Identification of a putative tdp1 inhibitor (CD00509) by in vitro and cell-based assays

Journal of Biomolecular Screening

Volumn 19, Issue 10, 2014, Pages 1372-1382

  Dean, Richard A ^a   Fam, Hok Khim ^b,c   An, Jianghong ^d   Choi, Kunho ^b,c   Shimizu, Yoko ^a   Jones, Steven J M ^c,d,e   Boerkoel, Cornelius F ^b,c   Interthal, Heidrun ^f   Pfeifer, Tom A ^a  

^a 2405 Wesbrook Mall   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e SIMON FRASER UNIVERSITY   (Canada)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

cancer and cancer drugs; cell based assays; compound repositories; high content screening

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; CASPASE 7; CD 00509; DNA TOPOISOMERASE INHIBITOR; GAMMA H2AX PROTEIN; HISTONE H2AX; PHOSPHODIESTERASE INHIBITOR; RUCAPARIB; TOPOISOMERASE 1 INHIBITOR; UNCLASSIFIED DRUG; CD00509; H2AFX PROTEIN, HUMAN; HISTONE; PHOSPHODIESTERASE; PYRAN DERIVATIVE; TDP1 PROTEIN, HUMAN; TDP1 PROTEIN, MOUSE; THIOBARBITURIC ACID DERIVATIVE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOFLUORESCENCE; BREAST CANCER; BREAST CANCER CELL LINE; BREAST EPITHELIUM; CELL ASSAY; CELL BASED ASSAY; CELL COUNT; CELL PROLIFERATION; COLORIMETRY; COMET ASSAY; CONTROLLED STUDY; DNA FRAGMENTATION; DNA REPAIR; DNA STRAND BREAKAGE; DRUG IDENTIFICATION; DRUG SCREENING; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST; FOLLOW UP; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CANCER; MCF 7 CELL LINE; MOUSE; MTT ASSAY; NICK END LABELING; NON SMALL CELL LUNG CANCER; NONHUMAN; OVARY CANCER; PROTEIN EXPRESSION; RHABDOMYOSARCOMA; STRUCTURE ACTIVITY RELATION; THYROID CANCER; ANIMAL; BREAST NEOPLASMS; CHEMISTRY; COMPUTER SIMULATION; DNA DAMAGE; DRUG EFFECTS; FEMALE; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR DOCKING; NEOPLASM; PATHOLOGY; PROCEDURES; TISSUE MICROARRAY;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL PROLIFERATION; COMPUTER SIMULATION; DNA DAMAGE; FEMALE; GENE KNOCKDOWN TECHNIQUES; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONES; HUMANS; IN VITRO TECHNIQUES; MCF-7 CELLS; MICE; MOLECULAR DOCKING SIMULATION; NEOPLASMS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRANS; THIOBARBITURATES; TISSUE ARRAY ANALYSIS; TOPOISOMERASE I INHIBITORS;

EID: 84912050841     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114546551     Document Type: Article

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