Chronic obstructive pulmonary disease: Safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients

Radiology

Volumn 262, Issue 1, 2012, Pages 279-289

  Driehuys, Bastiaan ^a   Martinez Jimenez, Santiago ^a   Cleveland, Zackary I ^a   Metz, Gregory M ^a   Beaver, Denise M ^a   Nouls, John C ^a   Kaushik, S Sivaram ^a,b   Firszt, Rafael ^a   Willis, Christine ^a   Kelly, Kevin T ^c   Wolber, Jan ^d   Kraft, Monica ^a   McAdams, H Page ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Duke University   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GE HEALTHCARE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; XENON; XENON 129;

ABNORMAL SENSATION; ADULT; AMNESIA; APPLICATION SITE REACTION; ARTICLE; BLOOD PRESSURE; BLURRED VISION; BREATH HOLDING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DRUG INDUCED DISEASE; DRUG INDUCED HEADACHE; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; DYSARTHRIA; DYSGEUSIA; ELECTROCARDIOGRAM; EUPHORIA; FACIAL HYPESTHESIA; FEMALE; FLUSHING; GASTROINTESTINAL DISEASE; HEART RATE; HUMAN; HYPERHIDROSIS; HYPERPOLARIZATION; HYPERTENSION; HYPESTHESIA; HYPOACUSIS; IMAGE ANALYSIS; IMAGE QUALITY; MALE; MENTAL DISEASE; ORAL HYPOESTHESIA; ORAL PARESTHESIA; OXYGEN SATURATION; PARESTHESIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SIDE EFFECT; SKIN DISEASE; SOMNOLENCE; SYSTOLIC BLOOD PRESSURE; TONGUE DISEASE; VISUAL BRIGHTNESS; VISUAL DISORDER; XEROSTOMIA;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; XENON ISOTOPES;

EID: 84455200725     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.11102172     Document Type: Article

References (31)

1. 129Xe. Nature 1994;370(6486):199-201.
2. Mugler JP 3rd, Driehuys B, Brookeman JR, et al. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med 1997;37(6):809-815. (Pubitemid 27270755)
3. Möller HE, Chen XJ, Saam B, et al. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 2002;47(6):1029-1051. (Pubitemid 34587394)
4. Ebert M, Grossmann T, Heil W, et al. Nuclear magnetic resonance imaging with hyperpolarised helium-3. Lancet 1996;347(9011):1297-1299. (Pubitemid 26137794)
5. MacFall JR, Charles HC, Black RD, et al. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology 1996;200(2):553-558.
6. 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. Eur Respir J 2009;34(6):1311-1321.
7. Fain SB, Panth SR, Evans MD, et al. Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging. Radiology 2006;239(3):875-883. (Pubitemid 43830626)
8. 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol 1999;173(4):955-959.
9. Mentore K, Froh DK, de Lange EE, Brookeman JR, Paget-Brown AO, Altes TA. Hyperpolarized HHe 3 MRI of the lung in cystic fibrosis: assessment at baseline and after bronchodilator and airway clearance treatment. Acad Radiol 2005;12(11):1423-1429. (Pubitemid 41512835)
10. Salerno M, de Lange EE, Altes TA, Truwit JD, Brookeman JR, Mugler JP 3rd. Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes - initial experience. Radiology 2002;222(1):252-260. (Pubitemid 34031496)
11. 3He MR imaging. Radiology 2010;256(1):280-289.
12. 3He diffusion MRI. J Appl Physiol 2009;107(4):1258-1265.
13. 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects. Radiology 2008;248(2):655-661.
14. Kramer D. DOE begins rationing helium-3. Physics Today June 10, 2010:22-25.
15. 129Xe MR imaging of alveolar gas uptake in humans. PLoS One 2010;5(8):e12192.
16. Mugler JP 3rd, Altes TA, Ruset IC, et al. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A 2010;107(50):21707-21712.
17. 129Xe. Phys Rev Lett 2006;96(5):053002.
18. Patz S, Hersman FW, Muradian I, et al. Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality? Eur J Radiol 2007;64(3):335-344. (Pubitemid 350116490)
19. Patz S, Muradian I, Hrovat MI, et al. Human pulmonary imaging and spectroscopy with hyperpolarized 129Xe at 0.2T. Acad Radiol 2008;15(6):713-727. (Pubitemid 351657712)
20. Kennedy RR, Stokes JW, Downing P. Anaesthesia and the 'inert' gases with special reference to xenon. Anaesth Intensive Care 1992;20(1):66-70.
21. Latchaw RE, Yonas H, Pentheny SL, Gur D. Adverse reactions to xenon-enhanced CT cerebral blood flow determination. Radiology 1987;163(1):251-254. (Pubitemid 17043037)
22. 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011;65(4):1154-1165.
23. 129Xe. Appl Phys Lett 1996;69(12):1668-1670.
24. Drazen JM, Loring SH, Ingram RH Jr. Distribution of pulmonary resistance: effects of gas density, viscosity, and flow rate. J Appl Physiol 1976;41(3):388-395.
25. Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, Grist TM. Functional lung imaging using hyperpolarized gas MRI. J Magn Reson Imaging 2007;25(5):910-923. (Pubitemid 46697560)
26. Liu MB, Davis K. A clinical trials manual from the Duke Clinical Research Institute: lessons from a horse named Jim. Oxford, England: Wiley, 2010.
27. Højgaard MV, Holstein-Rathlou NH, Agner E, Kanters JK. Reproducibility of heart rate variability, blood pressure variability and baroreceptor sensitivity during rest and head-up tilt. Blood Press Monit 2005;10(1):19-24. (Pubitemid 40316148)
28. 129Xe in oxygen. J Chem Phys 1988;89(7):4074-4081.
29. Liotti M, Martin CC, Gao JH, et al. Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography: implications for hyperpolarized xenon MRI. J Magn Reson Imaging 1997;7(4):761-764. (Pubitemid 28365628)
30. Kilian W, Seifert F, Rinneberg H. Dynamic NMR spectroscopy of hyperpolarized (129) Xe in human brain analyzed by an uptake model. Magn Reson Med 2004;51(4):843-847. (Pubitemid 38420463)
31. Susskind H, Atkins HL, Cohn SH, Ellis KJ, Richards P. Whole-body retention of radioxenon. J Nucl Med 1977;18(5):462-471.