Determination of the di-(2-ethylhexyl) phthalate noael for reproductive development in the rat: Importance of the retention of extra animals to adulthood

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 640-646

  Blystone, Chad R ^a   Kissling, Grace E ^a   Bishop, Jack B ^a   Chapin, Robert E ^a,c   Wolfe, Gary W ^b,d   Foster, Paul M D ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b TherImmune Research Corporation   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d Aclairo Pharmaceutical Development Group Inc   (United States)

Author keywords

Dose response; Endocrine disruption; Phthalate; RACB; Reproductive and development; Reproductive tract

Indexed keywords

DI (2 ETHYLHEXYL) PHTHALIC ACID; PHTHALIC ACID DERIVATIVE; UNCLASSIFIED DRUG; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; FEMALE; GENITAL MALFORMATION; GENITAL SYSTEM; MALE; MONTE CARLO METHOD; NONHUMAN; PROSTATE; RAT; SEMINAL VESICLE; TESTIS; ANIMAL; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG SURVEILLANCE PROGRAM; SPRAGUE DAWLEY RAT; TOXICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENITALIA; MALE; MONTE CARLO METHOD; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955084114     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq147     Document Type: Article

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