Increased behavioral responses to ethanol in Lmo3 knockout mice

Genes, Brain and Behavior

Volumn 13, Issue 8, 2014, Pages 777-783

  Savarese, A ^a   Zou, M E ^b   Kharazia, V ^b   Maiya, R ^b,c   Lasek, A W ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Binge drinking; Ethanol; LMO3; Sedation

Indexed keywords

ALCOHOL; BETA GALACTOSIDASE; LIM DOMAIN ONLY 3 PROTEIN; LIM PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINGE DRINKING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; REPORTER GENE; RIGHTING REFLEX; SEDATION; SUBCORTEX; ANIMAL; ANIMAL BEHAVIOR; BRAIN; DECISION MAKING; DRINKING BEHAVIOR; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CHOICE BEHAVIOR; ETHANOL; LIM DOMAIN PROTEINS; MICE; MICE, KNOCKOUT;

EID: 84911370489     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12176     Document Type: Article

References (35)

1. Aoyama, M., Ozaki, T., Inuzuka, H., Tomotsune, D., Hirato, J., Okamoto, Y., Tokita, H., Ohira, M. & Nakagawara, A. (2005) LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res 65, 4587-4597.
2. Au, E., Ahmed, T., Karayannis, T., Biswas, S., Gan, L. & Fishell, G. (2013) A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells. Neuron 80, 1145-1158.
3. Bachmanov, A.A., Tordoff, M.G. & Beauchamp, G.K. (1996) Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J mice. Alcohol Clin Exp Res 20, 201-206.
4. Ben Hamida, S., Neasta, J., Lasek, A.W., Kharazia, V., Zou, M., Carnicella, S., Janak, P.H. & Ron, D. (2012) The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. J Neurosci 32, 15849-15858.
5. Bulchand, S., Subramanian, L. & Tole, S. (2003) Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Dev Dyn 226, 460-469.
6. Colasante, G., Collombat, P., Raimondi, V., Bonanomi, D., Ferrai, C., Maira, M., Yoshikawa, K., Mansouri, A., Valtorta, F., Rubenstein, J.L. & Broccoli, V. (2008) Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci 28, 10674-10686.
7. Cozzoli, D.K., Courson, J., Caruana, A.L., Miller, B.W., Greentree, D.I., Thompson, A.B., Wroten, M.G., Zhang, P.W., Xiao, B., Hu, J.H., Klugmann, M., Metten, P., Worley, P.F., Crabbe, J.C. & Szumlinski, K.K. (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol Clin Exp Res 36, 1623-1633.
8. Cozzoli, D.K., Courson, J., Wroten, M.G., Greentree, D.I., Lum, E.N., Campbell, R.R., Thompson, A.B., Maliniak, D., Worley, P.F., Jonquieres, G., Klugmann, M., Finn, D.A. & Szumlinski, K.K. (2014) Binge alcohol drinking by mice requires intact group1 metabotropic glutamate receptor signaling within the central nucleus of the amygdale. Neuropsychopharmacology 39, 435-444.
9. Crabbe, J.C., Spence, S.E., Brown, L.L. & Metten, P. (2011) Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol 45, 427-440.
10. Friocourt, G. & Parnavelas, J.G. (2011) Identification of Arx targets unveils new candidates for controlling cortical interneuron migration and differentiation. Front Cell Neurosci 5, 28.
11. Friocourt, G., Kanatani, S., Tabata, H., Yozu, M., Takahashi, T., Antypa, M., Raguenes, O., Chelly, J., Ferec, C., Nakajima, K. & Parnavelas, J.G. (2008) Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis. J Neurosci 28, 5794-5805.
12. Hinks, G.L., Shah, B., French, S.J., Campos, L.S., Staley, K., Hughes, J. & Sofroniew, M.V. (1997) Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci 17, 5549-5559.
13. Hu, J.H., Ma, Y.H., Yang, N., Mei, Z.T., Zhang, M.H., Fei, J. & Guo, L.H. (2004) Up-regulation of gamma-aminobutyric acid transporter I mediates ethanol sensitivity in mice. Neuroscience 123, 807-812.
14. Hui, L., Ji, C., Hui, B., Lv, T., Ha, X., Yang, J. & Cai, W. (2009) The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB. Brain Res 1265, 24-29.
15. Isogai, E., Ohira, M., Ozaki, T., Oba, S., Nakamura, Y. & Nakagawara, A. (2011) Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1. PLoS One 6, e19297.
16. Kapoor, M., Wang, J.C., Wetherill, L. et al. (2013) A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Hum Genet 132, 1141-1151.
17. Larsen, S., Yokochi, T., Isogai, E., Nakamura, Y., Ozaki, T. & Nakagawara, A. (2010) LMO3 interacts with p53 and inhibits its transcriptional activity. Biochem Biophys Res Commun 392, 252-257.
18. Lasek, A.W., Kapfhamer, D., Kharazia, V., Gesch, J., Giorgetti, F. & Heberlein, U. (2010) LMO4 in the nucleus accumbens regulates cocaine sensitivity. Genes Brain Behav 9, 817-824.
19. Lasek, A.W., Gesch, J., Giorgetti, F., Kharazia, V. & Heberlein, U. (2011a) Alk is a transcriptional target of LMO4 and ERalpha that promotes cocaine sensitization and reward. J Neurosci 31, 14134-14141.
20. Lasek, A.W., Giorgetti, F., Berger, K.H., Tayor, S. & Heberlein, U. (2011b) Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse. Alcohol Clin Exp Res 35, 1600-1606.
21. Lasek, A.W., Lim, J., Kliethermes, C.L., Berger, K.H., Joslyn, G., Brush, G., Xue, L., Robertson, M., Moore, M.S., Vranizan, K., Morris, S.W., Schuckit, M.A., White, R.L. & Heberlein, U. (2011c) An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One 6, e22636.
22. Lee, K., Mattiske, T., Kitamura, K., Gecz, J. & Shoubridge, C. (2014) Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation. Hum Mol Genet 23, 1084-1094.
23. Liljequist, S. & Engel, J. (1982) Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes. Psychopharmacology (Berl) 78, 71-75.
24. Liu, J., Yang, A.R., Kelly, T., Puche, A., Esoga, C., June, H.L. Jr., Elnabawi, A., Merchenthaler, I., Sieghart, W., June, H.L. Sr. & Aurelian, L. (2011) Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proc Natl Acad Sci U S A 108, 4465-4470.
25. Lowery-Gionta, E.G., Navarro, M., Li, C., Pleil, K.E., Rinker, J.A., Cox, B.R., Sprow, G.M., Kash, T.L. & Thiele, T.E. (2012) Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci 32, 3405-3413.
26. Matthews, J.M., Lester, K., Joseph, S. & Curtis, D.J. (2013) LIM-domain-only proteins in cancer. Nat Rev Cancer 13, 111-122.
27. Metz, A.V., Chynoweth, J. & Allan, A.M. (2006) Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice. Pharmacol Biochem Behav 84, 120-127.
28. Moore, E.M. & Boehm, S.L. 2nd (2009) Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice. Behav Neurosci 123, 555-563.
29. Moore, E.M., Serio, K.M., Goldfarb, K.J., Stepanovska, S., Linsenbardt, D.N. & Boehm, S.L. 2nd (2007) GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. Pharmacol Biochem Behav 88, 105-113.
30. Neasta, J., Ben Hamida, S., Yowell, Q.V., Carnicella, S. & Ron, D. (2011) AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry 70, 575-582.
31. Remedios, R., Subramanian, L. & Tole, S. (2004) LIM genes parcellate the embryonic amygdala and regulate its development. J Neurosci 24, 6986-6990.
32. Rhodes, J.S., Best, K., Belknap, J.K., Finn, D.A. & Crabbe, J.C. (2005) Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 84, 53-63.
33. Tsai, L.T., Bainton, R.J., Blau, J. & Heberlein, U. (2004) Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol 2, e408.
34. Tse, E., Smith, A.J., Hunt, S., Lavenir, I., Forster, A., Warren, A.J., Grutz, G., Foroni, L., Carlton, M.B., Colledge, W.H., Boehm, T. & Rabbitts, T.H. (2004) Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol 24, 2063-2073.
35. Zapata, A., Gonzales, R.A. & Shippenberg, T.S. (2006) Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice. Neuropsychopharmacology 31, 396-405.