Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat

Toxicological Sciences

Volumn 141, Issue 2, 2014, Pages 524-537

  Beverly, Brandiese E J ^a,b   Lambright, Christy S ^a   Furr, Johnathan R ^a   Sampson, Hunter ^a   Wilson, Vickie S ^a   McIntyre, Barry S ^c   Foster, Paul M D ^c   Travlos, Gregory ^c   Gray, L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cholesterol; Phthalates; Sexual differentiation; Simvastatin; Steroidogenesis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; DIPENTYL PHTHALATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHTHALIC ACID DERIVATIVE; SIMVASTATIN; TESTOSTERONE; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; PHTHALIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FETAL WELL BEING; FETUS; FETUS LIVER; FETUS MORTALITY; GENE EXPRESSION; HORMONE TRANSPORT; LITTER SIZE; LIVER HISTOLOGY; LIVER WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; SEX DIFFERENTIATION; SPRAGUE DAWLEY RAT; TESTOSTERONE SYNTHESIS; UNINDEXED SEQUENCE; WEIGHT GAIN; ANIMAL; BIOSYNTHESIS; BLOOD; DOSE RESPONSE; DRUG EFFECTS; FETUS BLOOD; GENE EXPRESSION REGULATION; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; MATERNAL EXPOSURE; METABOLISM; PREGNANCY; TESTIS; TISSUE CULTURE TECHNIQUE;

RATTUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPIDS; MALE; MATERNAL EXPOSURE; PHTHALIC ACIDS; PREGNANCY; RATS, SPRAGUE-DAWLEY; SEX DIFFERENTIATION; SIMVASTATIN; TESTIS; TESTOSTERONE; TISSUE CULTURE TECHNIQUES;

EID: 84911482311     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu149     Document Type: Article

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