Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

Biotechnology and Bioengineering

Volumn 112, Issue 1, 2015, Pages 84-97

  Tescione, Lia ^a   Lambropoulos, James ^a   Paranandi, Madhava Ram ^a   Makagiansar, Helena ^a   Ryll, Thomas ^a  

^a BIOGEN   (United States)

Author keywords

Bioreactor design; Multivariate analysis; Process characterization; Quality by design; Scale down model; Scale up

Indexed keywords

BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELLS; CYTOLOGY; DESIGN; MANUFACTURE; MASS TRANSFER; OXYGEN; QUALITY CONTROL; RECOMBINANT PROTEINS; VOLUMETRIC ANALYSIS;

BIOREACTOR DESIGN; MULTI VARIATE ANALYSIS; PROCESS CHARACTERIZATION; QUALITY BY DESIGNS; SCALE DOWN MODEL; SCALE-UP;

MULTIVARIANT ANALYSIS;

OXYGEN; RECOMBINANT PROTEIN;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BIOREACTOR DESIGN; CELL CULTURE; CELL DENSITY; CHO CELL LINE; LARGE SCALE PRODUCTION; MULTIVARIATE ANALYSIS; NONHUMAN; PROCESS MODEL; PRODUCT DEVELOPMENT; SCALE UP; ANIMAL; BIOLOGICAL MODEL; BIOREACTOR; CRICETULUS; CULTURE TECHNIQUE; DEVICES; HAMSTER; HUMAN; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; OXYGEN; PRINCIPAL COMPONENT ANALYSIS; RECOMBINANT PROTEINS;

EID: 84911408436     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25330     Document Type: Article

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