-
1
-
-
42949160050
-
Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
-
Newman, D.J. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J. Med. Chem. 2008, 51, 2589-2599
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2589-2599
-
-
Newman, D.J.1
-
2
-
-
67650675111
-
Impact of natural products on developing new anti-cancer agents
-
Cragg, G.M.; Grothaus, P.G.; Newman, D.J. Impact of natural products on developing new anti-cancer agents. Chem. Rev. 2009, 109, 3012-3043
-
(2009)
Chem. Rev.
, vol.109
, pp. 3012-3043
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
3
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335
-
(2012)
J. Nat. Prod.
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
4
-
-
0034748170
-
The antihypertensive effects of stevioside derivative isosteviol in spontaneously hypertensive rats
-
Liu, J.C.; Kao, P.F.; Hsieh, M.H.; Chen, Y.J.; Chan, P. The antihypertensive effects of stevioside derivative isosteviol in spontaneously hypertensive rats. Acta Cardiol. Sin. 2001, 17, 133-140
-
(2001)
Acta Cardiol. Sin.
, vol.17
, pp. 133-140
-
-
Liu, J.C.1
Kao, P.F.2
Hsieh, M.H.3
Chen, Y.J.4
Chan, P.5
-
5
-
-
1542284229
-
Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells
-
Wong, K.L.; Yang, H.Y.; Chan, P.; Cheng, T.H.; Liu, J.C.; Hsu, F.L.; Liu, I.M.; Cheng, Y.W.; Cheng, J.T. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004, 70, 108-112
-
(2004)
Planta Med.
, vol.70
, pp. 108-112
-
-
Wong, K.L.1
Yang, H.Y.2
Chan, P.3
Cheng, T.H.4
Liu, J.C.5
Hsu, F.L.6
Liu, I.M.7
Cheng, Y.W.8
Cheng, J.T.9
-
6
-
-
34347386462
-
Isosteviol reduces plasma glucose levels in the intravenous glucose tolerance test in zucker diabetic fatty rats
-
Ma, J.; Ma, Z.; Wang, J.; Milne, R.W.; Xu, D.; Davey, A.K.; Evans, A.M. Isosteviol reduces plasma glucose levels in the intravenous glucose tolerance test in zucker diabetic fatty rats. Diabetes Obes. Metab. 2007, 9, 597-599
-
(2007)
Diabetes Obes. Metab.
, vol.9
, pp. 597-599
-
-
Ma, J.1
Ma, Z.2
Wang, J.3
Milne, R.W.4
Xu, D.5
Davey, A.K.6
Evans, A.M.7
-
7
-
-
33645984239
-
Antiproliferative effect of isosteviol on angiotensin-ii-treated rat aortic smooth muscle cells
-
Wong, K.L.; Lin, J.W.; Liu, J.C.; Yang, H.Y.; Kao, P.F.; Chen, C.H.; Loh, S.H.; Chiu, W.T.; Cheng, T.H.; Lin, J.G.; et al. Antiproliferative effect of isosteviol on angiotensin-ii-treated rat aortic smooth muscle cells. Pharmacology 2006, 76, 163-169
-
(2006)
Pharmacology
, vol.76
, pp. 163-169
-
-
Wong, K.L.1
Lin, J.W.2
Liu, J.C.3
Yang, H.Y.4
Kao, P.F.5
Chen, C.H.6
Loh, S.H.7
Chiu, W.T.8
Cheng, T.H.9
Lin, J.G.10
-
8
-
-
47249095856
-
The neuroprotective effects of isosteviol against focal cerebral ischemia injury induced by middle cerebral artery occlusion in rats
-
Xu, D.; Du, W.; Zhao, L.; Davey, A.K.; Wang, J. The neuroprotective effects of isosteviol against focal cerebral ischemia injury induced by middle cerebral artery occlusion in rats. Planta Med. 2008, 74, 816-821
-
(2008)
Planta Med.
, vol.74
, pp. 816-821
-
-
Xu, D.1
Du, W.2
Zhao, L.3
Davey, A.K.4
Wang, J.5
-
9
-
-
79960017502
-
Isosteviol as a starting material in organic synthesis
-
Moons, N.; de Borggraeve, W.; Dehaen, W. Isosteviol as a starting material in organic synthesis. Curr. Org. Chem. 2011, 15, 2731-2741
-
(2011)
Curr. Org. Chem.
, vol.15
, pp. 2731-2741
-
-
Moons, N.1
De Borggraeve, W.2
Dehaen, W.3
-
10
-
-
84882912019
-
(-)-isosteviol as a versatile ex-chiral-pool building block for organic chemistry
-
Lohoelter, C.; Weckbecker, M.; Waldvogel, S.R. (-)-isosteviol as a versatile ex-chiral-pool building block for organic chemistry. Eur. J. Org. Chem. 2013, 2013, 5539-5554
-
(2013)
Eur. J. Org. Chem.
, vol.2013
, pp. 5539-5554
-
-
Lohoelter, C.1
Weckbecker, M.2
Waldvogel, S.R.3
-
11
-
-
84867563740
-
Ent-kaurane diterpenoids and glycosides: Isolation, properties, and chemical transformations
-
Kataev, V.E.; Khaybullin, R.N.; Sharipova, R.R.; Strobykina, I.Y. Ent-kaurane diterpenoids and glycosides: Isolation, properties, and chemical transformations. Rev. J. Chem. 2011, 1, 93-160
-
(2011)
Rev. J. Chem.
, vol.1
, pp. 93-160
-
-
Kataev, V.E.1
Khaybullin, R.N.2
Sharipova, R.R.3
Strobykina, I.Y.4
-
12
-
-
84875927753
-
Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol
-
Hutt, O.E.; Doan, T.L.; Georg, G.I. Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol. Org. Lett. 2013, 15, 1602-1605
-
(2013)
Org. Lett.
, vol.15
, pp. 1602-1605
-
-
Hutt, O.E.1
Doan, T.L.2
Georg, G.I.3
-
13
-
-
35348947451
-
16-aza-ent-beyerane and 16-aza-ent-trachylobane: Potent mechanism-based inhibitors of recombinant ent-kaurene synthase from arabidopsis thaliana
-
Roy, A.; Roberts, F.G.; Wilderman, P.R.; Zhou, K.; Peters, R.J.; Coates, R.M. 16-aza-ent-beyerane and 16-aza-ent-trachylobane: Potent mechanism-based inhibitors of recombinant ent-kaurene synthase from arabidopsis thaliana. J. Am. Chem. Soc. 2007, 129, 12453-12460
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12453-12460
-
-
Roy, A.1
Roberts, F.G.2
Wilderman, P.R.3
Zhou, K.4
Peters, R.J.5
Coates, R.M.6
-
14
-
-
33847794267
-
Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids
-
Kataev, V.E.; Militsina, O.I.; Strobykina, I.Y.; Kovylyaeva, G.I.; Musin, R.Z.; Fedorova, O.V.; Rusinov, G.L.; Zeuva, M.N.; Mordovskoi, G.G.; Tolstikov, A.G. Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids. Pharm. Chem. J. 2006, 40, 473-475
-
(2006)
Pharm. Chem. J.
, vol.40
, pp. 473-475
-
-
Kataev, V.E.1
Militsina, O.I.2
Strobykina, I.Y.3
Kovylyaeva, G.I.4
Musin, R.Z.5
Fedorova, O.V.6
Rusinov, G.L.7
Zeuva, M.N.8
Mordovskoi, G.G.9
Tolstikov, A.G.10
-
15
-
-
84867857056
-
Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol
-
Khaybullin, R.N.; Strobykina, I.Y.; Dobrynin, A.B.; Gubaydullin, A.T.; Chestnova, R.V.; Babaev, V.M.; Kataev, V.E. Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol. Bioorg. Med. Chem. Lett. 2012, 22, 6909-6913
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 6909-6913
-
-
Khaybullin, R.N.1
Strobykina, I.Y.2
Dobrynin, A.B.3
Gubaydullin, A.T.4
Chestnova, R.V.5
Babaev, V.M.6
Kataev, V.E.7
-
16
-
-
84867923309
-
Unfolded and macrocyclic ammonium derivatives of diterpenoids steviol and isosteviol having choline moieties. Synthesis and inhibitory activities toward acetylcholine- and butyrylcholinesterases
-
Korochkina, M.G.; Nikitashina, A.D.; Khaybullin, R.N.; Petrov, K.A.; Strobykina, I.Y.; Zobov, V.V.; Kataev, V.E. Unfolded and macrocyclic ammonium derivatives of diterpenoids steviol and isosteviol having choline moieties. Synthesis and inhibitory activities toward acetylcholine- and butyrylcholinesterases. Med. Chem. Commun. 2012, 3, 1449-1454
-
(2012)
Med. Chem. Commun.
, vol.3
, pp. 1449-1454
-
-
Korochkina, M.G.1
Nikitashina, A.D.2
Khaybullin, R.N.3
Petrov, K.A.4
Strobykina, I.Y.5
Zobov, V.V.6
Kataev, V.E.7
-
17
-
-
84865512422
-
D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation
-
Zhang, T.; Lu, L.H.; Liu, H.; Wang, J.W.; Wang, R.X.; Zhang, Y.X.; Tao, J.C. D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation. Bioorg. Med. Chem. Lett. 2012, 22, 5827-5832
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 5827-5832
-
-
Zhang, T.1
Lu, L.H.2
Liu, H.3
Wang, J.W.4
Wang, R.X.5
Zhang, Y.X.6
Tao, J.C.7
-
18
-
-
84877870367
-
Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents
-
Zhu, S.L.; Wu, Y.; Liu, C.J.; Wei, C.Y.; Tao, J.C.; Liu, H.M. Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents. Eur. J. Med. Chem. 2013, 65, 70-82
-
(2013)
Eur. J. Med. Chem.
, vol.65
, pp. 70-82
-
-
Zhu, S.L.1
Wu, Y.2
Liu, C.J.3
Wei, C.Y.4
Tao, J.C.5
Liu, H.M.6
-
19
-
-
84874101284
-
Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines
-
Ukiya, M.; Sawada, S.; Kikuchi, T.; Kushi, Y.; Fukatsu, M.; Akihisa, T. Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines. Chem. Biodivers. 2013, 10, 177-188
-
(2013)
Chem. Biodivers.
, vol.10
, pp. 177-188
-
-
Ukiya, M.1
Sawada, S.2
Kikuchi, T.3
Kushi, Y.4
Fukatsu, M.5
Akihisa, T.6
-
20
-
-
84893783595
-
Synthesis and cytotoxic activity of mom-ether analogs of isosteviol
-
Malki, A.; Laha, R.; Bergmeier, S.C. Synthesis and cytotoxic activity of mom-ether analogs of isosteviol. Bioorg. Med. Chem. Lett. 2014, 24, 1184-1187
-
(2014)
Bioorg. Med. Chem. Lett.
, vol.24
, pp. 1184-1187
-
-
Malki, A.1
Laha, R.2
Bergmeier, S.C.3
-
21
-
-
84855756802
-
Synthesis of a biologically active triazole-containing analogue of cystatin a through successive peptidomimetic alkyne-azide ligations
-
Valverde, I.E.; Lecaille, F.; Lalmanach, G.; Aucagne, V.; Delmas, A.F. Synthesis of a biologically active triazole-containing analogue of cystatin a through successive peptidomimetic alkyne-azide ligations. Angew. Chem. Int. Ed. Engl. 2012, 51, 718-722
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 718-722
-
-
Valverde, I.E.1
Lecaille, F.2
Lalmanach, G.3
Aucagne, V.4
Delmas, A.F.5
-
22
-
-
56249112956
-
Novel anthraquinone derivatives: Synthesis via click chemistry approach and their induction of apoptosis in bgc gastric cancer cells via reactive oxygen species (ros)-dependent mitochondrial pathway
-
Wang, S.; Wang, Q.; Wang, Y.; Liu, L.; Weng, X.; Li, G.; Zhang, X.; Zhou, X. Novel anthraquinone derivatives: Synthesis via click chemistry approach and their induction of apoptosis in bgc gastric cancer cells via reactive oxygen species (ros)-dependent mitochondrial pathway. Bioorg. Med. Chem. Lett. 2008, 18, 6505-6508
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 6505-6508
-
-
Wang, S.1
Wang, Q.2
Wang, Y.3
Liu, L.4
Weng, X.5
Li, G.6
Zhang, X.7
Zhou, X.8
-
23
-
-
84863483350
-
Click" synthesis of a triazole-based inhibitor of met functions in cancer cells
-
Colombo, F.; Tintori, C.; Furlan, A.; Borrelli, S.; Christodoulou, M.S.; Dono, R.; Maina, F.; Botta, M.; Amat, M.; Bosch, J.; et al. "Click" synthesis of a triazole-based inhibitor of met functions in cancer cells. Bioorg. Med. Chem. Lett. 2012, 22, 4693-4696
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 4693-4696
-
-
Colombo, F.1
Tintori, C.2
Furlan, A.3
Borrelli, S.4
Christodoulou, M.S.5
Dono, R.6
Maina, F.7
Botta, M.8
Amat, M.9
Bosch, J.10
-
24
-
-
80055001778
-
N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of bcr-abl
-
Arioli, F.; Borrelli, S.; Colombo, F.; Falchi, F.; Filippi, I.; Crespan, E.; Naldini, A.; Scalia, G.; Silvani, A.; Maga, G.; et al. N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of bcr-abl. ChemMedChem 2011, 6, 2009-2018
-
(2011)
ChemMedChem
, vol.6
, pp. 2009-2018
-
-
Arioli, F.1
Borrelli, S.2
Colombo, F.3
Falchi, F.4
Filippi, I.5
Crespan, E.6
Naldini, A.7
Scalia, G.8
Silvani, A.9
Maga, G.10
-
25
-
-
84861595329
-
Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry
-
Zhang, Y.; Lv, Z.; Zhong, H.; Geng, D.; Zhang, M.; Zhang, T.; Li, Y.; Li, K. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. Eur. J. Med. Chem. 2012, 53, 356-363
-
(2012)
Eur. J. Med. Chem.
, vol.53
, pp. 356-363
-
-
Zhang, Y.1
Lv, Z.2
Zhong, H.3
Geng, D.4
Zhang, M.5
Zhang, T.6
Li, Y.7
Li, K.8
-
26
-
-
84894620086
-
Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid
-
Pertino, M.W.; Verdugo, V.; Theoduloz, C.; Schmeda-Hirschmann, G. Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid. Molecules 2014, 19, 2523-2535
-
(2014)
Molecules
, vol.19
, pp. 2523-2535
-
-
Pertino, M.W.1
Verdugo, V.2
Theoduloz, C.3
Schmeda-Hirschmann, G.4
-
27
-
-
84879468718
-
Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents
-
Rashid, S.; Dar, B.A.; Majeed, R.; Hamid, A.; Bhat, B.A. Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. Eur. J. Med. Chem. 2013, 66, 238-245
-
(2013)
Eur. J. Med. Chem.
, vol.66
, pp. 238-245
-
-
Rashid, S.1
Dar, B.A.2
Majeed, R.3
Hamid, A.4
Bhat, B.A.5
-
28
-
-
0001387760
-
Hydrolysis of the diterpenoid glycoside, stevioside
-
Avent, A.G.; Hanson, J.R.; Deoliveira, B.H. Hydrolysis of the diterpenoid glycoside, stevioside. Phytochemistry 1990, 29, 2712-2715
-
(1990)
Phytochemistry
, vol.29
, pp. 2712-2715
-
-
Avent, A.G.1
Hanson, J.R.2
Deoliveira, B.H.3
-
29
-
-
84868602724
-
Fused derivatives of (iso)steviol via pericyclic reactions
-
Moons, N.; Goyens, D.; Jacobs, J.; van Meervelt, L.; De Borggraeve, W.M.; Dehaen, W. Fused derivatives of (iso)steviol via pericyclic reactions. Tetrahedron Lett. 2012, 53, 6806-6809
-
(2012)
Tetrahedron Lett.
, vol.53
, pp. 6806-6809
-
-
Moons, N.1
Goyens, D.2
Jacobs, J.3
Van Meervelt, L.4
De Borggraeve, W.M.5
Dehaen, W.6
-
30
-
-
80051767323
-
Acid-base jointly promoted copper(I)-catalyzed azide-alkyne cycloaddition
-
Shao, C.; Wang, X.; Zhang, Q.; Luo, S.; Zhao, J.; Hu, Y. Acid-base jointly promoted copper(I)-catalyzed azide-alkyne cycloaddition. J. Org. Chem. 2011, 76, 6832-6836
-
(2011)
J. Org. Chem.
, vol.76
, pp. 6832-6836
-
-
Shao, C.1
Wang, X.2
Zhang, Q.3
Luo, S.4
Zhao, J.5
Hu, Y.6
-
31
-
-
64549113757
-
Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes
-
Campbell-Verduyn, L.S.; Mirfeizi, L.; Dierckx, R.A.; Elsinga, P.H.; Feringa, B.L. Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes. Chem. Commun. 2009, 2139-2141
-
(2009)
Chem. Commun.
, pp. 2139-2141
-
-
Campbell-Verduyn, L.S.1
Mirfeizi, L.2
Dierckx, R.A.3
Elsinga, P.H.4
Feringa, B.L.5
-
32
-
-
0037071180
-
A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides
-
Rijkers, D.T.S.; van Vugt, H.H.R.; Jacobs, H.J.F.; Liskamp, R.M.J. A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides. Tetrahedron Lett. 2002, 43, 3657-3660
-
(2002)
Tetrahedron Lett.
, vol.43
, pp. 3657-3660
-
-
Rijkers, D.T.S.1
Van Vugt, H.H.R.2
Jacobs, H.J.F.3
Liskamp, R.M.J.4
-
33
-
-
24044531286
-
Organic azides: An exploding diversity of a unique class of compounds
-
Brase, S.; Gil, C.; Knepper, K.; Zimmermann, V. Organic azides: An exploding diversity of a unique class of compounds. Angew. Chem. Int. Ed. Engl. 2005, 44, 5188-5240
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 5188-5240
-
-
Brase, S.1
Gil, C.2
Knepper, K.3
Zimmermann, V.4
-
34
-
-
33845278154
-
Azides-Their preparation and synthetic uses
-
Scriven, E.F.V.; Turnbull, K. Azides-Their preparation and synthetic uses. Chem. Rev. 1988, 88, 297-368
-
(1988)
Chem. Rev.
, vol.88
, pp. 297-368
-
-
Scriven, E.F.V.1
Turnbull, K.2
-
35
-
-
70350175456
-
Part 1. Lab-scale synthesis of azido compounds: Safety measures and analysis
-
1st ed.; John Wiley & Sons: West Sussex, UK
-
Bräse, S.; Banert, K. Part 1. Lab-scale synthesis of azido compounds: Safety measures and analysis. In Organic Azides: Syntheses and Applications, 1st ed.; John Wiley & Sons: West Sussex, UK, 2009; Volume 1, pp. 3-27.
-
(2009)
Organic Azides: Syntheses and Applications
, vol.1
, pp. 3-27
-
-
Bräse, S.1
Banert, K.2
|