Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: Removal torque and histomorphometric analysis in rats

Clinical Oral Implants Research

Volumn 24, Issue 7, 2013, Pages 831-837

  De Molon, Rafael Scaf ^a   Morais Camilo, Juliana Aparecida Najarro Dearo ^a   Verzola, Mario Henrique Arruda ^a   Faeda, Rafael Silveira ^a   Pepato, Maria Teresa ^a   Marcantonio, Elcio ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Bone density; Dental implant; Diabetes mellitus; Histology

Indexed keywords

ANTIDIABETIC AGENT; DENTAL MATERIAL; INSULIN; STREPTOZOCIN; TITANIUM;

ANIMAL; ARTICLE; BONE REGENERATION; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TIBIA; TOOTH IMPLANT; TORQUE; WISTAR RAT; WOUND HEALING;

ANIMALS; BLOOD GLUCOSE; DENTAL IMPLANTS; DENTAL MATERIALS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; MALE; OSSEOINTEGRATION; RANDOM ALLOCATION; RATS; RATS, WISTAR; STREPTOZOCIN; TIBIA; TITANIUM; TORQUE; WOUND HEALING;

EID: 84878698160     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2012.02467.x     Document Type: Article

References (39)

1. Adell, R., Eriksson, B., Lekholm, U., Brånemark, P.I. & Jemt, T. (1990) Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. International Journal of Oral & Maxillofacial Implants 5: 347-359.
2. Brånemark, P.I., Adell, R., Breine, U., Hansson, B.O., Lindstrom, J. & Ohlsson, A. (1969) Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scandinavian Journal of Plastic and Reconstructive Surgery 3: 81-100.
3. Carlsson, L.V., Alberktsson, T. & Berman, C. (1989) Bone response to plasma-cleaned titanium implants. International Journal of Oral & Maxillofacial Implants 4: 199-204.
4. Cordioli, G., Majzoub, Z., Piattelli, A. & Scarano, A. (2000) Removal torque and histomorphometric investigation of 4 different titanium surfaces: an experimental study in the rabbit tibia. International Journal of Oral & Maxillofacial Implants 15: 668-674.
5. Devlin, H., Garland, H. & Sloan, P. (1996) Healing of tooth extraction sockets in experimental diabetes mellitus. Journal of Oral & Maxillofacial Implants 54: 1087-1091.
6. Dixit, P.K. & Ekstrom, R.A. (1987) Retardation of bone fracture healing in experimental diabetes. Indian Journal of Medical Research 85: 426-435.
7. Donath, K. & Breuner, G. (1982) A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. Journal of Oral Pathology 4: 318-326.
8. Fiorellini, J.P., Nevins, M.L., Norkin, A., Weber, H.P. & Karimbux, N.Y. (1999) The effect of insulin therapy on osseointegration in a diabetic rat model. Clinical Oral Implants Research 10: 362-368.
9. Follak, N., Kloting, I., Wolf, E. & Merk, H. (2004) Histomorphometric evaluation of the influence of the diabetic metabolic state on bone defect healing depending on the defect size in spontaneously diabetic BB/OK rats. Bone 35: 144-152.
10. Giglio, M.J., Giannunzio, G., Olmedo, D. & Guglielmotti, M.B. (2000) Histomorphometric study of bone healing around laminar implants in experimental diabetes. Implant Dentistry 9: 143-149.
11. Goodman, W.G. & Hori, M.T. (1984) Diminished bone formation in experimental diabetes. Relationship to osteoid maturation and mineralization. Diabetes 33: 825-831.
12. Grandini, S.A., Brentegani, L.G., Novaes, A.B. & Migliorini, R.H. (1990) Protein synthesis in wound after tooth extraction in pancreatectomized diabetic rats. Brazilian Dental Journal 1: 25-30.
13. Holzhausen, M., Garcia, D.F., Pepato, M.T. & Marcantonio, E. Jr (2004) The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats. Journal of Periodontal Research 39: 188-193.
14. Hoskins, B. & Scott, J.M. (1984) Evidence for a direct action of insulin to increase renal reabsorption of calcium and for an irreversible defect in renal ability to conserve calcium due to prolonged absence of insulin. Diabetes 33: 991-994.
15. Kotsovilis, S., Karoussis, I.K. & Fourmousis, I. (2006) A comprehensive and critical review of dental implant placement in diabetic animals and patients. Clinical Oral Implants Research 17: 587-599.
16. Kwon, P.T., Rahman, S.S., Kim, D.M., Kopman, J.A., Karimbux, N.Y. & Fiorellini, J.P. (2005) Maintenance of osseointegration utilizing insulin therapy in a diabetic rat model. Journal of Periodontology 76: 621-626.
17. Lalla, E., Lamster, I.B., Drury, S., Fu, C. & Schmidt, A.M. (2000) Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: po- tential mechanisms underlying diabetic complica- tions, including diabetes-associated periodontitis. Periodontology 2000 23: 50-62.
18. Lekholm, U. (1993) The use of osseointegrated implants in growing jaws. International Journal of Oral & Maxillofacial Implants 8: 243-244.
19. Lu, H., Kraut, D., Gerstenfeld, L.C. & Graves, D.T. (2003) Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology 144: 346-352.
20. Margonar, R., Sakakura, C.E., Holzhausen, M., Pepato, M.T., Alba, R.C. & Marcantonio, E. (2003) The influence of diabetes mellitus and insulin therapy on biomechanical retention around dental implants: a study in rabbits. Implant Dentistry 12: 333-339.
21. McCracken, M.S., Aponte-Wesson, R., Chavali, R. & Lemons, J.E. (2006) Bone associated with implants in diabetic and insulin-treated rats. Clinical Oral Implants Research 17: 495-500.
22. McCracken, M., Lemons, J.E., Rahemtulla, F., Prince, C.W. & Feldman, D. (2000) Bone response to titanium alloy implants placed in diabetic rats. International Journal of Oral & Maxillofacial Implants 15: 345-354.
23. Mitruka, B.M. & Rawnsley, H.M. (1981) Clinical biochemical reference values. In: Clinical Biochemical and Hematological Reference Values in Normal Experimental Animals and Normal Humans, 2nd edition, 153-314. New York: Masson Publishing USA Inc.
24. de Morais, J.A.N.D., Trindade-Suedam, I.K., Pepato, M.T., Marcantonio, E. Jr, Wenzel, A. & Scaf, G. (2009) Effect of diabetes mellitus and insulin therapy on bone density around osseointegrated dental implants: a digital subtraction radiography study in rats. Clinical Oral Implants Research 20: 796-801.
25. Nevins, M.L., Karimbux, N.Y., Weber, H.P., Giannobile, W.V. & Fiorellini, J.P. (1998) Wound healing around endosseous implants in experimen- tal diabetes. International Journal of Oral & Maxillofacial Implants 13: 620-629.
26. Ottoni, C.E. & Chopard, R.P. (2004) Histomorphometric evaluation of new bone formation in diabetic rats submitted to insertion of temporary implants. Brazilian Dental Journal 15: 87-92.
27. Retzepi, M. & Donos, N. (2010) The effect of diabetes mellitus on osseous healing. Clinical Oral Implants Research 21: 673-681.
28. Sakakura, C.E., Marcantonio, E. Jr, Wenzel, A. & Scaf, G. (2007) Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits. Clinical Oral Implants Research 18: 34-39.
29. Sakakura, CE, Margonar, R, Holzhausen, M, Nociti, FH Jr, Alba, RC Jr & Marcantonio, E. Jr (2003) Influence of cyclosporin A therapy on bone healing around titanium implants: a histometric and biomechanic study in rabbits. Journal of Periodontology 74: 976-981.
30. Sakakura, CE, Margonar, R, Sartori, R, Morais, JA & Marcantonio, E. Jr (2006) The influence of cyclosporin a on mechanical retention of dental implants previously integrated to the bone: a study in rabbits. Journal of Periodontology 77: 2059-2062.
31. Santana, R.B., Xu, L., Chase, H.B., Amar, S., Graves, D.T. & Trackman, P.C. (2003) A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes 52: 1502-1510.
32. Schou, S., Holmstrup, P., Jorgensen, T., Stoltze, K., Hjorting-Hansen, E. & Wenzel, A. (2003) Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. I. Clinical and radiographic observations in cynomolgus monkeys. Clinical Oral Implants Research 14: 391-403.
33. Sennerby, L., Thomsen, P. & Ericson, L.E. (1992) A morphometric and biomechanic comparison of titanium implants inserted in rabbit cortical and cancellous bone. International Journal of Oral & Maxillofacial Implants 7: 62-71.
34. Shyng, Y.C., Devlin, H. & Sloan, P. (2001) The effect of streptozotocin-induced experimental diabetes mellitus on calvarial defect healing and bone turnover in the rat. International Journal of Oral and Maxillofacial Surgery 30: 70-74.
35. Siqueira, J.T., Cavalher-Machado, S.C., Arana-Chavez, V.E. & Sannomiya, P. (2003) Bone formation around titanium implants in the rat tibia: role of insulin. Implant Dentistry 12: 242-251.
36. Spanheimer, R.G., Umpierrez, G.E. & Stumpf, V. (1988) Decreased collagen production in diabetic rats. Diabetes 37: 371-376.
37. Takeshita, F., Iyama, S., Ayukawa, Y., Kido, M.A., Murai, K. & Suetsugu, T. (1997) The effects of diabetes on the interface between hydroxyapatite implants and bone in rat tibia. Journal of Periodontology 68: 180-185.
38. Taylor, G.W., Burt, B.A., Becker, M.P., Genco, R.J., Shlossman, M., Knowler, W.C. & Pettitt, D.J. (1998) Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. Journal of Periodontology 69: 76-83.
39. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183-1197.