Astrocytic metabolic and inflammatory changes as a function of age

Aging Cell

Volumn 13, Issue 6, 2014, Pages 1059-1067

  Jiang, Tianyi ^a   Cadenas, Enrique ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Astrocytes; Cytokines; Hydrogen peroxide; Inflammation; Mitochondria; Mitochondrial biogenesis; NF B; Nitric oxide

Indexed keywords

CYCLOOXYGENASE 3; DNA 18S; GLUCOSE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TUMOR NECROSIS FACTOR;

AEROBIC METABOLISM; AGE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOGENESIS; BRAIN CORTEX; BRAIN MITOCHONDRION; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; INFLAMMATION; INTRACELLULAR SIGNALING; MALE; MITOCHONDRIAL RESPIRATION; NEUROTOXICITY; NEUROTROPISM; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BRAIN; CELL AGING; CELL RESPIRATION; DRUG EFFECTS; ENERGY METABOLISM; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ASTROCYTES; BRAIN; CELL AGING; CELL RESPIRATION; ENERGY METABOLISM; HYDROGEN PEROXIDE; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MAP KINASE KINASE 4; MITOCHONDRIA; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84911397353     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12268     Document Type: Article

References (38)

1. Abramov AY, Duchen MR (2005) The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360, 2309-2314.
2. Abramov AY, Canevari L, Duchen MR (2004) Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim. Biophys. Acta 1742, 81-87.
3. Bal-Price A, Brown GC (2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 21, 6480-6491.
4. Belanger M, Magistretti PJ (2009) The role of astroglia in neuroprotection. Dialogues Clin. Neurosci. 11, 281-295.
5. Bolaños JP, Almeida A, Moncada S (2010) Glycolysis: a bioenergetic or a survival pathway? Trends Biochem. Sci. 35, 145-149.
6. Boumezbeur F, Mason G, De Graaf R, Behar K, Cline G, Shulman G, Rothman D, Petersen K (2010) Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J. Cereb. Blood Flow Metab. 30, 211-221.
7. Brosnan CF, Battistini L, Raine CS, Dickson DW, Casadevall A, Lee SC (1994) Reactive nitrogen intermediates in human neuropathology: an overview. Dev. Neurosci. 16, 152-161.
8. Campuzano O, Castillo-Ruiz MM, Acarin L, Castellano B, Gonzalez B (2009) Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage. J. Neurosci. Res. 87, 2484-2497.
9. Dienel GA, Hertz L (2001) Glucose and lactate metabolism during brain activation. J. Neurosci. Res. 66, 824-838.
10. Garcia-Matas S, Gutierrez-Cuesta J, Coto-Montes A, Rubio-Acero R, Diez-Vives C, Camins A, Pallas M, Sanfeliu C, Cristofol R (2008) Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity. Aging Cell 7, 630-640.
11. Gegg ME, Beltran B, Salas-Pino S, Bolaños JP, Clark JB, Moncada S, Heales SJ (2003) Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? J. Neurochem. 86, 228-237.
12. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M (2011) Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation. J. Exp. Med. 208, 1889-1900.
13. Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339, 218-222.
14. Jiang T, Yin F, Yao J, Brinton RD, Cadenas E (2013) Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1alpha transcriptional pathway. Aging Cell 12, 1021-1031.
15. Johnson AR, Milner JJ, Makowski L (2012) The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol. Rev. 249, 218-238.
16. Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734.
17. Loukili N, Rosenblatt-Velin N, Rolli J, Levrand S, Feihl F, Waeber B, Pacher P, Liaudet L (2010) Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner. J. Biol. Chem. 285, 15746-15752.
18. Luth HJ, Holzer M, Gartner U, Staufenbiel M, Arendt T (2001) Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res. 913, 57-67.
19. Magistretti PJ (2011) Neuron-glia metabolic coupling and plasticity. Exp. Physiol. 96, 407-410.
20. Mehan S, Meena H, Sharma D, Sankhla R (2011) JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J. Mol. Neurosci. 43, 376-390.
21. Morgan TE, Laping NJ, Rozovsky I, Oda T, Hogan TH, Finch CE, Pasinetti GM (1995) Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. J. Neuroimmunol. 58, 101-110.
22. Oliveira-Marques V, Silva T, Cunha F, Covas G, Marinho HS, Antunes F, Cyrne L (2013) A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-alpha. Redox Biol. 1, 347-352.
23. Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C (2005) NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J. Neurosci. 25, 1769-1777.
24. Park L, Anrather J, Girouard H, Zhou P, Iadecola C (2007) Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J. Cereb. Blood Flow Metab. 27, 1908-1918.
25. Piantadosi CA, Suliman HB (2012) Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim. Biophys. Acta 1820, 532-541.
26. Sorce S, Krause KH (2009) NOX enzymes in the central nervous system: from signaling to disease. Antioxid. Redox Signal. 11, 2481-2504.
27. Storz P, Toker A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J. 22, 109-120.
28. Storz P, Doppler H, Toker A (2004) Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol. Cell. Biol. 24, 2614-2626.
29. Suliman HB, Babiker A, Withers CM, Sweeney TE, Carraway MS, Tatro LG, Bartz RR, Welty-Wolf KE, Piantadosi CA (2010) Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. Free Radic. Biol. Med. 48, 736-746.
30. Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144, 810-823.
31. Takada Y, Mukhopadhyay A, Kundu GC, Mahabeleshwar GH, Singh S, Aggarwal BB (2003) Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J. Biol. Chem. 278, 24233-24241.
32. Thompson WL, Van Eldik LJ (2009) Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Brain Res. 1287, 47-57.
33. Wang MJ, Jeng KC, Kuo JS, Chen HL, Huang HY, Chen WF, Lin SZ (2004) c-Jun N-terminal kinase and, to a lesser extent, p38 mitogen-activated protein kinase regulate inducible nitric oxide synthase expression in hyaluronan fragments-stimulated BV-2 microglia. J. Neuroimmunol. 146, 50-62.
34. Yap LP, Garcia JV, Han D, Cadenas E (2010) Role of nitric oxide-mediated glutathionylation in neuronal function. Potential regulation of energy utilization. Biochem. J. 428, 85-93.
35. Yin F, Jiang T, Cadenas E (2013) Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling. Biochem. Soc. Trans. 41, 101-105.
36. Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D (2013) Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature 497, 211-216.
37. Zhou Q, Lam PY, Han D, Cadenas E (2008) c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J. Neurochem. 104, 325-335.
38. Zhou Q, Lam PY, Han D, Cadenas E (2009) Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett. 583, 1132-1140.