Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate

International Journal of Pharmaceutics

Volumn 478, Issue 1, 2015, Pages 103-112

  Li, Meng ^a   Gogos, Costas G ^a,b   Ioannidis, Nicolas ^b  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^b Polymer Processing Institute   (United States)

Author keywords

Amorphous solid dispersions; Dissolution rate; Flowability; Hot melt extrusion; Particle size; Screw configuration

Indexed keywords

PARACETAMOL; EXCIPIENT; MACROGOL DERIVATIVE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE;

ANGLE OF REPOSE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STABILITY; MICROSCOPY; PARTICLE SIZE; PHARMACEUTICAL HOT MELT EXTRUSION; PHARMACOLOGICAL PROCEDURES; THERMOSTABILITY; CHEMISTRY; DEVICES; HEAT; PHARMACEUTICS; POLARIZATION MICROSCOPY; PROCEDURES; SOLUBILITY;

ACETAMINOPHEN; CALORIMETRY, DIFFERENTIAL SCANNING; EXCIPIENTS; HOT TEMPERATURE; MICROSCOPY, POLARIZATION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYVINYLS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84911949824     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.024     Document Type: Article

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