Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2

Neuropharmacology

Volumn 71, Issue , 2013, Pages 124-129

  Engström Ruud, Linda ^a   Wilhelms, Daniel Björk ^a   Eskilsson, Anna ^a   Vasilache, Ana Maria ^a   Elander, Louise ^a   Engblom, David ^a   Blomqvist, Anders ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Cyclooxygenase 1; Cyclooxygenase 2; E synthase 1; Fever; Gene dosage; Hypothalamus; Microsomal prostaglandin

Indexed keywords

CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; PARACETAMOL; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG DOSE TITRATION; DRUG MEGADOSE; ENZYME INHIBITION; FEVER; HETEROZYGOTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELEMETRY;

ACETAMINOPHEN; ANIMALS; ANTIPYRETICS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEVER; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HETEROZYGOTE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; INTRAMOLECULAR OXIDOREDUCTASES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED DBA; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; PROSENCEPHALON;

EID: 84878157578     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.03.012     Document Type: Article

References (39)

1. D.G. Altman Practical Statistics for Medical Research 1991 Chapman and Hall London
2. D.A. Andersson, C. Gentry, L. Alenmyr, D. Killander, S.E. Lewis, A. Andersson, B. Bucher, J.-L. Galzi, O. Sterner, S. Bevan, E.D. Högestätt, and P.M. Zygmunt TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol Nat. Commun. 2 2011 551
3. M. Bisaglia, V. Venezia, P. Piccioli, S. Stanzione, C. Porcile, C. Russo, F. Mancini, C. Milanese, and G. Schettini Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid β-peptides induced oxidative stress and reduces NF-κB activation Neurochem. Int. 41 2002 43 54
4. J. Bonnefont, L. Daulhac, M. Etienne, E. Chapuy, C. Mallet, L. Ouchchane, C. Deval, J.-P. Courade, M. Ferrara, A. Eschalier, and E. Clottes Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system Mol. Pharmacol. 71 2007 407 415
5. 2+-dependent phospholipase A2 J. Neurochem. 91 2004 1389 1397
6. O. Boutaud, D.M. Aronoff, J.H. Richardson, L.J. Marnett, and J.A. Oates Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases Proc. Natl. Acad. Sci. U. S. A. 99 2002 7130 7135
7. N.V. Chandrasekharan, H. Dai, K.L.T. Roos, N.K. Evanson, J. Tomsik, T.S. Elton, and D.L. Simmons COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression Proc. Natl. Acad. Sci. U. S. A. 99 2002 13926 13931
8. J.P. Courade, D. Besse, C. Delchambre, N. Hanoun, M. Hamon, A. Eschalier, F. Caussade, and A. Cloarec Acetaminophen distribution in the rat central nervous system Life Sci. 69 2001 1455 1464
9. M. Ek, D. Engblom, S. Saha, A. Blomqvist, P.J. Jakobsson, and A. Ericsson-Dahlstrand Inflammatory response: pathway across the blood-brain barrier Nature 410 2001 430 431
10. D. Engblom, S. Saha, L. Engstrom, M. Westman, L.P. Audoly, P.J. Jakobsson, and A. Blomqvist Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis Nat. Neurosci. 6 2003 1137 1138
11. 2 production specifically in brain endothelial cells Endocrinology 153 2012 4849 4861
12. R.J. Flower, and J.R. Vane Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol) Nature 240 1972 410 411
13. G. Giaever, D.D. Shoemaker, T.W. Jones, H. Liang, E.A. Winzeler, A. Astromoff, and R.W. Davis Genomic profiling of drug sensitivities via induced haploinsufficiency Nat. Genet. 21 1999 278 283
14. B. Hinz, O. Cheremina, and K. Brune Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man FASEB J. 22 2008 383 390
15. C.-C. Hou, H. Lin, C.-P. Chang, W.-T. Huang, and M.-T. Lin Oxidative stress and pyrogenic fever pathogenesis Eur. J. Pharmacol. 667 2011 6 12
16. W. Inoue, K. Matsumura, K. Yamagata, T. Takemiya, T. Shiraki, and S. Kobayashi Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever Neurosci. Res. 44 2002 51 61
17. A.I. Ivanov, R.S. Pero, A.C. Scheck, and A.A. Romanovsky Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation Am. J. Physiol. Regul. Integr. Comp. Physiol. 283 2002 R1104 R1117
18. B. Kis, J.A. Snipes, and D.W. Busija Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties J. Pharmacol. Exp. Ther. 315 2005 1 7
19. E. Kumpulainen, H. Kokki, T. Halonen, M. Heikkinen, J. Savolainen, and M. Laisalmi Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration Pediatrics 119 2007 766 771
20. S. Li, W. Dou, Y. Tang, S. Goorha, L.R. Ballou, and C.M. Blatteis Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant Prostaglandins Other Lipid Mediat. 85 2008 89 99
21. S. Li, Y. Wang, K. Matsumura, L.R. Ballou, S.G. Morham, and C.M. Blatteis The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice Brain Res. 825 1999 86 94
22. H. Maharaj, D.S. Maharaj, and S. Daya Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity Metab. Brain Dis. 21 2006 180 190
23. F. Mancini, C. Landolfi, M. Muzio, L. Aquilini, L. Soldo, I. Coletta, A. Guglielmotti, A. Mantovani, M. Pinza, and C. Milanese Acetaminophen down-regulates interleukin-1β-induced nuclear factor-κB nuclear translocation in a human astrocytic cell line Neurosci. Lett. 353 2003 79 82
24. J.A. Mitchell, P. Akarasereenont, C. Thiemermann, R.J. Flower, and J.R. Vane Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase Proc. Natl. Acad. Sci. U. S. A. 90 1993 11693 11697
25. S.G. Morham, R. Langenbach, C.D. Loftin, H.F. Tiano, N. Vouloumanos, J.C. Jennette, J.F. Mahler, K.D. Kluckman, A. Ledford, C.A. Lee, and O. Smithies Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse Cell 83 1995 473 482
26. K. Muller-Decker Cyclooxygenases F. Marks, G. Furstenberger, Prostaglandins, Leukotrienes, and Other Eicosanoids 1999 Wiley-VCH Weinheim 65 88
27. A. Nadjar, V. Tridon, M.J. May, S. Ghosh, R. Dantzer, T. Amedee, and P. Parnet NF[kappa]B activates in vivo the synthesis of inducible Cox-2 in the brain J. Cereb. Blood Flow Metab. 25 2005 1047 1059
28. 2 Endocrinology 150 2009 1850 1860
29. C. Nilsberth, N. Hamzic, M. Norell, and A. Blomqvist Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1 J. Neuroendocrinol. 21 2009 715 721
30. M. Ouellet, and M.D. Percival Mechanism of acetaminophen inhibition of cyclooxygenase isoforms Arch. Biochem. Biophys. 387 2001 273 280
31. W. Riedel, U. Lang, U. Oetjen, U. Schlapp, and M. Shibata Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever Mol. Cell. Biochem. 247 2003 83 94
32. A.A. Romanovsky, V.A. Kulchitsky, C.T. Simons, and N. Sugimoto Methodology of fever research: why are polyphasic fevers often thought to be biphasic? Am. J. Physiol. 275 1998 R332 R338
33. A.Y. Rudaya, A.A. Steiner, J.R. Robbins, A.S. Dragic, and A.A. Romanovsky Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 2005 R1244 R1252
34. S. Saha, L. Engstrom, L. Mackerlova, P.J. Jakobsson, and A. Blomqvist Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1 Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 2005 R1100 R1107
35. S. Thoren, and P.J. Jakobsson Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4 Eur. J. Biochem. 267 2000 6428 6434
36. C.E. Trebino, J.L. Stock, C.P. Gibbons, B.M. Naiman, T.S. Wachtmann, J.P. Umland, K. Pandher, J.M. Lapointe, S. Saha, M.L. Roach, D. Carter, N.A. Thomas, B.A. Durtschi, J.D. McNeish, J.E. Hambor, P.J. Jakobsson, T.J. Carty, J.R. Perez, and L.P. Audoly Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase Proc. Natl. Acad. Sci. U. S. A. 100 2003 9044 9049
37. D. Tripathy, and P. Grammas Acetaminophen protects brain endothelial cells against oxidative stress Microvasc. Res. 77 2009 289 296
38. J.R. Vane Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nat. New Biol. 231 1971 232 235
39. K. Yamagata, K. Matsumura, W. Inoue, T. Shiraki, K. Suzuki, S. Yasuda, H. Sugiura, C. Cao, Y. Watanabe, and S. Kobayashi Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever J. Neurosci. 21 2001 2669 2677