Development of a scaled-down aerobic fermentation model for scale-up in recombinant protein vaccine manufacturing

Vaccine

Volumn 30, Issue 38, 2012, Pages 5695-5698

  Farrell, Patrick ^a   Sun, Jacob ^a   Gao, Meg ^a   Sun, Hong ^a   Pattara, Ben ^a   Zeiser, Arno ^a   D'Amore, Tony ^a  

^a Bioprocess Research and Development   (Canada)

Author keywords

Fermentation; Recombinant protein; Scale down model

Indexed keywords

RECOMBINANT PROTEIN;

AEROBIC FERMENTATION; ARTICLE; BIOPROCESS; DRUG MANUFACTURE; ESCHERICHIA COLI; PRIORITY JOURNAL; SCALE UP;

AEROBIOSIS; BIOREACTORS; BIOTECHNOLOGY; ESCHERICHIA COLI; FERMENTATION; RECOMBINANT PROTEINS; TECHNOLOGY, PHARMACEUTICAL; VACCINES, SYNTHETIC;

EID: 84864776904     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.05.031     Document Type: Article

References (6)

1. van't Riet K. Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels. Industrial & Engineering Chemistry Process Design and Development 1979, 18(3):357-364.
2. Suzuki T., Tsuneo Y., Shimizu S. Phenomenological background some preliminary trials of automated substrate supply in pH-stat modal fed-batch culture using a setpoint of high limit. Journal of Fermentation and Bioengineering 1990, 69(5):292-297.
3. Taguchi H., Humphrey K. Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation systems. Journal of Fermentation 1966, 44:881-889.
4. Garcia-Ochoa F., Gomez E. Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnology Advances 2009, 27:153-176.
5. Bailey J.E., Ollis D.F. Biochemical engineering fundamentals 1986, McGraw-Hill, p. 488-94.
6. Charles M. Fermenter design and scale-up. Comprehensive biotechnology 1985, Pergamon Press, Oxford, p. 57-75. M. Moo-Young (Ed.).