Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers

Journal of Psychopharmacology

Volumn 28, Issue 12, 2014, Pages 1170-1177

  Fagundo, Ana B ^a   Fernández Aranda, Fernando ^a,b,c   De La Torre, Rafael ^b,d   Verdejo García, Antonio ^e,f,g   Granero, Roser ^b,h   Penelo, Eva ^h   Gené, Manel ^c   Barrot, Carme ^c   Sánchez, Cristina ^a   Alvarez Moya, Eva ^a   Ochoa, Cristian ^b   Aymamí, Maria Neus ^a   Gómez Peña, Mónica ^a   Menchón, Jose M ^a,b,i   Jiménez Murcia, Susana ^a,b,c  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e MONASH UNIVERSITY   (Australia)

^f UNIVERSITY OF GRANADA   (Spain)

^g INSTITUTO DE SALUD CARLOS III   (Spain)

^h UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

ⁱ CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

Addiction; cognition; cognitive flexibility; dopamine; dopamine receptor; dopamine transport; executive functions; gambling; genetics; inhibition response; pathological gambling; polymorphism

Indexed keywords

ANKYRIN; ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 PROTEIN; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; PHOSPHOTRANSFERASE; PROTEIN DAT1; PROTEIN TAQ1A; UNCLASSIFIED DRUG; ANKK1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SLC6A3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HETEROZYGOTE; HIGH RISK PATIENT; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; PATHOLOGICAL GAMBLING; PSYCHOLOGIC TEST; STROOP TEST; VARIABLE NUMBER OF TANDEM REPEAT; WISCONSIN CARD SORTING TEST; ADOLESCENT; COGNITION; GAMBLING; GENETICS; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COGNITION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GAMBLING; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DOPAMINE D2; YOUNG ADULT;

EID: 84911436690     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881114551079     Document Type: Article

References (58)

1. Alvarez-Moya EM, Ochoa C, Jimenez-Murcia S, et al. Effect of executive functioning, decision-making and self-reported impulsivity on the treatment outcome of pathologic gambling. J Psychiatry Neurosci. 2011 ; 36: 165-175
2. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: APA ; 2000 :
3. Bannon MJ, Roth RH. Pharmacology of mesocortical dopamine neurons. Pharmacol Rev. 1983 ; 35: 53-68
4. Bannon MJ, Michelhaugh SK, Wang J, et al. The human dopamine transporter gene: Gene organization, transcriptional regulation and potential involvement in neuropsychiatric disorders. Eur Neuropsychopharmacol. 2001 ; 11: 449-455
5. Bartrés-Faz D, Junqué C, Serra-Grabulosa JM, et al. Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory impaired subjects. Neuroreport. 2002 ; 13: 1121-1125
6. Bolton JL, Marioni RE, Deary IJ, et al. Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl-transferase genes and cognitive function. Behav Genet. 2010 ; 40: 630-638
7. Braet W, Johnson KA, Tobin CT, et al. fMRI activation during response inhibition and error processing: The role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD. Neuropsychologia. 2011 ; 49: 1641-1650
8. Brehmer Y, Westerberg H, Bellander M, et al. Working memory plasticity modulated by dopamine transporter genotype. Neurosci Lett. 2009 ; 467: 117-120
9. Congdon E, Canli T. A neurogenetic approach to impulsivity. J Pers. 2008 ; 76: 1447-1484
10. Cools R, D'Esposito M. Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry. 2011 ; 69 (12). e113-125
11. Cropley VL, Fujita M, Innis RB, et al. Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol Psychiatry. 2006 ; 59: 898-907
12. Eisenberg DT, Campbell B, Mackillop J, et al. Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS One. 2007 ; 2: e1216 - e1225
13. Enoch MA, Goldman D. The genetics of alcoholism and alcohol abuse. Curr Psychiatry Rep. 2001 ; 3: 144-151
14. Floresco SB, Magyar O. Mesocortical dopamine modulation of executive functions: Beyond working memory. Psychopharmacology. 2006 ; 188: 567-585
15. Floresco SB, Magyar O, Ghods-Sharifi S, et al. Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting. Neuropsychopharmacology. 2006 ; 31: 297-309
16. Frank MJ, Fossella JA. Neurogenetics and pharmacology of learning, motivation and cognition. Neuropsychopharmacology. 2011 ; 36: 133-152
17. Gligorovic M, Buha N. Conceptual abilities of children with mild intellectual disability: Analysis of Wisconsin Card Sorting Test performance. J Intellect Dev Disabil. 2013 ; 38: 134-140
18. Golden CJ Stroop Color and Word Test: Manual for Clinical and Experimental Uses. Chicago: Stoeling ; 1978:
19. Gordon EM, Devaney JM, Bean S, et al. Resting-state striato-frontal functional connectivity is sensitive to DAT1 genotype and predicts executive function. Cereb Cortex. 2013 ;:
20. Goudriaan AE, Oosterlaan J, De Beurs E, et al. Neurocognitive functions in pathological gambling: A comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction. 2006 ; 101: 534-547
21. Hack LM, Kalsi G, Aliev F, et al. Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Alcohol Clin Exp Res. 2011 ; 35: 376-385
22. Heaton RK Wisconsin Card Sorting Test manual. Odessa, FL: Psychological Assessment Resources ; 1981:
23. HollingsheadAB (1975) Four-factor Index of Social Status. New Haven, CT: Unpublished manuscript, Yale University, Department of Sociology.
24. Hsieh PC, Yeh TL, Lee IH, et al. Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers. J Psychiatry Neurosci. 2010 ; 35: 90-94
25. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: The role of reward-related learning and memory. Annu Rev Neurosci. 2006 ; 29: 565-598
26. Jocham GT, Klein A, Neumann J, et al. Dopamine DRD2 polymorphism alters reversal learning and associated neural activity. J Neurosci. 2009 ; 29: 3695-3704
27. Joutsa J, Johansson J, Niemelä S, et al. Mesolimbic dopamine release is linked to symptom severity in pathological gambling. Neuroimage. 2012 ; 60: 1992-1999
28. Kemppainen N, Laine M, Laakso MP, et al. Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease. Eur J Neurosci. 2003 ; 18: 149-154
29. Klein TA, Neumann J, Reuter M, et al. Genetically-determined differences in learning from errors. Science. 2007 ; 318: 1642-1645
30. Krugel LK, Biele G, Mohr PN, et al. Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions. Proc Natl Acad Sci USA. 2009 ; 106: 17951-17956
31. Lawrence AJ, Luty J, Bogdan NA, et al. Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals. Addiction. 2009 ; 104: 1006-1015
32. Leber A, Turk-Browne N, Chun M. Neural predictors of moment-to-moment fluctuations in cognitive flexibility. Proc Natl Acad Sci USA. 2008 ; 105: 13592-13597
33. Lesieur HR, Blume SB. The South Oaks Gambling Screen (SOGS): A new instrument for the identification of pathological gamblers. Am J Psychiatry. 1987 ; 144: 1184-1148
34. Loo SK, Specter E, Smolen A, et al. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. J Am Acad Child Adolesc Psychiatry. 2003 ; 42: 986-993
35. Markett S, Montag C, Walter NT, et al. On the molecular genetics of flexibility: The case of task-switching, inhibitory control and genetic variants. Cogn Affect Behav Neurosci. 2011 ; 11: 644-651
36. Mattay VS, Goldberg TE, Fera F, et al. Catechol-O-methyl-transferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Nat Acad Sci USA. 2003 ; 100: 6186-6191
37. Mehta MA, Manes FF, Magnolfi G, et al. Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers. Psychopharmacology. 2004 ; 176: 331-342
38. Meyer G, Schwertfeger J, Exton MS, et al. Neuroendocrine response to casino gambling in problem gamblers. Psychoneuroendocrinology. 2004 ; 29: 1272-1280
39. Mill J, Asherson P, Browes C, et al. Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet. 2002 ; 114: 975-979
40. Moises HW, Frieboes RM, Spelzhaus P, et al. No association between dopamine D2 receptor gene (DRD2) and human intelligence. J Neural Transm. 2001 ; 108: 115-121
41. Montag C, Hartmann P, Merz M, et al. D2 receptor density and prepulse inhibition in humans: Negative findings from a molecular genetic approach. Behav Brain Res. 2008 ; 187: 428-432
42. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: A novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat. 2004 ; 23: 540-545
43. Noble EP. Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: A review. Eur Psychiatry. 2000 ; 15: 79-89
44. Noble EP Am J Med Genet B Neuropsychiatr Genet. 116B: ; 2003: 103-125.
45. Nyhus E, Barceló F. The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: A critical update. Brain Cogn. 2009 ; 71: 437-451
46. Prakash O, Avasthi A, Benegal V. Should pathological gambling be considered an addictive disorder?. Asian J Psychiatr. 2012 ; 5: 211-214
47. Reitan RM. The validity of the Trail-Making Test as an indicator of organic brain damage. Percept Motor Skills. 1958 ; 8: 271-276
48. Reuter M, Peters K, Schroeter K, et al. The influence of the dopaminergic system on cognitive functioning: A molecular genetic approach. Behav Brain Res. 2005 ; 164: 93-99
49. Ritchie T, Noble EP. Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res. 2003 ; 28: 73-82
50. Savitz J, Solms M, Ramesar R. The molecular genetics of cognition: Dopamine, COMT and BDNF. Genes Brain Behav. 2006 ; 5: 311-328
51. Simon JR, Stollstorff M, Westbay LC, et al. Dopamine transporter genotype predicts implicit sequence learning. Behav Brain Res. 2011 ; 216: 452-457
52. Stelzel C, Basten U, Montag C, et al. Frontostriatal involvement in task switching depends on genetic differences in d2 receptor density. J Neurosci. 2010 ; 30: 14205-14212
53. Stuss DT, Alexander MP. Executive functions and the frontal lobes: A conceptual view. Psychol Res. 2000 ; 63: 289-298
54. Tsai SJ, Yu YW, Lin CH, et al. Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit: genetic variants and intelligence. Neuropsychobiology. 2002 ; 45: 128-130
55. Wechsler D Wechsler Adult Intelligence Scale: Third edition administration and scoring manual. San Antonio, TX: Psychological Corporation ; 1997:
56. White MJ, Morris CP, Lawford BR, et al. Behavioral phenotypes of impulsivity related to the ANKK1 gene are independent of an acute stressor. Behav Brain Funct. 2008 ; 4: 54-62
57. Wohl M, Boni C, Asch M, et al. Lack of association of the dopamine transporter gene in a French ADHD sample. Am J Med Genet B Neuropsychiatr Genet. 2008 ; 147: 1509-1510
58. Zack M, Poulos CX. Parallel roles for dopamine in pathological gambling and psychostimulant addiction. Curr Drug Abuse Rev. 2009 ; 2: 11-25