Scaling down of biopharmaceutical unit operations - Part I: Fermentation

BioPharm International

Volumn 18, Issue 3, 2005, Pages 60-68

  Rathore, Anurag ^a,c   Krishnan, Raj ^a   Tozer, Stephanie ^a   Smiley, Dave ^b   Rausch, Steve ^b   Seely, Jim ^b  

^a AMGEN INC   (United States)

^b Amjen Inc   (United States)

^c Editorial Advisory Board ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTATION; FERMENTATION; MATHEMATICAL COMPUTING; MODEL; PARAMETERS OF MEASUREMENT AND ANALYSIS; PRACTICE GUIDELINE; REVIEW; VALIDATION PROCESS;

EID: 15244342436     PISSN: 1542166X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (4)

1. Dahlgren ME, Powell AL, Greasham RL, and George HA. Development of scale-down technique for investigation of recombinant Escherichia coli fermentations: Acid metabolites in shake flasks and stirred bioreactors, Biotechnol. Prog.1993; 9:580-586.
2. Reynolds T, Boychyn M, Sanderson T, Bulmer M, More J, and Hoare M. Scale-down of continuous filtration for rapid bioprocess design: Recovery and dewatering of protein precipitate suspensions, Biotech. Bioeng. 2003; 83:454-464.
3. Varga EG, Titchener-Hooker NJ, and Dunhill P. Prediction of the pilot-scale recovery of a recombinant yeast enzyme using integrated models, Biotechnol. Bioeng. 2001; 74:97-107.
4. Godavarti R, Petrone J, Robinson J, Wright R, and Kelley BD. Scale-down models for purification processes: Approaches and applications, in process validation in manufacturing of biopharmaceuticals, eds. Rathore AS and Sofer G. Marcel Dekker, New York 2005.