAS ISLET BETA CELL; PATHOGENESIS; PENIS PROSTHESIS; PROSTHESIS INFECTION; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; SURGICAL MESH; URINARY CATHETER; WOUND HEALING; WOUND INFECTION; ANIMAL; BLOOD GLUCOSE MONITORING; CANDIDIASIS; CROSS INFECTION; DEFIBRILLATOR; DIABETES MELLITUS; FIBROSIS; GENETIC PROCEDURES; GLUCOSE BLOOD LEVEL; METABOLISM; METHODOLOGY; ORTHOPEDICS; PATHOLOGY; PROSTHESES AND ORTHOSES; PROSTHESIS FAILURE; REVIEW;

ANIMALS; BIOSENSING TECHNIQUES; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; CANDIDIASIS; CROSS INFECTION; CYTOKINES; DEFIBRILLATORS, IMPLANTABLE; DIABETES COMPLICATIONS; FIBROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ORTHOPEDICS; PROSTHESES AND IMPLANTS; PROSTHESIS FAILURE; WOUND HEALING;

EID: 84858763242     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681100500315     Document Type: Conference Paper

References (65)

1. Boyle J, Honeycutt A, Narayan KM, Hoerger TJ, Geiss LS, Chen H, Thompson TJ. Projection of diabetes burden through 2050. Diabetes Care. 2001;24(11):1936-40.
2. Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med. 2004;350(14):1422-9. (Pubitemid 38419996)
3. MediThai. Global trend in the dental industry. Available from: http://www.medithai.net/en/Implants/prices-of-dental- implants.
4. Medtronic. Medtronic announces sales milestone of one million continuous glucose monitoring sensors worldwide; 2008 Mar 24. Available from: http://wwwp.medtronic.com/Newsroom/NewsReleaseDetails.do?itemId= 1206362990112&lang=en- US.
5. Gollwitzer H, Ibrahim K, Meyer H, Mittelmeier W, Busch R, Stemberger A. Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology. J Antimicrob Chemother. 2003;51(3):585-91. (Pubitemid 36336150)
6. Whitehouse JD, Friedman ND, Kirkland KB, Richardson WJ, Sexton DJ. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol. 2002;23(4):183-9. (Pubitemid 34297271)
7. Darouiche RO. Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;33(9):1567-72. (Pubitemid 34246153)
8. Oh BK, Robbins ME, Nablo BJ, Schoenfisch. Miniaturized glucose biosensor modified with a nitric oxide-releasing xerogel microarray. Biosens Bioelectron. 2005;21(5):749-57. (Pubitemid 41476308)
9. Fahey TJ, Sadaty A, Jones WG 2nd, Barber A, Smoller B, Shires GT. Diabetes impairs the late inflammatory response to wound healing. J Surg Res. 1991;50(4):308-13.
10. Calvet HM, Yoshikawa TT. Infections in diabetes. Infect Dis Clin North Am. 2001;15(2):407-21. (Pubitemid 32606907)
11. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117(5):1219-22. (Pubitemid 46718408)
12. Witte MB, Kiyama T, Barbul A. Nitric oxide enhances experimental wound healing in diabetes. Br J Surg. 2002;89(12):1594-601. (Pubitemid 35404331)
13. Bertoni AG, Saydah S, Brancati FL. Diabetes and the risk of infection-related mortality in the U.S. Diabetes Care. 2001;24(6):1044-9. (Pubitemid 33716374)
14. Fang A, Hu S, Endres N, Bradford D. Risk factors for infection after spinal surgery. Spine (Phila Pa 1976). 2005;30(12):1460-5.
15. Liao J, Chen W, Chen L, Niu C. Postoperative wound infection rates after posterior instrumented spinal surgery in diabetic patients. Chang Gung Med J. 2006;29(5):480-5. (Pubitemid 44948140)
16. Chen S, Anderson M, Cheng W, Wongworawat M. Diabetes associated with increased surgical site infections in spinal arthrodesis. Clin Orthop Relat Res. 2009;467(7):1670-3.
17. Marchant M, Viens N, Cook C, Vail T, Bolognesi M. The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty. J Bone Joint Surg Am. 2009;91(7):1621-9.
18. Geerlings SE, Hoepelman A. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol. 1999;26 (3-4):259-65.
19. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol. 1990;136(6):1235-46. (Pubitemid 20210322)
20. Bitto A, Minutoli L, Altavilla D, Polito F, Fiumara T, Marini H, Galeano M, Calò M, Lo Cascio P, Bonaiuto M, Migliorato A, Caputi AP, Squadrito F. Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes. Pharmacological Res. 2008;57(2):159-69.
21. Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal epithelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen. 2006;14(5):558-65. (Pubitemid 44470072)
22. Goren I, Müller E, Pfeilschifter J, Frank S. Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha. Am J Pathol. 2006;168(3):765-77. (Pubitemid 43327729)
23. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736-43. (Pubitemid 41587454)
24. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, Bunting S, Steinmetz HG, Gurtner GC. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol. 2004;164(6):1935-47. (Pubitemid 38669343)
25. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol. 2007;170(4):1178-91. (Pubitemid 47339326)
26. Gibran NS, Jang YC, Isik FF, Greenhalgh DG, Muffley LA, Underwood RA, Usui ML, Larsen J, Smith DG, Bunnett N, Ansel JC, Olerud JE. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J Surg Res. 2002;108(1):122-8. (Pubitemid 35373824)
27. Lobmann R, Ambrosch A, Schultz G, Waldmann K, Schiweck S, Lehnert H. Expression of matrix-metalloproeinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia. 2002;45(7):1011-6. (Pubitemid 34762196)
28. Ochoa O, Torres FM, Shireman PK. Chemokines and diabetic wound healing. Vascular. 2007;15(6):350-5. (Pubitemid 350305401)
29. Rafehi H, El-Osta A, Karagiannis TC. Genetic and epigenetic events in diabetic wound healing. Int Wound J. 2011;8(1):12-21.
30. Darby IA, Bisucci T, Hewitson TD, MacLellan DG. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int J Biochem Cell Biol. 1997;29(1):191-200. (Pubitemid 27096432)
31. Thomson SE, McLennan SV, Hennessy A, Boughton P, Bonner J, Zoellner H, Yue DK, Twigg SM. A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia. 2010;53(3):572-83.
32. Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type 1 and type II diabetic wounds. Wound Repair Regen. 2004;12(5):497-504. (Pubitemid 39314331)
33. Lauer G, Sollberg S, Cole M, Flamme I, Stürzebecher J, Mann K, Krieg T, Eming SA. Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol. 2000;115(1):12-8. (Pubitemid 30470185)
34. Nablo BJ, Schoenfisch MH. Antibacterial properties of nitric-oxide releasing sol-gels. J Biomed Mater Res A. 2003;67(4):1276-83. (Pubitemid 37522741)
35. Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am. 1997;77(3):509-28. (Pubitemid 27256032)
36. Marhoffer W, Stein M, Maeser E, Federlin K. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. Diabetes Care. 1992;15(2):256-60.
37. Sima AA, O'Neill SJ, Naimark D, Yagihashi S, Klass D. Bacterial phagocytosis and intracellular killing by alveolar macrophages in BB rats. Diabetes. 1988;37(5):544-9.
38. Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus. Free Radic Biol Med. 1998;25(7):757-65. (Pubitemid 28512527)
39. Bitar MS, Labbad ZN. Transforming growth factor-beta and insulinlike growth factor-1 in relation to diabetes-induced impairment of wound healing. J Surg Res. 1996;61(1):113-9. (Pubitemid 26066038)
40. Beer HD, Longaker MT, Werner S. Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol. 1997;109(2):132-8. (Pubitemid 27337325)
41. Bitar MS. Insulin-like growth factor-1 reverses diabetes-induced wound healing impairment in rats. Horm Metab Res. 1997;29(8):383-6. (Pubitemid 27362062)
42. Hehenberger K, Heilborn JD, Brismar K, Hansson A. Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of L-lactate. Wound Repair Regen. 1998;6(2):135-41. (Pubitemid 128659189)
43. Goldstein S, Moreman EJ, Soeldner JS, Gleason RE, Barnett DM. Diabetes mellitus and genetic prediabetes. Decreased replicative capacity of culture skin fibroblasts. J Clin Invest. 1979;63(3):358-70. (Pubitemid 9130198)
44. Falanga V. The chronic wound: impaired healing and solutions in the context of wound bed preparation. Blood Cells Mol Dis. 2004;32(1):88-94. (Pubitemid 38147702)
45. Mellado-Valero A, Ferrer García JC, Herrera Ballester A, Labaig Rueda C. Effects of diabetes on the osseointegration of dental implants. Med Oral Patol Oral Cir Bucal. 2007;12(1):E38-43.
46. Follak N, Kloting I, Merk H. Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats. Diabetes Metab Res Rev. 2005;21(3):288-96. (Pubitemid 40716162)
47. Botolin S, Faugere M, Malluche H, Orth M, Meyer R, McCabe LR. Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type 1 diabetic mice. Endocrinology. 2005;146(8):3622-31. (Pubitemid 41058134)
48. Kasahara T, Imai S, Kojima H, Katagi M, Kimura H, Chan L, Matsusue Y. Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone. 2010;47(3):617-25.
49. Ogasawara A, Nakajima A, Nakajima F, Goto K, Yamazaki M. Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat. Bone. 2008;43(5):832-9.
50. Gerritsen M, Lutterman J, Jansen J. The influence of impaired wound healing on the tissue reaction to percutaneous devices using titanium fiber mesh anchorage. J Biomed Mater Res. 2000;52(1):135-41. (Pubitemid 30490989)
51. Ledermann MM, Schiffman GA, Rodman HM. Pneumococcal immunization in adult diabetics. Diabetes. 1981;30(2):119-21. (Pubitemid 11018678)
52. Beam TR Jr, Crigler ED, Goldman JK, Schiffmann G. Antibody response to polyvalent pneumococcal polysaccharide vaccine in diabetes. JAMA. 1980;244(23):2641-4.
53. Li Volti S, Caruso-Nicoletti M, Biazzo F, Sciacca A, Mandarà G, Mancuso M, Mollica F. Hyporesponsiveness to intradermal administration of hepatitis B vaccine in insulin dependent diabetes mellitus. Arch Dis Child. 1998;78(1):54-7. (Pubitemid 28177584)
54. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte function in diabetic patients. Diabetic Med. 1997;14(1):29-34. (Pubitemid 27019919)
55. Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, Sannomiya P. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res. 2007;40(8):1037-44. (Pubitemid 47232857)
56. Park S, Rich J, Hanses F, Lee JC. Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphyloccus aureus. Infect Immun. 2009;77(3):1008-14.
57. Ma H, Liu G, Ding W, Wu Y, Cai L, Zhao Y. Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term. J Mol Med. 2008;86(4):391-400.
58. Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med. 2005;22(4):359-70. (Pubitemid 40516231)
59. Junod A, Lambert AE, Stauffacher W, Renold AE. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest. 1969;48(11):2129-39.
60. Lenzen S, Patten U. Alloxan: history and mechanism of action. Diabetologia. 1988;31(6):337-42.
61. Von Herrath M, Nepom GT. Animal models of human type 1 diabetes. Nat Immunol. 2009;10(2):129-32.
62. Janseen U, Phillips AO, Floege J. Rodent models of nephropathy associated with type II diabetes. J Nephrol. 1999;12(3):159-72. (Pubitemid 29370823)
63. Murakawa Y, Zhang W, Pierson CR, Brismar T, Ostenson CG, Efendic S, Sima AA. Impaired glucose tolerance and insulinopenia in the GK rat causes peripheral neuropathy. Diabetes Metab Res Rev. 2002;18(6):473-83. (Pubitemid 36041602)
64. Sone H, Kawakami Y, Okuda Y, Sekine Y, Honmura S, Matsuo K, Segawa T, Suzuki H, Yamashita K. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal preliferative changes. Diabetologia. 1997;40(6):726-30. (Pubitemid 27288120)
65. Olerud JE. Models for diabetic wound healing and healing into percutaneous devices. J Biomater Sci Polym Ed. 2008;19(8):1007-20. (Pubitemid 351957387)