Metabolic syndrome and the environmental pollutants from mitochondrial perspectives

Reviews in Endocrine and Metabolic Disorders

Volumn 15, Issue 4, 2014, Pages 253-262

  Kim, Jin Taek ^a   Lee, Hong Kyu ^a  

^a Eulji University School of Medicine   (South Korea)

Author keywords

Endocrine disrupting chemicals (EDCs); Insulin resistance; Metabolic syndrome; Mitochondrial dysfunction; Persistent organic pollutants (POPs)

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; ACID; ANTIRETROVIRUS AGENT; ARSENIC; ATRAZINE; CADMIUM; DIOXIN; DRUG; ENDOCRINE DISRUPTOR; FIPRONIL; FLAME RETARDANT; HEAVY METAL; HERBICIDE; IMIDACLOPRID; INSECTICIDE; MERCURY; METALLOID; NON PERSISTING ENDOCRINE DISRUPTOR; ORGANIC COMPOUND; ORGANOCHLORINE DERIVATIVE; ORGANOTIN COMPOUND; PERSISTING ENDOCRINE DISRUPTOR; PESTICIDE; PHTHALIC ACID; PLASTICIZER; RODENTICIDE; UNCLASSIFIED DRUG; POLLUTANT;

AIR POLLUTANT; AIR POLLUTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXERCISE; GENOTYPE; HORMONE ACTION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC SYNDROME X; METABOLISM; MITOCHONDRIAL GENOME; MITOCHONDRIAL HAPLOGROUP; NONHUMAN; OBESITY; OVERNUTRITION; OXYGEN CONSUMPTION; PERSISTENT ORGANIC POLLUTANT; PHENOTYPE; POLLUTANT; REVIEW; SEDENTARY LIFESTYLE; TOXIC WASTE; WEIGHT CHANGE; ADVERSE EFFECTS; DRUG EFFECTS; MITOCHONDRION;

ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; HUMANS; INSULIN RESISTANCE; METABOLIC SYNDROME X; MITOCHONDRIA;

EID: 84911961043     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-014-9297-5     Document Type: Review

References (75)

1. Meigs JB. Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am JEpidemiol. 2000;152:908–11.
2. Reaven GM. Banting lecture, Role of insulin resistance in human disease. Diabetes. 1998;37:1595–607.
3. Lee HK, Cho YM, Kwak SH, Lim S, Park KS, Shim EB. Mitochondrial dysfunction and metabolic syndrome-looking for environmental factors. Biochim Biophys Acta. 2010;1800(3):282–9.
4. Lee HK, Shim EB. Extension of Mitochondria Dysfunction Hypothesis of Metabolic Syndrome to Atherosclerosis with Emphasis on the Endocrine Disrupting Chemicals and Biophysical Laws. J Diabetes Investig. 2013;4(1):19–33.
5. Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17.
6. Lee DH, Porta M, Jacobs Jr DR, Vandenberg LN. Chlorinated persistent organic pollutants, obesity, and type 2 diabetes. Endocr Rev. 2014;35(4):557–601.
7. Lee HK, Song JH, Shin CS, Park DJ, Park KS, Lee KU, et al. Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1998;42:161–7.
8. Jucker BM, Dufour S, Ren J, Cao X, Previs SF, Underhill B, et al. Shulman GI.Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR. Proc Natl Acad Sci U S A. 2000;97:6880–4.
9. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science. 2003;300:1140–2.
10. Smith RE. Quantitative relations between liver mitochondria metabolism and total body weight in mammals. Ann NY Acad Sci. 1956;62:403–22.
11. Rasmussen UF, Rasmussen HN, Krustrup P, Quistorff B, Saltin B, Bangsbo J. Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria. Am J Physiol Endocrinol Metab. 2001;280:301–7.
12. Lee HK. Method of proof and evidences for the concept that mitochondrial genome is a thrifty genome. Diabetes Res Clin Pract. (Suppl. 2) 2001;54–63.
13. Kleiber M. Body size and metabolism. Hilgardia. 1932;6:315–53.
14. West GB, Woodruff WH, Brown JH. Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proc Natl Acad Sci U S A. 2002;99 Suppl 1:2473–8.
15. Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WG, et al. Reduced rate of energy expenditure as a risk factor for bodyweight gain. N Engl J Med. 1988;318:467–72.
16. Chun PW. Why does the human body maintain a constant 37-degree temperature?: thermodynamic switch controls chemical equilibrium in biological systems. Phys Scr. 2005;118:219–22.
17. Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010;31(3):364–95.
18. Szendroedi J, Phielix E, Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2012;8(2):92–103.
19. Pravenec M, Hyakukoku M, Houstek J, Zidek V, Landa V, Mlejnek P, et al. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Genome Res. 2007;17:1319–26.
20. Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, et al. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet. 2007;80:407–15.
21. Park KS, Chan JC, Chuang LM, Suzuki S, Araki E, Nanjo K, et al. A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia. 2008;51:602–8.
22. Flaquer A, Baumbach C, Kriebel J, Meitinger T, Peters A, Waldenberger M, et al. Mitochondrial Genetic Variants Identified to Be Associated with BMI in Adults. PLoS One. 2014;9(8):e105116.
23. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992;35:595–601.
24. Knowler WC, Pettitt DJ, Bennett PH, Williams RC. Diabetes mellitus in the Pima Indians: genetic and evolutionary considerations. Am J Phys Anthropol. 1983;62:107–14.
25. Cannon B, Nedergaard J. Thermogenesis challenges the adipostat hypothesis for body-weight control. Proc Nutr Soc. 2009;68(4):401–7.
26. Koleva DI, Orbetzova MM, Atanassova PK. Adipose tissue hormones and appetite and body weight regulators in insulin resistance. Folia Med (Plovdiv). 2013;55(1):25–32.
27. Krebs HA, Eggleston LV. The effect of insulin on oxidations in isolated muscle tissue. Biochem J. 1938;32(5):913913.
28. Echave P1, Machado-da-Silva G, Arkell RS, Duchen MR, Jacobson J, Mitter R, et al. Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis. J Cell Sci. 2009;122(24):4516–22.
29. Damstra T, Barlow S, Aake B, Kavlock R, Van Der Kraak G. International Programme on Chemical Safety: Global Assessment of the State-of-the-Science on Endocrine Disruptors. 2002. http://www.who.int/pcs/emerg_site/edc/global_edc_TOC.htm
30. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect. 2012;120(6):779–89.
31. Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicol Pathol. 2013;41(2):361–73.
32. Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999–2002. Diabetes Care. 2006;29(7):1638–44.
33. Ruzzin J, Petersen R, Meugnier E, Madsen L, Lock EJ, Lillefosse H, et al. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect. 2010;118(4):465–71.
34. Virtanen MT. Histopathological and ultrastructural changes in the gills of Poeciliareticulatus induced by an organochlorine pesticide. J Environ Pathol Toxicol Oncol. 1986;7:73–85.
35. Shertzer HG, Genter MB, Shen D, Nebert DW, Chen Y, Dalton TP. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F (0) F (1)-ATP synthase and ubiquinone. Toxicol Appl Pharmacol. 2006;217:363–74.
36. Nakagawa Y, Suzuki T, Ishii H, Ogata A. Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes. Xenobiotica. 2007;37:693–708.
37. Lind L, Zethelius B, Salihovic S, van Bavel B, Lind PM. Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly. Diabetologia. 2014;57(3):473–9.
38. Esposti MD, Ngo A, Myers MA. Inhibition of mitochondrial complex I may account for IDDM induced by intoxication with the rodenticide Vacor. Diabetes. 1996;45:1531–4.
39. Rahimi R, Abdollahi MA. review on the mechanism involved in hyperglycaemia induced by organophosphorus pesticides. Pestic Biochem Physiol. 2007;88:115–21.
40. Karami-Mohajeri S, Hadian MR, Fouladdel S, Azizi E, Ghahramani MH, Hosseini R, et al. Mechanisms of muscular electrophysiological and mitochondrial dysfunction following exposure tomalathion, an organophosphorus pesticide. Hum ExpToxicol. 2014;33(3):251–63.
41. McKinlay R, Plant JA, Bell JNB, Voulvoulis N. Endocrine disrupting pesticides: implications for risk assessment. Environ Int. 2008;34:168–83.
42. Jeong SH, Kim BY, Kang HG, Ku HK, Cho JH. Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0− andF1-generations. Toxicology. 2006;220:189–202.
43. Soloman KR, Baker DB, Richards RP, Dixon KR, Klaine SJ. Ecological risk assessment of atrazine in North American surface waters. Environ Toxicol Chem. 1996;15:31–76.
44. Lim S, Ahn SY, Song IC, Chung MH, Jang HC, Park KS, et al. Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One. 2009;4(4):e5186.
45. Nicodemo D, Maioli MA, Medeiros HC, Guelfi M, Balieira KV, De Jong D, et al. Fipronil and imidacloprid reduce honeybee mitochondrial activity. Environ Toxicol Chem. 2014;33(9):2070–5.
46. Lind PM, Zethelius B. Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly. Diabetes Care. 2012;35(7):1519–24.
47. Hurst CH, Waxman DJ. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci. 2003;74:297–308.
48. Bility MT, Thompson JT, McKee RH, David RM, Butala JH, VandenHeuvel JP. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci. 2004;82:170.182.
49. Posnack NG, Swift LM, Kay MW, Lee NH, Sarvazyan N. Phthalate exposure changes the metabolic profile of cardiac muscle cells. Environ Health Perspect. 2012;120(9):1243–51.
50. Ishido M, Suzuki J. Classification of phthalates based on an in vitro neurosphere assay using rat mesencephalic neural stem cells. J Toxicol Sci. 2014;39(1):25–32.
51. Goodman M, Lakind JS, Mattison DR. Do phthalates act as obesogens in humans? A systematic review of the epidemiological literature. Crit Rev Toxicol. 2014;44(2):151–75.
52. Polyzos SA, Kountouras J, Deretzi G, Zavos C, Mantzoros CS. The emerging role of endocrine disruptors in pathogenesis of insulin resistance: a concept implicating nonalcoholic fatty liver disease. Curr Mol Med. 2012;12(1):68–82.
53. Alonso-Magdalena P, Quesada I, Nadal A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat Rev Endocrinol. 2011;7(6):346–53.
54. Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, et al. Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. J Korean Med Sci. 2012;27(6):644–552.
55. Kaur K, Chauhan V, Gu F, Chauhan A. Bisphenol A induces oxidative stress and mitochondrial dysfunction in lymphoblasts from children with autism and unaffected siblings. Free Radic Biol Med. 2014;76C:25–33.
56. Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH. Heavy metals and islet function and diabetes development. Islets. 2009;1:169–76.
57. Edwards JR, Prozialeck WC. Cadmium, diabetes and chronic kidney disease. Toxicol Appl Pharmacol. 2009;238:289–93.
58. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol. 2011;31(2):95–107.
59. Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicol Pathol. 2013;41(2):361–73.
60. Andersen ZJ, Raaschou-Nielsen O, Ketzel M, Jensen SS, Hvidberg M, Loft S, et al. Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes Care. 2012;35(1):92–8.
61. Coogan PF, White LF, Jerrett M, Brook RD, Su JG, Seto E, et al. Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles. Circulation. 2012;125(6):767–72.
62. Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, et al. Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Part Fibre Toxicol. 2014; 11:27.
63. Adar SD, Filigrana PA, Clements N, Peel JL. Ambient Coarse Particulate Matter and Human Health: A Systematic Review and Meta-Analysis. Curr Environ Health Rep. 2014;8(1):258–74.
64. Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat Rev Drug Discov. 2003;2:812–22.
65. Gerschenson M, Kim C, Berzins B, Taiwo B, Libutti DE J, Choi J, et al. Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen. J Antimicrob Chemother. 2009;63:1244–50.
66. Boelsterli UA, Lim PL. Mitochondrial abnormalities-a link to idiosyncratic drug hepatotoxicity? Toxicol Appl Pharmacol. 2007;220:92–107.
67. Amacher DE. Drug-associated mitochondrial toxicity and its detection. Curr Med Chem. 2005;12(16):1829–39.
68. Hectors TL, Vanparys C, Van Gaal LF, Jorens PG, Covaci A, Blust R. Insulin resistance and environmental pollutants: experimental evidence and future perspectives. Environ Health Perspect. 2013;121(11–12):1273–81.
69. Park WH, Jun DW, Kim JT, Jeong JH, Park H, Chang YS, et al. Novel cell-based assay reveals associations of circulating serum AhR-ligands with metabolic syndrome and mitochondrial dysfunction. Biofactors. 2013;39(4):494–504.
70. Shanle EK, Xu W. Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem Res Toxicol. 2011;24(1):6–19.
71. Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, et al. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice. PLoS One. 2013;8(4):e61802.
72. Gao J, Xie W. Targeting xenobiotic receptors PXR and CAR for metabolic diseases. Trends Pharmacol Sci. 2012;33(10):552–8.
73. Pereira-Fernandes A, Demaegdt H, Vandermeiren K, Hectors TL, Jorens PG, Blust R, et al. Evaluation of screening system for obesogenic compounds: screening of endocrinedisrupting compounds and evaluation of the PPAR dependency of the effect. PLoS One. 2013;8(10):e77481.
74. Patel CJ, Bhattacharya J, Butte AJ. An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One. 2010;5(5):e10746.
75. Kim JT, Kim SS, Jun DW, Hwang YH, Park WH, Pak YK, et al. Serum arylhydrocarbon receptor transactivating activity is elevated in type 2 diabetic patients with diabetic nephropathy. J Diabetes Investig. 2013;4(5):483–91.