Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI

NMR in Biomedicine

Volumn 27, Issue 12, 2014, Pages 1490-1501

  Qing, Kun ^a   Mugler, John P ^a,b   Altes, Talissa A ^a   Jiang, Yun ^c   Mata, Jaime F ^a   Miller, G Wilson ^a   Ruset, Iulian C ^d,e   Hersman, F William ^d,e   Ruppert, Kai ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b University of Virginia   (United States)

^c Case Western Reserve University   (United States)

^d Xemed LLC   (United States)

^e Univ of New Hampshire   (United States)

Author keywords

3D dissolved phase imaging; Asthma; COPD; CSSR; Gas uptake; Hyperpolarized xenon 129; Pulmonary imaging

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; CARBON MONOXIDE; CHEMICAL SHIFT; DISEASES; DISSOLUTION; GASES; MAGNETIC RESONANCE; MERGERS AND ACQUISITIONS; PULMONARY DISEASES; TISSUE;

ASTHMA; COPD; CSSR; GAS UPTAKE; HYPERPOLARIZED XENON-129; PHASE IMAGING; PULMONARY IMAGING;

XENON;

CARBON MONOXIDE; XENON;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHEMICAL SHIFT SATURATION RECOVERY XENON 129 SPECTROSCOPY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISSOLVED PHASE NUCLEAR MAGNETIC RESONANCE IMAGING; FEMALE; HUMAN; IMAGE RECONSTRUCTION; LUNG ALVEOLUS; LUNG DIFFUSION CAPACITY; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG INFLATION; MALE; MEDICAL PARAMETERS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RED BLOOD CELL TO TISSUE PLASMA RATIO; SIMULATION; THICKNESS; COMPUTER SIMULATION; ERYTHROCYTE; LUNG; LUNG VENTILATION; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SPECTROSCOPY; THREE DIMENSIONAL IMAGING; YOUNG ADULT;

ADOLESCENT; ADULT; ASTHMA; CARBON MONOXIDE; COMPUTER SIMULATION; ERYTHROCYTES; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; LUNG; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; SPECTRUM ANALYSIS; XENON ISOTOPES; YOUNG ADULT;

EID: 84911427250     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.3179     Document Type: Article

References (45)

1. Salerno M, Altes TA, Mugler JP 3rd, Nakatsu M, Hatabu H, de Lange EE. Hyperpolarized noble gas MR imaging of the lung: potential clinical applications. Eur. J. Radiol. 2001; 40(1): 33-44.
2. van Beek EJ, Wild JM, Kauczor HU, Schreiber W, Mugler JP 3rd, de Lange EE. Functional MRI of the lung using hyperpolarized 3-helium gas. J. Magn. Reson. Imaging 2004; 20(4): 540-554.
3. Fain S, Schiebler ML, McCormack DG, Parraga G. Imaging of lung function using hyperpolarized helium-3 magnetic resonance imaging: review of current and emerging translational methods and applications. J. Magn. Reson. Imaging 2010; 32(6): 1398-1408.
4. 129Xe MRI of the human lung. J. Magn. Reson. Imaging 2013; 37(2): 313-331.
5. 129Xe for human lung imaging studies. Acad. Radiol. 2008; 15(6): 683-692.
6. Abraham MH, Kamlet MJ, Taft RW, Doherty RM, Weathersby PK. Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids. J. Med. Chem. 1985; 28(7): 865-870.
7. Miller KW, Reo NV, Schoot Uiterkamp AJ, Stengle DP, Stengle TR, Williamson KL. Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes. Proc. Natl. Acad. Sci. U. S. A. 1981; 78(8): 4946-4949.
8. 129Xe gas: preliminary human results. Magn. Reson. Med. 1997; 37(6): 809-815.
9. 129Xe resonances in living rats. J. Magn. Reson. B 1996; 111(3): 300-304.
10. Ruppert K, Brookeman JR, Hagspiel KD, Driehuys B, Mugler JP 3rd. NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. NMR Biomed. 2000; 13(4): 220-228.
11. 129Xe. Magn. Reson. Med. 1996; 36(2): 183-191.
12. Butler JP, Mair RW, Hoffmann D, Hrovat MI, Rogers RA, Topulos GP, Walsworth RL, Patz S. Measuring surface-area-to-volume ratios in soft porous materials using laser-polarized xenon interphase exchange nuclear magnetic resonance. J. Phys. Condens. Matter 2002; 14(13): L297-304.
13. 129Xe MRI. Proc. Natl. Acad. Sci. U. S. A. 2006; 103(48): 18278-18283.
14. Dregely I, Mugler JP 3rd, Ruset IC, Altes TA, Mata JF, Miller GW, Ketel J, Ketel S, Distelbrink J, Hersman FW, Ruppert K. Hyperpolarized xenon-129 gas-exchange imaging of lung microstructure: first case studies in subjects with obstructive lung disease. J. Magn. Reson. Imaging 2011; 33(5): 1052-1062.
15. 129Xe. Magn. Reson. Med. 2003; 50(6): 1170-1179.
16. Cleveland ZI, Moller HE, Hedlund LW, Nouls JC, Freeman MS, Qi Y, Driehuys B. In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe. PLoS ONE 2012; 7(2): e31306.
17. 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn. Reson. Med. 2006; 56(2): 255-264.
18. 129Xe at 0.2T. Acad. Radiol. 2008; 15(6): 713-727.
19. Ruppert K, Mata JF, Brookeman JR, Hagspiel KD, Mugler JP 3rd. Exploring lung function with hyperpolarized (129)Xe nuclear magnetic resonance. Magn. Reson. Med. 2004; 51(4): 676-687.
20. 129Xe septal uptake and experimental results. New J. Phys. 2011; 13(1): 015009.
21. Chang YV. Toward a quantitative understanding of gas exchange in the lung. arXiv: 10083961v1 2010.
22. 129Xe magnetic resonance of the lung. Magn. Reson. Med. 2013; 69(3): 884-890.
23. Cleveland ZI, Cofer GP, Metz G, Beaver D, Nouls J, Kaushik SS, Kraft M, Wolber J, Kelly KT, McAdams HP, Driehuys B. Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. PLoS ONE 2010; 5(8): e12192.
24. Mugler JP 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW, Ketel S, Ketel J, Hersman FW, Ruppert K. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc. Natl. Acad. Sci. U. S. A. 2010; 107(50): 21707-21712.
25. 129Xe MR imaging. J. Appl. Physiol.. 2013; 115(6): 850-860.
26. 129Xe alveolar gas uptake in a mouse model of emphysema. Magn. Reson. Med. 2013; 70(1): 207-215.
27. Chang YV, Quirk JD, Ruset IC, Atkinson JJ, Hersman FW, Woods JC. Quantification of human lung structure and physiology using hyperpolarized Xe. Magn. Reson. Med. 2014; 71(1): 339-344.
28. Ruppert K, Mata JF, Dregely I, Altes TA, Miller GW, Ketel S, Ketel J, Ruset IC, Hersman FW, Mugler JP 3rd. Hyperpolarized xenon-129 dissolved-phase signal dependence on the echo time (abstract). Proc. ISMRM, Stockholm, Sweden, 2010; 2552.
29. Qing K, Ruppert K, Jiang Y, Mata JF, Miller GW, Shim YM, Wang C, Ruset IC, Hersman FW, Altes TA, Mugler JP 3rd. Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI. J. Magn. Reson. Imaging 2014; 39(2): 346-359.
30. Tsao J, Jiang Y. Hierarchical IDEAL: fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. Magn. Reson. Med. 2013; 70(1): 155-159.
31. 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease. Acad. Radiol. 2012; 19(8): 941-951.
32. Driehuys B, Martinez-Jimenez S, Cleveland ZI, Metz GM, Beaver DM, Nouls JC, Kaushik SS, Firszt R, Willis C, Kelly KT, Wolber J, Kraft M, McAdams HP. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology 2012; 262(1): 279-289.
33. Driehuys B, Cates GD, Miron E, Sauer K, Walter DK, Happer W. High-volume production of laser-polarized 129Xe. Appl. Phys. Lett. 1996; 69(12): 1668.
34. Ruppert K, Altes TA, Mata JF, Ruset IC, Hersman FW, Mugler JP 3rd. Detecting pulmonary capillary blood pulsations using hyperpolarized 129Xe CSSR (abstract). Proc. ISMRM, Salt Lake City, USA, 2013; 817.
35. Matson GB. An integrated program for amplitude-modulated RF pulse generation and re-mapping with shaped gradients. Magn. Reson. Imaging 1994; 12(8): 1205-1225.
36. Mugler JP 3rd, Altes TA, Ruset IC, Miller GW, Mata JF, Qing K, Tsentalovich I, Hersman FW, Ruppert K. Image-based measurement of T2* for dissolved-phase Xe129 in the human lung (abstract). Proc. ISMRM, Melbourne, Australia, 2012; 1347.
37. Chan RW, Ramsay EA, Cheung EY, Plewes DB. The influence of radial undersampling schemes on compressed sensing reconstruction in breast MRI. Magn. Reson. Med. 2012; 67(2): 363-377.
38. Sutton BP, Noll DC, Fessler JA. Fast, iterative image reconstruction for MRI in the presence of field inhomogeneities. IEEE Trans. Med. Imaging 2003; 22(2): 178-188.
39. Ruppert K, Altes TA, Mata JF, Ruset IC, Hersman FW, Mugler JP 3rd. Measuring septal wall thickness in human lung disease using Xe129 CSSR spectroscopy (abstract). In: ISMRM 21st Annual Meeting and Exhibition, 20-26 April 2013, Salt Lake City, Utah, USA. p. 1455.
40. Vlahovic G, Russell ML, Mercer RR, Crapo JD. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am. J. Respir. Crit. Care Med. 1999; 160(6): 2086-2092.
41. Estepar RS, Kinney GL, Black-Shinn JL, Bowler RP, Kindlmann GL, Ross JC, Kikinis R, Han MK, Come CE, Diaz AA, Cho MH, Hersh CP, Schroeder JD, Reilly JJ, Lynch DA, Crapo JD, Wells JM, Dransfield MT, Hokanson JE, Washko GR, Study CO. Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am. J. Respir. Crit. Care Med. 2013; 188(2): 231-239.
42. Meyer N, Akdis CA. Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways. Curr. Allergy Asthma Rep. 2013; 13(1): 1-9.
43. Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax 2009; 64(8): 728-735.
44. Dregely I, Ruset IC, Mata JF, Ketel J, Ketel S, Distelbrink J, Altes TA, Mugler JP 3rd, Wilson Miller G, William Hersman F, Ruppert K. Multiple-exchange-time xenon polarization transfer contrast (MXTC) MRI: initial results in animals and healthy volunteers. Magn. Reson. Med. 2012; 67(4): 943-953.
45. An L, Warach S, Shen J. Spectral localization by imaging using multielement receiver coils. Magn. Reson. Med. 2011; 66(1): 1-10.