Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI

Journal of Magnetic Resonance Imaging

Volumn 39, Issue 2, 2014, Pages 346-359

  Qing, Kun ^a   Ruppert, Kai ^a   Jiang, Yun ^b   Mata, Jaime F ^a   Miller, G Wilson ^a   Shim, Y Michael ^a   Wang, Chengbo ^a   Ruset, Iulian C ^c,d   Hersman, F William ^c,d   Altes, Talissa A ^a   Mugler, John P ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Case Western Reserve University   (United States)

^c Xemed LLC   (United States)

^d Univ of New Hampshire   (United States)

Author keywords

gas uptake; hyperpolarized xenon 129; lung imaging; pulmonary disease

Indexed keywords

UNCLASSIFIED DRUG; XENON; XENON 129;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE PROCESSING; IMAGING SYSTEM; LUNG PARENCHYMA; MALE; MEDICAL DEVICE; MIDDLE AGED; MONITOR; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; SMOKING; SPIROMETRY; YOUNG ADULT;

GAS UPTAKE; HYPERPOLARIZED XENON-129; LUNG IMAGING; PULMONARY DISEASE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; CONTRAST MEDIA; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; LUNG; LUNG DISEASES; MAGNETIC RESONANCE IMAGING; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PULMONARY GAS EXCHANGE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; XENON ISOTOPES; YOUNG ADULT;

EID: 84892806625     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24181     Document Type: Article

References (45)

1. Salerno M, Altes TA, Mugler JP III, Nakatsu M, Hatabu H, de Lange EE,. Hyperpolarized noble gas MR imaging of the lung: potential clinical applications. Eur J Radiol 2001; 40: 33-44.
2. Moller HE, Chen XJ, Saam B, et al. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 2002; 47: 1029-1051.
3. van Beek EJ, Wild JM, Kauczor HU, Schreiber W, Mugler JP III, de Lange EE,. Functional MRI of the lung using hyperpolarized 3-helium gas. J Magn Reson Imaging 2004; 20: 540-554.
4. Matsuoka S, Patz S, Albert MS, et al. Hyperpolarized gas MR imaging of the lung: current status as a research tool. J Thorac Imaging 2009; 24: 181-188.
5. Fain S, Schiebler ML, McCormack DG, Parraga G,. Imaging of lung function using hyperpolarized helium-3 magnetic resonance imaging: review of current and emerging translational methods and applications. J Magn Reson Imaging 2010; 32: 1398-1408.
6. Abraham MH, Kamlet MJ, Taft RW, Doherty RM, Weathersby PK,. Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids. J Med Chem 1985; 28: 865-870.
7. Miller KW, Reo NV, Schoot Uiterkamp AJ, Stengle DP, Stengle TR, Williamson KL,. Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes. Proc Natl Acad Sci U S A 1981; 78: 4946-4949.
8. Sakai K, Bilek AM, Oteiza E, et al. Temporal dynamics of hyperpolarized 129Xe resonances in living rats. J Magn Reson B 1996; 111: 300-304.
9. Ruppert K, Brookeman JR, Hagspiel KD, Mugler JP III,. Probing lung physiology with xenon polarization transfer contrast (XTC). Magn Reson Med 2000; 44: 349-357.
10. Butler JP, Mair RW, Hoffmann D, et al. Measuring surface-area-to-volume ratios in soft porous materials using laser-polarized xenon interphase exchange nuclear magnetic resonance. J Phys Condens Matter 2002; 14: L297-304.
11. Mansson S, Wolber J, Driehuys B, Wollmer P, Golman K,. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med 2003; 50: 1170-1179.
12. Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA,. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A 2006; 103: 18278-18283.
13. Abdeen N, Cross A, Cron G, et al. Measurement of xenon diffusing capacity in the rat lung by hyperpolarized 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn Reson Med 2006; 56: 255-264.
14. Patz S, Hersman FW, Muradian I, et al. Hyperpolarized 129Xe MRI: a viable functional lung imaging modality? Eur J Radiol 2007; 64: 335-344.
15. Wagshul ME, Button TM, Li HF, et al. In vivo MR imaging and spectroscopy using hyperpolarized 129Xe. Magn Reson Med 1996; 36: 183-191.
16. Mugler JP III, Driehuys B, Brookeman JR, et al. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med 1997; 37: 809-815.
17. Ruppert K, Brookeman JR, Hagspiel KD, Driehuys B, Mugler JP III,. NMR of hyperpolarized 129Xe in the canine chest: spectral dynamics during a breath-hold. NMR Biomed 2000; 13: 220-228.
18. Dregely I, Mugler JP III, Ruset IC, et al. Hyperpolarized xenon-129 gas-exchange imaging of lung microstructure: first case studies in subjects with obstructive lung disease. J Mag Reson Imaging 2011; 33: 1052-1062.
19. Swanson SD, Rosen MS, Coulter KP, Welsh RC, Chupp TE,. Distribution and dynamics of laser-polarized 129Xe magnetization in vivo. Magn Reson Med 1999; 42: 1137-1145.
20. Wakayama T, Narazaki M, Kimura A, Fujiwara H,. Hyperpolarized 129Xe phase-selective imaging of mouse lung at 9.4T using a continuous-flow hyperpolarizing system. Magn Reson Med Sci 2008; 7: 65-72.
21. Muradian I, Patz S, Butler JP, et al. Hyperpolarized 129Xe human pulmonary gas exchange with 3-point Dixon technique (abstract). In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, Washington, 2006. (abstract 1297).
22. Hersman FW, Ruset IC, Ketel S, et al. Large production system for hyperpolarized 129Xe for human lung imaging studies. Acad Radiol 2008; 15: 683-692.
23. Cleveland ZI, Cofer GP, Metz G, et al. Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. PLoS ONE 2010; 5: e12192.
24. Mugler JP III, Altes TA, Ruset IC, et al. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A 2010; 107: 21707-21712.
25. Mugler JP III, Altes TA, Ruset IC, et al. Image-based measurement of T2* for dissolved-phase Xe129 in the human lung (abstract). In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Austrailia, 2012. (abstract 1347).
26. Kaushik SS, Cofer GP, Freeman MS, Cleveland ZI, Driehuys B,. Single-acquisition imaging of hyperpolarized 129Xe in the gas and dissolved phases using an interleaved 3D-radial sequence (abstract). In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Canada, 2011. (abstract 878).
27. Matson GB,. An integrated program for amplitude-modulated RF pulse generation and re-mapping with shaped gradients. Magn Reson Imaging 1994; 12: 1205-1225.
28. Ruppert K, Mata JF, Dregely IM, et al. Hyperpolarized xenon-129 dissolved-phase signal dependence on the echo time (abstract). In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden, 2010. (abstract 2552).
29. Dixon WT,. Simple proton spectroscopic imaging. Radiology 1984; 153: 189-194.
30. Glover GH, Schneider E,. Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction. Magn Reson Med 1991; 18: 371-383.
31. Reeder SB, McKenzie CA, Pineda AR, et al. Water-fat separation with IDEAL gradient-echo imaging. J Magn Reson Imaging 2007; 25: 644-652.
32. Yu H, McKenzie CA, Shimakawa A, at al. Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation. J Magn Reson Imaging 2007; 26: 1153-1161.
33. Chan RW, Ramsay EA, Cheung EY, Plewes DB,. The influence of radial undersampling schemes on compressed sensing reconstruction in breast MRI. Magn Reson Med 2012; 67: 363-377.
34. Sutton BP, Noll DC, Fessler JA,. Fast, iterative image reconstruction for MRI in the presence of field inhomogeneities. IEEE Trans Med Imaging 2003; 22: 178-188.
35. Tsao J, Jiang Y,. Hierarchical IDEAL-robust water-fat separation at high field by multiresolution field map estimation (abstract). In: Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008. (abstract 653).
36. Jiang Y, Griswold M, Tsao J,. Fast and robust separation of multiple chemical species from arbitrary echo times with complete immunity to phase wrapping. In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Austrailia, 2012. (abstract 2484).
37. Tsao J, Jiang Y,. Hierarchical IDEAL: fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. Magn Reson Med 2012. doi: 10.1002/mrm.24441 [Epub ahead of print].
38. Driehuys B, Cates GD, Miron E, Sauer K, Walter DK, Happer W,. High-volume production of laser-polarized 129Xe. Appl Phys Lett 1996; 69: 1668-1670.
39. Kaushik SS, Cleveland ZI, Cofer GP, et al. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011; 65: 1154-1165.
40. Reis S, Ruppert K, Altes T, et al. Hyperpolarized Xe-129 CSI of the human lung: preliminary results from healthy, second-hand smoker and cystic-fibrosis subjects (abstract). In: Proceedings of the 20th Annual Meeting of ISMRM. Melbourne, Austrailia, 2012. (abstract 629).
41. Ruppert K, Mata JF, Dregely IM, et al. Hyperpolarized xenon-129 dissolved-phase signal dependence on flip angle and TR (abstract). In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden, 2010. (abstract 2551).
42. Ruppert K, Mata JF, Brookeman JR, Hagspiel KD, Mugler JP III,. Exploring lung function with hyperpolarized 129Xe nuclear magnetic resonance. Magn Reson Med 2004; 51: 676-687.
43. Patz S, Muradyan I, Hrovat MI, et al. Diffusion of hyperpolarized 129Xe in the lung: a simplified model of 129Xe septal uptake and experimental results. New J Phys 2011; 13: 015009.
44. Chang YV,. MOXE: a model of gas exchange for hyperpolarized 129Xe magnetic resonance of the lung. Magn Reson Med 2013; 69: 884-890.
45. Vlahovic G, Russell ML, Mercer RR, Crapo JD,. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Resp Crit Care Med 1999; 160: 2086-2092.