Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival

Human Molecular Genetics

Volumn 23, Issue 21, 2014, Pages 5649-5658

  Chuang, Chia Lung ^a   Lu, Yu Ning ^a   Wang, Hung Cheng ^a   Chang, Hui Yun ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEAD INVOLUTION DEFECTIVE PROTEIN; LEUCINE RICH REPEAT KINASE 2; PROTEIN; PROTEIN GRIM; PROTEIN KINASE B; PROTEIN REAPER; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; LRRK2 PROTEIN, DROSOPHILA; LRRK2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL SURVIVAL; COMPARATIVE STUDY; COMPOUND EYE; CONTROLLED STUDY; DEPHOSPHORYLATION; DOPAMINERGIC NERVE CELL; DROSOPHILA; ENZYME PHOSPHORYLATION; GENE INTERACTION; GENETIC PROCEDURES; INTRACELLULAR SIGNALING; MICRODISSECTION; MOLECULAR WEIGHT; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; WESTERN BLOTTING; WILD TYPE; ALLELE; ANIMAL; BIOLOGICAL MODEL; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; APOPTOSIS; CELL SURVIVAL; DROSOPHILA; DROSOPHILA PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEURONS; PHENOTYPE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84911432623     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu281     Document Type: Article

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