Large Production System for Hyperpolarized 129Xe for Human Lung Imaging Studies

Academic Radiology

Volumn 15, Issue 6, 2008, Pages 683-692

  Hersman, F William ^a,b   Ruset, Iulian C ^a,b   Ketel, Stephen ^a   Muradian, Iga ^c   Covrig, Silviu D ^a   Distelbrink, Jan ^b   Porter, Walter ^b   Watt, David ^b   Ketel, Jeffrey ^b   Brackett, John ^b   Hope, Aaron ^b   Patz, Samuel ^c  

^a Univ of New Hampshire   (United States)

^b Xemed LLC   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

129 Xe; 129Xe; Hyperpolarized xenon; laser polarized noble gas; lung imaging; Xe 129

Indexed keywords

RADIOISOTOPE; RUBIDIUM; XENON 129;

ARTICLE; FREEZE THAWING; GAS; GAS FLOW; LASER; LUNG; NUCLEAR MAGNETIC RESONANCE IMAGING; POLARIZATION; PRIORITY JOURNAL;

EQUIPMENT DESIGN; HUMANS; LASERS; LUNG DISEASES; MAGNETIC RESONANCE IMAGING; OPTICS; XENON ISOTOPES;

EID: 43249093673     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2007.09.020     Document Type: Article

References (29)

1. 3 gas induced by optical pumping in dipolar exchange. Phys Rev Lett 5 (1960) 373-375
2. 3 gas by optical pumping. Phys Rev 132 (1963) 2561-2572
3. 129Xe. Nature (London) 370 (1994) 199-201
4. Wagshul M.E., and Chupp T.E. Laser optical pumping of high-density Rb in polarized 3he targets. Phys Rev A 49 (1994) 3854-3869
5. 3He target based on compression of optically pumped gas. Nucl Instrum Methods Phys Res A 320 (1992) 53-65
6. Rich D.R., Gentile T.R., Smith T.B., et al. Spin exchange optical pumping at pressures near 1 bar for neutron spin filters. Appl Phys Lett 80 (2002) 2210-2212
7. 3He at coated glass walls. Part II. Eur Phys J D 38 (2006) 439-443
8. van Beek E.J.R., Schmiedeskamp J., Wild J.M., et al. Hyperpolarized 3-helium MR imaging of the lungs: testing the concept of a central production facility. Eur Radiol 13 (2003) 2583-2586
9. Gast K.K., Eberle B., Schmiedeskamp J., et al. Magnetic resonance imaging using hyperpolarized 3He-Gas. Acad Radiol 10 (2003) 1119-1131
10. Fischer M.C., Kadlecek S., Yu J., et al. Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI. Acad Radiol 12 (2005) 1430-1439
11. Conradi M.S., Yablonskiy D.A., Woods J.C., et al. 3He diffusion MRI of the lung. Acad Radiol 12 (2005) 1406-1413
12. Albert M.S., and Balamore D. Development of hyperpolarized noble gas MRI. Nucl Instrum Methods Phys Res A 402 (1998) 441-453
13. Goto T., Suwa K., Uezono S., et al. The blood-gas partition coefficient of xenon may be lower than generally accepted. Br J Anaesth 80 (1998) 255-256
14. Raftery D., Long H., Meersmann T., et al. High-field NMR of adsorbed xenon polarized by laser pumping. Phys Rev Lett 66 (1991) 584-587
15. 129Xe in NMR spectroscopy. Adv Mat 7 (1995) 826-838
16. Wagshul M.E., Button T.M., Haifang F.L., et al. In vivo MR imaging and spectroscopy using hyperpolarized 129xe. Magn Reson Med 36 (1996) 183-191
17. Bifone A., Song Y.Q., Seydoux R., et al. NMR of laser-polarized xenon in human blood. Proc Natl Acad Sci U S A 93 (1996) 12932-12936
18. Butler J.P., Mair R.W., Hoffmann D., et al. Measuring surface-area-to-volume ratios in soft porous materials using laser-polarized xenon interphase exchange nuclear magnetic resonance. J Phys Condens Matter 14 (2002) L297-L304
19. Ruppert K., Mata J.F., Brookeman J.R., et al. Exploring lung function with hyperpolarized (129)Xe nuclear magnetic resonance. Magn Reson Med 51 (2004) 676-687
20. Sanders R.D., Ma D., and Maze M. Xenon: elemental anaesthesia in clinical practice. Br Med Bull 71 (2004) 115-135
21. Happer W. Optical pumping. Rev Mod Phys 44 (1972) 169-250
22. Romalis M.V., Miron E., and Cates G.D. Pressure broadening of RB D1 and D2 lines by 3He, 4He, N2, and XE: line cores and near wings. Phys Rev A 56 (1997) 4569-4578
23. 129Xe gas. Appl Phys B 68 (1999) 93-97
24. Chann B., Babcock E., Anderson L.W., et al. Skew light propagation in optically thick optical pumping cells. Phys Rev A 66 (2002) 033406
25. Kuzma N.N., Patton N., Raman K., et al. Fast nuclear spin relaxation in hyperpolarized solid 129-xenon. Phys Rev Lett 88 (2002) 147602
26. Ruset I.C., Ketel S., and Hersman F.W. Optical pumping system design for large production of hyperpolarized 129xe. Phys Rev Lett 96 (2006) 053002
27. Patton B., Kuzma N.N., and Happer W. Reducing the relaxation of frozen hyperpolarized 129xe during cryogenic separation. Proc 35th DAMOP (2004) C4.011
28. 129Xe MRI: A viable functional lung imaging modality?. Eur J Radiol (2007) In press
29. Zhu H., Ruset I.C., and Hersman F.W. Spectrally narrowed external-cavity high-power stack of laser diode arrays. Opt Lett 30 (2005) 1342-1344