PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

Cell Death and Differentiation

Volumn 20, Issue 7, 2013, Pages 920-930

  Arena, G ^a,b   Gelmetti, V ^a   Torosantucci, L ^a   Vignone, D ^a   Lamorte, G ^a   De Rosa, P ^a,b   Cilia, E ^a   Jonas, E A ^c   Valente, E M ^a,d  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SALERNO   (Italy)

Author keywords

Apoptosis; Mitochondria; Parkinson's disease; Post translational modifications

Indexed keywords

BECLIN 1; PINK 1 PROTEIN; PROTEIN; PROTEIN BCL XL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPOLARIZATION; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOPRECIPITATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BCL-X PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 84880303306     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.19     Document Type: Article

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