Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever

Journal of Neuroscience

Volumn 34, Issue 35, 2014, Pages 11684-11690

  Wilhelms, Daniel Björk ^a   Kirilov, Milen ^a,d   Mirrasekhian, Elahe ^a   Eskilsson, Anna ^a   Kugelberg, Unn Örtegren ^a   Klar, Christine ^a   Ridder, Dirk A ^b   Herschman, Harvey R ^c   Schwaninger, Markus ^b   Blomqvist, Anders ^a   Engblom, David ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

COX 2; Endothelium; Fever; mPGES 1; Prostaglandin

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; LIPOCALIN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; ISOMERASE; PROSTAGLANDIN; PROSTAGLANDIN E SYNTHASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DNA MODIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HYPOACTIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LOCOMOTION; MOUSE; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SOUTHERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COX-2; ENDOTHELIUM; ENDOTHELIUM CELL; KNOCKOUT MOUSE; METABOLISM; MPGES-1;

COX-2; ENDOTHELIUM; FEVER; MPGES-1; PGE2; PROSTAGLANDIN;

ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEVER; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION;

EID: 84906545738     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1838-14.2014     Document Type: Article

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