Amino acid changes in the influenza a virus PA protein that attenuate avian H5N1 viruses in mammals

Journal of Virology

Volumn 88, Issue 23, 2014, Pages 13737-13746

  Fan, Shufang ^a   Hatta, Masato ^a   Kim, Jin Hyun ^a,e   Le, Mai Quynh ^b   Neumann, Gabriele ^a   Kawaoka, Yoshihiro ^a,c,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NATIONAL INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Viet Nam)

^c UNIVERSITY OF TOKYO   (Japan)

^d Japan Science and Technology Agency   (Japan)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; LYSINE; PA PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; MUTANT PROTEIN; PA PROTEIN, INFLUENZA VIRUSES; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; MAMMAL CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN SUBUNIT; RESIDUE ANALYSIS; VIRUS ATTENUATION; VIRUS REPLICATION; VIRUS VIRULENCE; ADAPTATION; ANIMAL; AVIAN INFLUENZA; CELL LINE; CHICKEN; DISEASE MODEL; DOG; DUCK; GENETICS; HOST RANGE; INFLUENZA A VIRUS (H5N1); ISOLATION AND PURIFICATION; METABOLISM; MISSENSE MUTATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY; VIRULENCE;

AVES; INFLUENZA A VIRUS; MAMMALIA;

ADAPTATION, BIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CHICKENS; DISEASE MODELS, ANIMAL; DOGS; DUCKS; HOST SPECIFICITY; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; MICE; MUTANT PROTEINS; MUTATION, MISSENSE; ORTHOMYXOVIRIDAE INFECTIONS; RNA REPLICASE; VIRAL PROTEINS; VIRULENCE;

EID: 84911391694     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01081-14     Document Type: Article

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