메뉴 건너뛰기
Journal of Virology
Volumn 88, Issue 23, 2014, Pages 13709-13721
Analysis of the evolution and structure of a complex intrahost viral population in chronic hepatitis C virus mapped by ultradeep pyrosequencing
Author keywords

[No Author keywords available]
Indexed keywords

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ARTICLE; HAPLOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS C VIRUS GENOTYPE 4; HEPATITIS C VIRUS GENOTYPE 4A; IMMUNE RESPONSE; LIVER CELL; MICROBIAL POPULATION DYNAMICS; MONOPHYLY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PYROSEQUENCING; VIRUS IDENTIFICATION; VIRUS RECOMBINATION; VIRUS REPLICATION; CHRONIC HEPATITIS C; CLASSIFICATION; GENETIC VARIATION; GENETICS; HEPACIVIRUS; HIGH THROUGHPUT SEQUENCING; HUMAN; LONGITUDINAL STUDY; MOLECULAR GENETICS; VIROLOGY;
EID: 84911366383     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01732-14     Document Type: Article
Times cited : (22)
References (65)
  • 1
    • 84876588538 scopus 로고    scopus 로고
    • Liver injury and disease pathogenesis in chronic hepatitis C
    • Yamane D, McGivern DR, Masaki T, Lemon SM. 2013. Liver injury and disease pathogenesis in chronic hepatitis C. Curr. Top. Microbiol. Immunol. 369:263-288. http://dx.doi.org/10.1007/978-3-642-27340-7_11.
    • (2013) Curr. Top. Microbiol. Immunol , vol.369 , pp. 263-288
    • Yamane, D.1    McGivern, D.R.2    Masaki, T.3    Lemon, S.M.4
  • 3
    • 0035000935 scopus 로고    scopus 로고
    • Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment
    • Penin F, Combet C, Germanidis G, Frainais PO, Deleage G, Pawlotsky JM. 2001. Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. J. Virol. 75:5703-5710. http://dx.doi.org/10.1128 /JVI.75.12.5703-5710.2001.
    • (2001) J. Virol , vol.75 , pp. 5703-5710
    • Penin, F.1    Combet, C.2    Germanidis, G.3    Frainais, P.O.4    Deleage, G.5    Pawlotsky, J.M.6
  • 4
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo.
    • von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P, McKeating JA. 2007. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 132:667-678. http://dx.doi.org/10.1053/j.gastro.2006 .12.008.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6    McKeating, J.A.7
  • 5
    • 77952709675 scopus 로고    scopus 로고
    • HepatitisCvirus transmission bottlenecks analyzed by deep sequencing
    • Wang GP, Sherrill-Mix SA, Chang KM, Quince C, Bushman FD. 2010. HepatitisCvirus transmission bottlenecks analyzed by deep sequencing. J. Virol. 84:6218-6228. http://dx.doi.org/10.1128/JVI.02271-09.
    • (2010) J. Virol , vol.84 , pp. 6218-6228
    • Wang, G.P.1    Sherrill-Mix, S.A.2    Chang, K.M.3    Quince, C.4    Bushman, F.D.5
  • 6
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature ofHCVgenome distribution.
    • Martell M, Esteban JI, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, Gomez J. 1992. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature ofHCVgenome distribution. J. Virol. 66:3225-3229.
    • (1992) J. Virol. , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6    Guardia, J.7    Gomez, J.8
  • 7
    • 40849097775 scopus 로고    scopus 로고
    • Rates of evolutionary change in viruses: patterns and determinants
    • Duffy S, Shackelton LA, Holmes EC. 2008. Rates of evolutionary change in viruses: patterns and determinants. Nat. Rev. Genet. 9:267-276. http: //dx.doi.org/10.1038/nrg2323.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 267-276
    • Duffy, S.1    Shackelton, L.A.2    Holmes, E.C.3
  • 8
    • 0027223705 scopus 로고
    • Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitisCvirus.
    • Kato N, Sekiya H, Ootsuyama Y, Nakazawa T, Hijikata M, Ohkoshi S, Shimotohno K. 1993. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitisCvirus. J. Virol. 67:3923-3930.
    • (1993) J. Virol. , vol.67 , pp. 3923-3930
    • Kato, N.1    Sekiya, H.2    Ootsuyama, Y.3    Nakazawa, T.4    Hijikata, M.5    Ohkoshi, S.6    Shimotohno, K.7
  • 10
    • 2942643931 scopus 로고    scopus 로고
    • Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity
    • Keck ZY, Sung VM, Perkins S, Rowe J, Paul S, Liang TJ, Lai MM, Foung SK. 2004. Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity. J. Virol. 78:7257- 7263. http://dx.doi.org/10.1128/JVI.78.13.7257-7263.2004.
    • (2004) J. Virol , vol.78 , pp. 7257-7263
    • Keck, Z.Y.1    Sung, V.M.2    Perkins, S.3    Rowe, J.4    Paul, S.5    Liang, T.J.6    Lai, M.M.7    Foung, S.K.8
  • 11
    • 70450162452 scopus 로고    scopus 로고
    • Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus
    • Broering TJ, Garrity KA, Boatright NK, Sloan SE, Sandor F, Thomas WD, Jr, Szabo G, Finberg RW, Ambrosino DM, Babcock GJ. 2009. Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus. J. Virol. 83:12473-12482. http://dx.doi.org/10 .1128/JVI.01138-09.
    • (2009) J. Virol , vol.83 , pp. 12473-12482
    • Broering, T.J.1    Garrity, K.A.2    Boatright, N.K.3    Sloan, S.E.4    Sandor, F.5    Thomas Jr., W.D.6    Szabo, G.7    Finberg, R.W.8    Ambrosino, D.M.9    Babcock, G.J.10
  • 14
    • 43249089764 scopus 로고    scopus 로고
    • Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C.
    • Li H, McMahon BJ, McArdle S, Bruden D, Sullivan DG, Shelton D, Deubner H, Gretch DR. 2008. Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C. Virology 375:580- 591. http://dx.doi.org/10.1016/j.virol.2008.02.012.
    • (2008) Virology , vol.375 , pp. 580-591
    • Li, H.1    McMahon, B.J.2    McArdle, S.3    Bruden, D.4    Sullivan, D.G.5    Shelton, D.6    Deubner, H.7    Gretch, D.R.8
  • 15
    • 22344447485 scopus 로고    scopus 로고
    • Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    • Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL. 2005. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J. Exp. Med. 201:1753-1759. http://dx.doi .org/10.1084/jem.20050122.
    • (2005) J. Exp. Med , vol.201 , pp. 1753-1759
    • Ray, S.C.1    Fanning, L.2    Wang, X.H.3    Netski, D.M.4    Kenny-Walsh, E.5    Thomas, D.L.6
  • 16
    • 84869214171 scopus 로고    scopus 로고
    • Insertion and recombination events at hypervariable region 1 over 9.6 years of hepatitis C virus chronic infection
    • Palmer BA, Moreau I, Levis J, Harty C, Crosbie O, Kenny-Walsh E, Fanning LJ. 2012. Insertion and recombination events at hypervariable region 1 over 9.6 years of hepatitis C virus chronic infection. J. Gen. Virol. 93:2614-2624. http://dx.doi.org/10.1099/vir.0.045344-0.
    • (2012) J. Gen. Virol , vol.93 , pp. 2614-2624
    • Palmer, B.A.1    Moreau, I.2    Levis, J.3    Harty, C.4    Crosbie, O.5    Kenny-Walsh, E.6    Fanning, L.J.7
  • 17
    • 79960848222 scopus 로고    scopus 로고
    • Temporal variations in the hepatitis C virus intrahost population during chronic infection
    • Ramachandran S, Campo DS, Dimitrova ZE, Xia GL, Purdy MA, Khudyakov YE. 2011. Temporal variations in the hepatitis C virus intrahost population during chronic infection. J. Virol. 85:6369-6380. http: //dx.doi.org/10.1128/JVI.02204-10.
    • (2011) J. Virol , vol.85 , pp. 6369-6380
    • Ramachandran, S.1    Campo, D.S.2    Dimitrova, Z.E.3    Xia, G.L.4    Purdy, M.A.5    Khudyakov, Y.E.6
  • 19
    • 80054987354 scopus 로고    scopus 로고
    • The hepatitis C virus glycan shield and evasion of the humoral immune response.
    • Helle F, Duverlie G, Dubuisson J. 2011. The hepatitis C virus glycan shield and evasion of the humoral immune response. Viruses 3:1909- 1932. http://dx.doi.org/10.3390/v3101909.
    • (2011) Viruses , vol.3 , pp. 1909-1932
    • Helle, F.1    Duverlie, G.2    Dubuisson, J.3
  • 24
    • 84901624146 scopus 로고    scopus 로고
    • Comparative analysis of the molecular mechanisms of recombination in hepatitisCvirus.
    • Galli A, Bukh J. 2014. Comparative analysis of the molecular mechanisms of recombination in hepatitisCvirus. Trends Microbiol 22:354-364. http: //dx.doi.org/10.1016/j.tim.2014.02.005.
    • (2014) Trends Microbiol , vol.22 , pp. 354-364
    • Galli, A.1    Bukh, J.2
  • 27
    • 84875984443 scopus 로고    scopus 로고
    • Productive homologous and non-homologous recombination of hepatitis C virus in cell culture
    • Scheel TK, Galli A, Li YP, Mikkelsen LS, Gottwein JM, Bukh J. 2013. Productive homologous and non-homologous recombination of hepatitis C virus in cell culture. PLoS Pathog. 9:e1003228. http://dx.doi.org/10 .1371/journal.ppat.1003228.
    • (2013) PLoS Pathog , vol.9
    • Scheel, T.K.1    Galli, A.2    Li, Y.P.3    Mikkelsen, L.S.4    Gottwein, J.M.5    Bukh, J.6
  • 28
    • 75549083380 scopus 로고    scopus 로고
    • Reducing the impact of PCR-mediated recombination in molecular evolution and environmental studies using a newgeneration high-fidelity DNA polymerase.
    • Lahr DJ, Katz LA. 2009. Reducing the impact of PCR-mediated recombination in molecular evolution and environmental studies using a newgeneration high-fidelity DNA polymerase. Biotechniques 47:857-866.
    • (2009) Biotechniques , vol.47 , pp. 857-866
    • Lahr, D.J.1    Katz, L.A.2
  • 29
    • 0024973417 scopus 로고
    • Avoiding false positives with PCR.
    • Kwok S, Higuchi R. 1989. Avoiding false positives with PCR. Nature 339:237-238. http://dx.doi.org/10.1038/339237a0.
    • (1989) Nature , vol.339 , pp. 237-238
    • Kwok, S.1    Higuchi, R.2
  • 30
    • 53249090243 scopus 로고    scopus 로고
    • Separation of hepatitis C genotype 4a into IgG-depleted and IgG-enriched fractions reveals a unique quasispecies profile
    • Moreau I, O'Sullivan H, Murray C, Levis J, Crosbie O, Kenny-Walsh E, Fanning LJ. 2008. Separation of hepatitis C genotype 4a into IgG-depleted and IgG-enriched fractions reveals a unique quasispecies profile. Virol. J. 5:103. http://dx.doi.org/10.1186/1743-422X-5-103.
    • (2008) Virol. J , vol.5 , pp. 103
    • Moreau, I.1    O'Sullivan, H.2    Murray, C.3    Levis, J.4    Crosbie, O.5    Kenny-Walsh, E.6    Fanning, L.J.7
  • 32
    • 59949093527 scopus 로고    scopus 로고
    • De novo fragment assembly with short mate-paired reads: does the read length matter?
    • Chaisson MJ, Brinza D, Pevzner PA. 2009. De novo fragment assembly with short mate-paired reads: does the read length matter? Genome Res. 19:336-346. http://dx.doi.org/10.1101/gr.079053.108.
    • (2009) Genome Res. , vol.19 , pp. 336-346
    • Chaisson, M.J.1    Brinza, D.2    Pevzner, P.A.3
  • 33
    • 39049156065 scopus 로고    scopus 로고
    • Short read fragment assembly of bacterial genomes
    • Chaisson MJ, Pevzner PA. 2008. Short read fragment assembly of bacterial genomes. Genome Res. 18:324-330. http://dx.doi.org/10.1101/gr .7088808.
    • (2008) Genome Res , vol.18 , pp. 324-330
    • Chaisson, M.J.1    Pevzner, P.A.2
  • 34
    • 78349249371 scopus 로고    scopus 로고
    • EDAR: an efficient error detection and removal algorithm for next generation sequencing data
    • Zhao X, Palmer LE, Bolanos R, Mircean C, Fasulo D, Wittenberg GM. 2010. EDAR: an efficient error detection and removal algorithm for next generation sequencing data. J. Comput. Biol. 17:1549-1560. http://dx.doi .org/10.1089/cmb.2010.0127.
    • (2010) J. Comput. Biol , vol.17 , pp. 1549-1560
    • Zhao, X.1    Palmer, L.E.2    Bolanos, R.3    Mircean, C.4    Fasulo, D.5    Wittenberg, G.M.6
  • 36
    • 30744470609 scopus 로고    scopus 로고
    • Application of phylogenetic networks in evolutionary studies
    • Huson DH, Bryant D. 2006. Application of phylogenetic networks in evolutionary studies. Mol. Biol. Evol. 23:254-267. http://dx.doi.org/10 .1093/molbev/msj030.
    • (2006) Mol. Biol. Evol , vol.23 , pp. 254-267
    • Huson, D.H.1    Bryant, D.2
  • 37
    • 33646167864 scopus 로고    scopus 로고
    • A simple and robust statistical test for detecting the presence of recombination.
    • Bruen TC, Philippe H, Bryant D. 2006. A simple and robust statistical test for detecting the presence of recombination. Genetics 172:2665-2681. http://dx.doi.org/10.1534/genetics.105.048975.
    • (2006) Genetics , vol.172 , pp. 2665-2681
    • Bruen, T.C.1    Philippe, H.2    Bryant, D.3
  • 38
    • 0032889281 scopus 로고    scopus 로고
    • Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination.
    • Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, Ingersoll R, Sheppard HW, Ray SC. 1999. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J. Virol. 73:152-160.
    • (1999) J. Virol , vol.73 , pp. 152-160
    • Lole, K.S.1    Bollinger, R.C.2    Paranjape, R.S.3    Gadkari, D.4    Kulkarni, S.S.5    Novak, N.G.6    Ingersoll, R.7    Sheppard, H.W.8    Ray, S.C.9
  • 39
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
    • Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28:2731-2739. http://dx.doi.org/10.1093/molbev/msr121.
    • (2011) Mol. Biol. Evol , vol.28 , pp. 2731-2739
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 40
    • 49749094696 scopus 로고    scopus 로고
    • A maximum likelihood method for detecting directional evolution in protein sequences and its application to influenza A virus
    • Kosakovsky Pond SL, Poon AF, Leigh Brown AJ, Frost SD. 2008. A maximum likelihood method for detecting directional evolution in protein sequences and its application to influenza A virus. Mol. Biol. Evol. 25:1809-1824. http://dx.doi.org/10.1093/molbev/msn123.
    • (2008) Mol. Biol. Evol , vol.25 , pp. 1809-1824
    • Kosakovsky Pond, S.L.1    Poon, A.F.2    Leigh Brown, A.J.3    Frost, S.D.4
  • 41
    • 50549084385 scopus 로고    scopus 로고
    • Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models.
    • Poon AF, Lewis FI, Frost SD, Kosakovsky Pond SL. 2008. Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models. Bioinformatics 24:1949-1950. http://dx.doi.org/10.1093/bioinformatics /btn313.
    • (2008) Bioinformatics , vol.24 , pp. 1949-1950
    • Poon, A.F.1    Lewis, F.I.2    Frost, S.D.3    Kosakovsky Pond, S.L.4
  • 42
    • 36948998606 scopus 로고    scopus 로고
    • An evolutionarynetwork model reveals stratified interactions in the V3 loop of the HIV-1 envelope
    • Poon AF, Lewis FI, Pond SL, Frost SD. 2007. An evolutionarynetwork model reveals stratified interactions in the V3 loop of the HIV-1 envelope. PLoS Comput. Biol. 3:e231. http://dx.doi.org/10 .1371/journal.pcbi.0030231.
    • (2007) PLoS Comput. Biol , vol.3
    • Poon, A.F.1    Lewis, F.I.2    Pond, S.L.3    Frost, S.D.4
  • 43
    • 0033594380 scopus 로고    scopus 로고
    • Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin.
    • Kenny-Walsh E. 1999. Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. N. Engl. J. Med. 340:1228-1233.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1228-1233
    • Kenny-Walsh, E.1
  • 46
    • 0036906969 scopus 로고    scopus 로고
    • Constrained genomic and conformational variability of the hypervariable region 1 of hepatitis C virus in chronically infected patients
    • Hino K, Korenaga M, Orito E, Katoh Y, Yamaguchi Y, Ren F, Kitase A, Satoh Y, Fujiwara D, Okita K. 2002. Constrained genomic and conformational variability of the hypervariable region 1 of hepatitis C virus in chronically infected patients. J. Viral Hepat. 9:194-201. http://dx.doi.org /10.1046/j.1365-2893.2002.00349.x.
    • (2002) J. Viral Hepat , vol.9 , pp. 194-201
    • Hino, K.1    Korenaga, M.2    Orito, E.3    Katoh, Y.4    Yamaguchi, Y.5    Ren, F.6    Kitase, A.7    Satoh, Y.8    Fujiwara, D.9    Okita, K.10
  • 47
    • 55049120771 scopus 로고    scopus 로고
    • An exploratory algorithm to identify intra-host recombinant viral sequences
    • Salemi M, Gray RR, Goodenow MM. 2008. An exploratory algorithm to identify intra-host recombinant viral sequences. Mol. Phylogenet. Evol. 49:618-628. http://dx.doi.org/10.1016/j.ympev.2008.08.017.
    • (2008) Mol. Phylogenet. Evol , vol.49 , pp. 618-628
    • Salemi, M.1    Gray, R.R.2    Goodenow, M.M.3
  • 49
    • 77956152508 scopus 로고    scopus 로고
    • The impact of PCR-generated recombination on diversity estimation of mixed viral populations by deep sequencing.
    • Görzer I, Guelly C, Trajanoski S, Puchhammer-Stöckl E. 2010. The impact of PCR-generated recombination on diversity estimation of mixed viral populations by deep sequencing. J. Virol. Methods 169:248-252. http://dx.doi.org/10.1016/j.jviromet.2010.07.040.
    • (2010) J. Virol. Methods , vol.169 , pp. 248-252
    • Görzer, I.1    Guelly, C.2    Trajanoski, S.3    Puchhammer-Stöckl, E.4
  • 52
    • 84873040161 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry
    • Carlsen TH, Scheel TK, Ramirez S, Foung SK, Bukh J. 2013. Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry. J. Virol. 87:1385-1399. http://dx.doi.org/10.1128/JVI .00684-12.
    • (2013) J. Virol , vol.87 , pp. 1385-1399
    • Carlsen, T.H.1    Scheel, T.K.2    Ramirez, S.3    Foung, S.K.4    Bukh, J.5
  • 53
    • 0036196640 scopus 로고    scopus 로고
    • A natural intergenotypic recombinant of hepatitis C virus identified in St
    • Kalinina O, Norder H, Mukomolov S, Magnius LO. 2002. A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg. J. Virol. 76:4034-4043. http://dx.doi.org/10.1128/JVI.76.8.4034 -4043.2002.
    • (2002) Petersburg. J. Virol , vol.76 , pp. 4034-4043
    • Kalinina, O.1    Norder, H.2    Mukomolov, S.3    Magnius, L.O.4
  • 56
    • 77957658175 scopus 로고    scopus 로고
    • Quasispecies theory and the behavior of RNAviruses
    • Lauring AS, Andino R. 2010. Quasispecies theory and the behavior of RNAviruses. PLoS Pathog. 6:e1001005. http://dx.doi.org/10.1371/journal .ppat.1001005.
    • (2010) PLoS Pathog , vol.6
    • Lauring, A.S.1    Andino, R.2
  • 58
    • 0025570214 scopus 로고
    • RNA virus quasispecies populations can suppress vastly superior mutant progeny.
    • de la Torre JC, Holland JJ. 1990. RNA virus quasispecies populations can suppress vastly superior mutant progeny. J. Virol. 64:6278-6281.
    • (1990) J. Virol. , vol.64 , pp. 6278-6281
    • de la Torre, J.C.1    Holland, J.J.2
  • 59
    • 84871993454 scopus 로고    scopus 로고
    • Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis
    • Webster B, Wissing S, Herker E, Ott M, Greene WC. 2013. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J. Virol. 87:581-596. http://dx.doi.org/10.1128/JVI.01047-12.
    • (2013) J. Virol , vol.87 , pp. 581-596
    • Webster, B.1    Wissing, S.2    Herker, E.3    Ott, M.4    Greene, W.C.5
  • 60
    • 84884954835 scopus 로고    scopus 로고
    • Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children.
    • Gismondi MI, Díaz Carrasco JM, Valva P, Becker PD, Guzmán CA, Campos RH, Preciado MV. 2013. Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children. Virology 447:187-196. http://dx.doi.org/10.1016/j .virol.2013.09.002.
    • (2013) Virology , vol.447 , pp. 187-196
    • Gismondi, M.I.1    Díaz Carrasco, J.M.2    Valva, P.3    Becker, P.D.4    Guzmán, C.A.5    Campos, R.H.6    Preciado, M.V.7
  • 62
    • 84869210366 scopus 로고    scopus 로고
    • Constraints on viral evolution during chronic hepatitis C virus infection arising from a common-source exposure
    • Bailey JR, Laskey S, Wasilewski LN, Munshaw S, Fanning LJ, Kenny-Walsh E, Ray SC. 2012. Constraints on viral evolution during chronic hepatitis C virus infection arising from a common-source exposure. J. Virol. 86:12582-12590. http://dx.doi.org/10.1128/JVI.01440-12.
    • (2012) J. Virol , vol.86 , pp. 12582-12590
    • Bailey, J.R.1    Laskey, S.2    Wasilewski, L.N.3    Munshaw, S.4    Fanning, L.J.5    Kenny-Walsh, E.6    Ray, S.C.7
  • 65
    • 7444221704 scopus 로고    scopus 로고
    • The contribution of epistasis to the architecture of fitness in an RNA virus
    • Sanjuán R, Moya A, Elena SF. 2004. The contribution of epistasis to the architecture of fitness in an RNA virus. Proc. Natl. Acad. Sci. U. S. A. 101:15376-15379. http://dx.doi.org/10.1073/pnas.0404125101.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 15376-15379
    • Sanjuán, R.1    Moya, A.2    Elena, S.F.3

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.