LMO3 interacts with p53 and inhibits its transcriptional activity

Biochemical and Biophysical Research Communications

Volumn 392, Issue 3, 2010, Pages 252-257

  Larsen, Steven ^a   Yokochi, Tomoki ^a   Isogai, Eriko ^a   Nakamura, Yohko ^a   Ozaki, Toshinori ^a   Nakagawara, Akira ^a  

^a CHIBA CANCER CENTER   (Japan)

Author keywords

LIM only protein; LMO3; Neuroblastoma; Oncogene; p53; Tumor suppressor

Indexed keywords

MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN LMO3; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CHROMATIN; CONTROLLED STUDY; DNA BINDING; DNA RESPONSIVE ELEMENT; GENE ACTIVATION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MECHANICS; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; DNA; DNA-BINDING PROTEINS; HUMANS; NEOPLASMS; ONCOGENE PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 76349089965     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.010     Document Type: Article

References (28)

1. Brodeur G.M., Azar C., Brother M., et al. Neuroblastoma. Effect of genetic factors on prognosis and treatment. Cancer 70 (1992) 1685-1694
2. Maris J.M., Hogarty M.D., Bagatell R., et al. Neuroblastoma. Lancet 369 (2007) 2106-2120
3. Vogelstein B., Lane D., and Levine A.J. Surfing the p53 network. Nature 408 (2000) 307-310
4. Zhu J., Zhang S., Jiang J., et al. Definition of the p53 functional domains necessary for inducing apoptosis. J. Biol. Chem. 275 (2000) 39927-39934
5. Nikolaev A.Y., Li M., Puskas N., et al. Parc: a cytoplasmic anchor for p53. Cell 112 (2003) 29-40
6. Tse E., Smith A.J.H., Hunt S., et al. Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol. Cell. Biol. 24 (2004) 2063-2073
7. Arber S., Halder G., and Caroni P. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell 79 (1994) 221-231
8. Boehm T., Foroni L., Kaneko Y., et al. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl. Acad. Sci. USA 88 (1991) 4367-4371
9. Yamada Y., Warren A.J., Dobson C., et al. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc. Natl. Acad. Sci. USA 95 (1998) 3890-3895
10. Sum E.Y.M., Segara D., Duscio B., et al. Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. Proc. Natl. Acad. Sci. USA 102 (2005) 7659-7664
11. Mizunuma H., Miyazawa J., Sanada K., et al. The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. Br. J. Cancer 88 (2003) 1543-1548
12. Mousses S., Bubendorf L., Wagner U., et al. Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays. Cancer Res. 62 (2002) 1256-1260
13. Bao J., Talmage D.A., Role L.W., et al. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. Development 127 (2000) 425-435
14. Aoyama M., Ozaki T., Inuzuka H., et al. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res. 65 (2005) 4587-4597
15. Ohira M., Morohashi A., Inuzuka H., et al. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Oncogene 22 (2003) 5525-5536
16. Ando K., Ozaki T., Yamamoto H., et al. Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J. Biol. Chem. 279 (2004) 25549-25561
17. Koida N., Ozaki T., Yamamoto H., et al. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J. Biol. Chem. 283 (2008) 8555-8563
18. Niizuma H., Nakamura Y., Ozaki T., et al. Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. Oncogene 25 (2006) 5046-5055
19. Sum E.Y.M., Peng B., Yu X., et al. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J. Biol. Chem. 277 (2002) 7849-7856
20. Roth S.Y., Denu J.M., and Allis C.D. Histone acetyltransferases. Annu. Rev. Biochem. 70 (2001) 81-120
21. Barlev N.A., Liu L., Chehab N.H., et al. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8 (2001) 1243-1254
22. Espinosa J.M., and Emerson B.M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8 (2001) 57-69
23. An W., Kim J., and Roeder R.G. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell 117 (2004) 735-748
24. Kadrmas J.L., and Beckerle M.C. The LIM domain: from the cytoskeleton to the nucleus. Nat. Rev. Mol. Cell. Biol. 5 (2004) 920-931
25. Ostendorff H.P., Peirano R.I., Peters M.A., et al. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 416 (2002) 99-103
26. Simonis M., Klous P., Homminga I., et al. High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology. Nat. Methods 6 (2009) 837-842
27. Nam C., Lobato M.N., Appert A., et al. An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions. Oncogene 27 (2008) 4962-4968
28. Tanaka T., Williams R.L., and Rabbitts T.H. Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J. 26 (2007) 3250-3259