-
2
-
-
84892805731
-
Cancer statistics, 2014
-
Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
3
-
-
83655198773
-
Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma
-
Jain S, Diefenbach C, Zain J, et al. Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma. Core Evid 2011;6:43-57
-
(2011)
Core Evid
, vol.6
, pp. 43-57
-
-
Jain, S.1
Diefenbach, C.2
Zain, J.3
-
5
-
-
72549116835
-
A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
-
O'Connor OA, Stewart AK, Vallone M, et al. A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res 2009;15:7085-91
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7085-7091
-
-
O'Connor, O.A.1
Stewart, A.K.2
Vallone, M.3
-
6
-
-
50249092779
-
Development of proteasome inhibitors in oncology and autoimmune diseases
-
Bennett MK, Kirk CJ. Development of proteasome inhibitors in oncology and autoimmune diseases. Curr Opin Drug Discov Devel 2008;11:616-25
-
(2008)
Curr Opin Drug Discov Devel
, vol.11
, pp. 616-625
-
-
Bennett, M.K.1
Kirk, C.J.2
-
7
-
-
0027980319
-
Inhibitors of the proteasome block the degradation of most cell proteins and the generations of peptides presented on most MHC class I molecules
-
Rock KL, Gramm C, Rothstein L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generations of peptides presented on most MHC class I molecules. Cell 1994;78:761-71
-
(1994)
Cell
, vol.78
, pp. 761-771
-
-
Rock, K.L.1
Gramm, C.2
Rothstein, L.3
-
8
-
-
84862672118
-
Biologic impact of proteasome inhibition in multiple myeloma cells - From the aspects of preclinical studies
-
Hideshima T, Anderson KC. Biologic impact of proteasome inhibition in multiple myeloma cells - from the aspects of preclinical studies. Semin Hematol 2012;49:223-7
-
(2012)
Semin Hematol
, vol.49
, pp. 223-227
-
-
Hideshima, T.1
Anderson, K.C.2
-
9
-
-
84871020567
-
Molecular mechanisms of acquired proteasome inhibitor resistance
-
Kale AJ, Moore BS. Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem 2012;55:10317-27
-
(2012)
J Med Chem
, vol.55
, pp. 10317-10327
-
-
Kale, A.J.1
Moore, B.S.2
-
10
-
-
84862680002
-
The proteasome in terminal plasma cell differentiation
-
Cenci S. The proteasome in terminal plasma cell differentiation. Semin Hematol 2012;49:215-22
-
(2012)
Semin Hematol
, vol.49
, pp. 215-222
-
-
Cenci, S.1
-
11
-
-
84864773480
-
DangER: Protein overload. Targeting protein degradation to treat myeloma
-
Aronson LI, Davies FE. DangER: protein overload. Targeting protein degradation to treat myeloma. Haematologica 2012;97:1119-30
-
(2012)
Haematologica
, vol.97
, pp. 1119-1130
-
-
Aronson, L.I.1
Davies, F.E.2
-
13
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008;359:906-17
-
(2008)
N Engl J Med
, vol.359
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
14
-
-
3042577683
-
Approval summary for bortezomib for injection in the treatment of multiple myeloma
-
Bross PF, Kane R, Farrell AT, et al. Approval summary for bortezomib for injection in the treatment of multiple myeloma. Clin Cancer Res 2004;10:3954-64
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3954-3964
-
-
Bross, P.F.1
Kane, R.2
Farrell, A.T.3
-
15
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
Chauhan D, Catley L, Li G, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 2005;8:407-19
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
-
16
-
-
33744832401
-
United States Food and Drug Administration Approval Summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy
-
Kane RC, Farrell A, Sridhara R, et al. United States Food and Drug Administration Approval Summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin Cancer Res 2006;12:2955-60
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2955-2960
-
-
Kane, R.C.1
Farrell, A.2
Sridhara, R.3
-
18
-
-
27744557499
-
Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma
-
Zangari M, Esseltine D, Lee CK, et al. Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma. Br J Haematol 2005;131:71-3
-
(2005)
Br J Haematol
, vol.131
, pp. 71-73
-
-
Zangari, M.1
Esseltine, D.2
Lee, C.K.3
-
20
-
-
84884132334
-
Continued improvement in survival in multiple myeloma and the impact of novel agents
-
abstract 3972
-
Kumar SK, Dispenzieri A, Gertz MA, et al. Continued improvement in survival in multiple myeloma and the impact of novel agents. Blood 2012;120:abstract 3972
-
(2012)
Blood
, vol.120
-
-
Kumar, S.K.1
Dispenzieri, A.2
Gertz, M.A.3
-
21
-
-
78650303860
-
Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised phase 3 study
-
Cavo M, Tacchetti P, Patriarca F, et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. Lancet 2010;376:2075-85
-
(2010)
Lancet
, vol.376
, pp. 2075-2085
-
-
Cavo, M.1
Tacchetti, P.2
Patriarca, F.3
-
22
-
-
82155178738
-
Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
-
Moreau P, Avet-Loiseau H, Facon T, et al. Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma. Blood 2011;118:5752-8
-
(2011)
Blood
, vol.118
, pp. 5752-5758
-
-
Moreau, P.1
Avet-Loiseau, H.2
Facon, T.3
-
23
-
-
79951702955
-
Bortezomib as the first proteasome inhibitor anticancer drug: Current status and future perspectives
-
Chen D, Frezza M, Schmitt S, et al. Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. Curr Cancer Drug Targets 2011;11:239-53
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 239-253
-
-
Chen, D.1
Frezza, M.2
Schmitt, S.3
-
24
-
-
79955461011
-
Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study
-
Moreau P, Pylypenko H, Grosicki S, et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011;12:431-4
-
(2011)
Lancet Oncol
, vol.12
, pp. 431-434
-
-
Moreau, P.1
Pylypenko, H.2
Grosicki, S.3
-
25
-
-
84871311301
-
-
Onyx Pharmaceuticals, South San Francisco, CA
-
Kyprolis [package insert]. Onyx Pharmaceuticals, South San Francisco, CA; 2012
-
(2012)
Kyprolis [Package Insert]
-
-
-
26
-
-
41949114641
-
Recent major improvement in long-term survival of younger patients with multiple myeloma
-
Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008;111:2521-6
-
(2008)
Blood
, vol.111
, pp. 2521-2526
-
-
Brenner, H.1
Gondos, A.2
Pulte, D.3
-
27
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008;111:2516-20
-
(2008)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
28
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo SD, Kirk CJ, Aujay MA, et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 2007;67:6383-91
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
-
29
-
-
0343262654
-
Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis of α′, β′-epoxyketone proteasome inhibitors
-
Groll M, Kim KB, Kairies N, et al. Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis of α′, β′-epoxyketone proteasome inhibitors. J Am Chem Soc 2000;122:1237-8
-
(2000)
J Am Chem Soc
, vol.122
, pp. 1237-1238
-
-
Groll, M.1
Kim, K.B.2
Kairies, N.3
-
30
-
-
0032539702
-
Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
-
Adams J, Behnke M, Chen S, et al. Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett 1998;8:333-8
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 333-338
-
-
Adams, J.1
Behnke, M.2
Chen, S.3
-
31
-
-
79955498420
-
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
-
Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res 2011;17:2734-43
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2734-2743
-
-
Arastu-Kapur, S.1
Anderl, J.L.2
Kraus, M.3
-
32
-
-
33745086150
-
Biochemical and cellular characterization of the novel proteasome inhibitor PR-171
-
abstract 1588
-
Demo SD, Buchholz TJ, Laidig GJ, et al. Biochemical and cellular characterization of the novel proteasome inhibitor PR-171. Blood 2005;106:abstract 1588
-
(2005)
Blood
, vol.106
-
-
Demo, S.D.1
Buchholz, T.J.2
Laidig, G.J.3
-
33
-
-
33847410207
-
The proteasome inhbitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells
-
Stapnes C, Døskeland AP, Hatfield K, et al. The proteasome inhbitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. Br J Haematol 2007;136:814-28
-
(2007)
Br J Haematol
, vol.136
, pp. 814-828
-
-
Stapnes, C.1
Døskeland, A.P.2
Hatfield, K.3
-
34
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-roteasome pathway, against preclinical models of multiple myeloma
-
Kuhn DJ, Chen Q, Voorhees PM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-roteasome pathway, against preclinical models of multiple myeloma. Blood 2007;110:3281-90
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
-
35
-
-
80053148350
-
Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats
-
Yang J, Wang Z, Fang Y, et al. Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metab Dispos 2011;39:1873-82
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 1873-1882
-
-
Yang, J.1
Wang, Z.2
Fang, Y.3
-
36
-
-
84871545425
-
Clinical pharmacokinetics, metabolism, and drug-rug interaction of carfilzomib
-
Wang Z, Yang J, Kirk C, et al. Clinical pharmacokinetics, metabolism, and drug-rug interaction of carfilzomib. Drug Metab Dispos 2013;41:230-7
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 230-237
-
-
Wang, Z.1
Yang, J.2
Kirk, C.3
-
37
-
-
84865712581
-
A phase I single-agent study of twice-weekly consecutive day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma
-
Alsina M, Trudel S, Furman RR, et al. A phase I single-agent study of twice-weekly consecutive day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma. Clin Cancer Res 2012;18:4830-40
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4830-4840
-
-
Alsina, M.1
Trudel, S.2
Furman, R.R.3
-
38
-
-
84881480747
-
Carfilzomib in multiple myeloma patients with renal impairment: Pharmacokinetics and safety
-
Badros AZ, Vij R, Martin T, et al. Carfilzomib in multiple myeloma patients with renal impairment: pharmacokinetics and safety. Leukemia 2013;27:1707-14
-
(2013)
Leukemia
, vol.27
, pp. 1707-1714
-
-
Badros, A.Z.1
Vij, R.2
Martin, T.3
-
40
-
-
84865552564
-
An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
-
Vij R, Siegel D, Jagannath S, et al. An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br J Haematol 2012;158:739-48
-
(2012)
Br J Haematol
, vol.158
, pp. 739-748
-
-
Vij, R.1
Siegel, D.2
Jagannath, S.3
-
41
-
-
84862507585
-
An open-label, single-arm, phase 2 (PX-171-004) study of single agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
-
Vij R, Wang M, Kaufman JL, et al. An open-label, single-arm, phase 2 (PX-171-004) study of single agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma. Blood 2012;119:5661-70
-
(2012)
Blood
, vol.119
, pp. 5661-5670
-
-
Vij, R.1
Wang, M.2
Kaufman, J.L.3
-
42
-
-
84867295563
-
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
-
Siegel DS, Martin T, Wang M, et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood 2012;120:2817-25
-
(2012)
Blood
, vol.120
, pp. 2817-2825
-
-
Siegel, D.S.1
Martin, T.2
Wang, M.3
-
43
-
-
84856719479
-
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter International Myeloma Working Group study
-
Kumar SK, Lee JH, Lahuerta JJ, et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter International Myeloma Working Group study. Leukemia 2012;26:149-57
-
(2012)
Leukemia
, vol.26
, pp. 149-157
-
-
Kumar, S.K.1
Lee, J.H.2
Lahuerta, J.J.3
-
44
-
-
84911112341
-
A phase 1 study of 30-minute infusion of single-agent carfilzomib or in combination with low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma
-
In press
-
Papadopoulos KP, Siegel DS, Vesole DH, et al. A phase 1 study of 30-minute infusion of single-agent carfilzomib or in combination with low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma. J Clin Oncol 2014; In press
-
(2014)
J Clin Oncol
-
-
Papadopoulos, K.P.1
Siegel, D.S.2
Vesole, D.H.3
-
45
-
-
84911112340
-
A phase 1, dose-escalation study (CHAMPION-1) investigating weekly carfilzomib in combination with dexamethasone for patients with relapsed or refractory multiple myeloma
-
abstract 1934. Presented at
-
Berenson JR, Klein L, Rifkin RM, et al. A phase 1, dose-escalation study (CHAMPION-1) investigating weekly carfilzomib in combination with dexamethasone for patients with relapsed or refractory multiple myeloma [abstract 1934]. Presented at: 55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
-
Berenson, J.R.1
Klein, L.2
Rifkin, R.M.3
-
46
-
-
84911112339
-
Results of the dose-escalation portion of a phase 1/2 study (CHAMPION-1) investigating weekly carfilzomib in combination with dexamethasone for patients with relapsed or refractory multiple myeloma
-
abstract 8594. Presented at
-
Berenson JR, Klein L, Rifkin RM, et al. Results of the dose-escalation portion of a phase 1/2 study (CHAMPION-1) investigating weekly carfilzomib in combination with dexamethasone for patients with relapsed or refractory multiple myeloma [abstract 8594]. Presented at: annual Meeting of the American Society of Clinical Oncology (ASCO); May 30 - June 3 2014; Chicago, Illinois
-
Annual Meeting of the American Society of Clinical Oncology (ASCO); May 30 - June 3 2014; Chicago, Illinois
-
-
Berenson, J.R.1
Klein, L.2
Rifkin, R.M.3
-
47
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002;99:4525-30
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
48
-
-
84893289821
-
A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma
-
Richardson PG, Xie W, Jagannath S, et al. A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. Blood 2014;123:1461-9
-
(2014)
Blood
, vol.123
, pp. 1461-1469
-
-
Richardson, P.G.1
Xie, W.2
Jagannath, S.3
-
49
-
-
73349115580
-
Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
-
Richardson PG, Weller E, Jagannath S, et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009;27:5713-19
-
(2009)
J Clin Oncol
, vol.27
, pp. 5713-5719
-
-
Richardson, P.G.1
Weller, E.2
Jagannath, S.3
-
50
-
-
79952729549
-
Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple myeloma (MM): Updated efficacy and safety data after >2 years of follow-up
-
abstract 3049
-
Richardson PG, Jagannath S, Jakubowiak AJ, et al. Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple myeloma (MM): updated efficacy and safety data after >2 years of follow-up. Blood 2010;116:abstract 3049
-
(2010)
Blood
, vol.116
-
-
Richardson, P.G.1
Jagannath, S.2
Jakubowiak, A.J.3
-
51
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61:3071-6
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
52
-
-
84877089105
-
Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
-
Niesvizky R, Martin TG III, Bensinger WI, et al. Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res 2013;19:2248-56
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2248-2256
-
-
Niesvizky, R.1
Martin, T.G.2
Bensinger, W.I.3
-
53
-
-
84899966250
-
Evolution of carfilzomib dose and schedule in patients with multiple myeloma: A historical overview
-
Jakubowiak AJ. Evolution of carfilzomib dose and schedule in patients with multiple myeloma: a historical overview. Cancer Treat Rev 2014;40:781-90
-
(2014)
Cancer Treat Rev
, vol.40
, pp. 781-790
-
-
Jakubowiak, A.J.1
-
54
-
-
84887609779
-
Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
-
Wang M, Martin T, Bensinger W, et al. Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Blood 2013;122:3122-8
-
(2013)
Blood
, vol.122
, pp. 3122-3128
-
-
Wang, M.1
Martin, T.2
Bensinger, W.3
-
56
-
-
84866341173
-
CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma
-
Sanchez E, Li M, Li J, et al. CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma. Leuk Res 2012;36:1422-7
-
(2012)
Leuk Res
, vol.36
, pp. 1422-1427
-
-
Sanchez, E.1
Li, M.2
Li, J.3
-
57
-
-
84904054234
-
Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy
-
Berenson JR, Hilger JD, Yellin O, et al. Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy. Leukemia 2014;28(7):1529-36
-
(2014)
Leukemia
, vol.28
, Issue.7
, pp. 1529-1536
-
-
Berenson, J.R.1
Hilger, J.D.2
Yellin, O.3
-
58
-
-
84993722060
-
A single-arm, open-label, multi-center phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed or relapse/refractory multiple myeloma
-
2013 ASH Annual Meeting; New Orleans. abstract 1937
-
Berdeja JG, Savona M, Mace JR, et al. A single-arm, open-label, multi-center phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed or relapse/refractory multiple myeloma. 2013 ASH Annual Meeting; New Orleans. Blood 2013;122:abstract 1937
-
(2013)
Blood
, vol.122
-
-
Berdeja, J.G.1
Savona, M.2
Mace, J.R.3
-
60
-
-
84911112336
-
Phase I study of carfilzomib, lenalidomide, vorinostat and dexamethasone (QUAD) in relapsed +/- refractory multiple myeloma
-
abstract 8535. Presented at
-
Vesole DH, Bilotti E, Richter JR, et al. Phase I study of carfilzomib, lenalidomide, vorinostat and dexamethasone (QUAD) in relapsed +/- refractory multiple myeloma [abstract 8535]. Presented at: annual Meeting of the American Society of Clinical Oncology (ASCO); May 30 - June 3 2014; Chicago, Illinois
-
Annual Meeting of the American Society of Clinical Oncology (ASCO); May 30 - June 3 2014; Chicago, Illinois
-
-
Vesole, D.H.1
Bilotti, E.2
Richter, J.R.3
-
61
-
-
84911112335
-
Prolonged survival and improved response rates with ARRY-520 in relapsed/refractory multiple myeloma (RRMM) patients with low α-1 acid glycoprotein (AAG) levels: Results from a phase 2 study
-
abstract 285. Presented at
-
Lonial S, Shah JJ, Zonder J, et al. Prolonged survival and improved response rates with ARRY-520 in relapsed/refractory multiple myeloma (RRMM) patients with low α-1 acid glycoprotein (AAG) levels: results from a phase 2 study [abstract 285]. Presented at: 55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
-
Lonial, S.1
Shah, J.J.2
Zonder, J.3
-
62
-
-
84911112334
-
Combination of the KSP inhibitor ARRY-520 with bortezomib or revlimid causes sustained tumor regressions and significantly increased time to regrowth in models of multiple myeloma
-
abstract 2858. Presented at
-
Woessner R, Tunquist B, Cox A, et al. Combination of the KSP inhibitor ARRY-520 with bortezomib or revlimid causes sustained tumor regressions and significantly increased time to regrowth in models of multiple myeloma [abstract 2858]. Presented at: 51st Annual Meeting of the American Society of Hematology (ASH); 5-8 December 2013; New Orleans, Louisiana; 2009
-
(2009)
51st Annual Meeting of the American Society of Hematology (ASH); 5-8 December 2013; New Orleans, Louisiana
-
-
Woessner, R.1
Tunquist, B.2
Cox, A.3
-
63
-
-
84911112333
-
Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 (filanesib) + carfilzomib (car) in patients with relapsed and/or refractory multiple myeloma (RRMM)
-
abstract 1982. Presented at
-
Shah JJ, Feng L, Thomas S, et al. Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 (filanesib) + carfilzomib (car) in patients with relapsed and/or refractory multiple myeloma (RRMM) [abstract 1982]. Presented at: 55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
-
Shah, J.J.1
Feng, L.2
Thomas, S.3
-
64
-
-
77956457402
-
Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma
-
Gay F, Rajkumar SV, Coleman M, et al. Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma. Am J Hematol 2010;85:664-9
-
(2010)
Am J Hematol
, vol.85
, pp. 664-669
-
-
Gay, F.1
Rajkumar, S.V.2
Coleman, M.3
-
65
-
-
84906046480
-
Car-bird [carfilzomib, clarithromycin (biaxin®), lenalidomide/(revlimid®), dexamethasone for newly-diagnosed multiple myeloma
-
abstract 3216
-
Mark TM, Allan JN, Marano G, et al. Car-bird [carfilzomib, clarithromycin (biaxin®), lenalidomide/(revlimid®), dexamethasone) for newly-diagnosed multiple myeloma. Blood 2013;122:abstract 3216
-
(2013)
Blood
, vol.122
-
-
Mark, T.M.1
Allan, J.N.2
Marano, G.3
-
66
-
-
84865333050
-
A phase 1/2 study of carfilzomib in combination with lenalidomide and lowdose dexamethasone as a frontline treatment for multiple myeloma
-
Jakubowiak AJ, Dytfeld D, Griffith KA, et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and lowdose dexamethasone as a frontline treatment for multiple myeloma. Blood 2012;120:1801-9
-
(2012)
Blood
, vol.120
, pp. 1801-1809
-
-
Jakubowiak, A.J.1
Dytfeld, D.2
Griffith, K.A.3
-
68
-
-
84905721292
-
Dose escalation phase 2 trial of carfilzomib combined with thalidomide and low-dose dexamethasone in newly diagnosed, transplant eligible patients with multiple myeloma. A trial of the european myeloma network
-
abstract 688
-
Sonneveld P, Asselberg-Hacker E, Zweegman S, et al. Dose escalation phase 2 trial of carfilzomib combined with thalidomide and low-dose dexamethasone in newly diagnosed, transplant eligible patients with multiple myeloma. A trial of the european myeloma network. Blood 2013;122:abstract 688
-
(2013)
Blood
, vol.122
-
-
Sonneveld, P.1
Asselberg-Hacker, E.2
Zweegman, S.3
-
69
-
-
78650993336
-
Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial
-
Palumbo A, Bringhen S, Rossi D, et al. Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial. J Clin Oncol 2010;28:5101-9
-
(2010)
J Clin Oncol
, vol.28
, pp. 5101-5109
-
-
Palumbo, A.1
Bringhen, S.2
Rossi, D.3
-
70
-
-
84896372437
-
Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: Updated follow-up and improved survival
-
Palumbo A, Bringhen S, Larocca A, et al. Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: updated follow-up and improved survival. J Clin Oncol 2014;32:634-40
-
(2014)
J Clin Oncol
, vol.32
, pp. 634-640
-
-
Palumbo, A.1
Bringhen, S.2
Larocca, A.3
-
71
-
-
84911112331
-
A phase I/II trial of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma: Final results of MTD expansion cohort
-
abstract 3179. Presented at
-
Mikhael J, Reeder C, Libby E, et al. A phase I/II trial of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma: final results of MTD expansion cohort [abstract 3179]. Presented at: 55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
-
Mikhael, J.1
Reeder, C.2
Libby, E.3
-
72
-
-
84911112330
-
Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP) in response rates in elderly patients with newly diagnosed multiple myeloma: Results of a phase I/II trial
-
abstract 1933. Presented at
-
Moreau P, Kolb B, Hulin C, et al. Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP) in response rates in elderly patients with newly diagnosed multiple myeloma: results of a phase I/II trial [abstract 1933]. Presented at: 55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
55th Annual Meeting of the American Society of Hematology (ASH); 7-10 December 2013; New Orleans, Louisiana
-
-
Moreau, P.1
Kolb, B.2
Hulin, C.3
-
73
-
-
80051557449
-
Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation
-
Morgan GJ, Davies FE, Gregory WM, et al. NCRI Haematological Oncology Study Group. Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation. Blood 2011;118:1231-8
-
(2011)
Blood
, vol.118
, pp. 1231-1238
-
-
Morgan, G.J.1
Davies, F.E.2
Gregory, W.M.3
-
74
-
-
84860907057
-
Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
-
Kumar S, Flinn I, Richardson PG, et al. Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma. Blood 2012;119:4375-82
-
(2012)
Blood
, vol.119
, pp. 4375-4382
-
-
Kumar, S.1
Flinn, I.2
Richardson, P.G.3
-
75
-
-
84903954700
-
Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: A multicenter, phase 2 study
-
Bringhen S, Petrucci MT, Larocca A, et al. Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study. Blood 2014;124:63-9
-
(2014)
Blood
, vol.124
, pp. 63-69
-
-
Bringhen, S.1
Petrucci, M.T.2
Larocca, A.3
-
76
-
-
84887007753
-
Integrated safety profile of single-agent carfilzomib: Experience from 526 patients enrolled in 4 phase II clinical studies
-
Siegel D, Martin T, Nooka A, et al. Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies. Haematologica 2013;98:1753-61
-
(2013)
Haematologica
, vol.98
, pp. 1753-1761
-
-
Siegel, D.1
Martin, T.2
Nooka, A.3
-
77
-
-
76549137222
-
Peripheral neuropathy and new treatments for multiple myeloma: Background and practical recommendations
-
Mohty B, El-Cheikh J, Yakoub-Agha I, et al. Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations. Haematologica 2010;95:311-19
-
(2010)
Haematologica
, vol.95
, pp. 311-319
-
-
Mohty, B.1
El-Cheikh, J.2
Yakoub-Agha, I.3
-
78
-
-
84859632261
-
Management of treatment-emergent peripheral neuropathy in multiple myeloma
-
Richardson PG, Delforge M, Beksac M, et al. Management of treatment-emergent peripheral neuropathy in multiple myeloma. Leukemia 2012;26:595-608
-
(2012)
Leukemia
, vol.26
, pp. 595-608
-
-
Richardson, P.G.1
Delforge, M.2
Beksac, M.3
-
79
-
-
84893632212
-
Peripheral neuropathy experience in patients with relapsed and/or refractory multiple myeloma treated with carfilzomib
-
Martin TG. Peripheral neuropathy experience in patients with relapsed and/or refractory multiple myeloma treated with carfilzomib. Oncology 2013;27(Suppl 3):4-10
-
(2013)
Oncology
, vol.27
, pp. 4-10
-
-
Martin, T.G.1
-
80
-
-
84893623300
-
Incidence and management of renal adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib
-
Shah JJ. Incidence and management of renal adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib. Oncology 2013;27(Suppl 3):19-23
-
(2013)
Oncology
, vol.27
, pp. 19-23
-
-
Shah, J.J.1
-
81
-
-
84893525762
-
Overview and management of cardiac and pulmonary adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib
-
Wang M, Cheng J. Overview and management of cardiac and pulmonary adverse events in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib. Oncology 2013;27(Suppl 3):24-30
-
(2013)
Oncology
, vol.27
, pp. 24-30
-
-
Wang, M.1
Cheng, J.2
-
82
-
-
84893289668
-
Clinical profile of once-daily, modified-release oprozomib tablets in patients with hematologic malignancies: Results of a phase 1b/2 trial
-
abstract P233
-
Kaufman J, Siegel D, Vij R, et al. Clinical profile of once-daily, modified-release oprozomib tablets in patients with hematologic malignancies: results of a phase 1b/2 trial. Haematologica 2013;98(Suppl 1):abstract P233
-
(2013)
Haematologica
, vol.98
-
-
Kaufman, J.1
Siegel, D.2
Vij, R.3
-
83
-
-
84906056010
-
Clinical profile of single-agent modified-release oprozomib tablets in patients (pts) with hematologic malignancies: Updated results from a multicenter, open-label, dose escalation phase 1b/2 study
-
abstract 3184
-
Ghobrial IM, Kaufman JL, Siegel DS, et al. Clinical profile of single-agent modified-release oprozomib tablets in patients (pts) with hematologic malignancies: updated results from a multicenter, open-label, dose escalation phase 1b/2 study. Blood 2013;122:abstract 3184
-
(2013)
Blood
, vol.122
-
-
Ghobrial, I.M.1
Kaufman, J.L.2
Siegel, D.S.3
-
84
-
-
84906046478
-
Phase 2 trial of single agent MLN9708 in patients with relapsed multiple myeloma not refractory to bortezomib
-
abstract 1944
-
Kumar SK, Roy V, Reeder C, et al. Phase 2 trial of single agent MLN9708 in patients with relapsed multiple myeloma not refractory to bortezomib. Blood 2013;122:abstract 1944
-
(2013)
Blood
, vol.122
-
-
Kumar, S.K.1
Roy, V.2
Reeder, C.3
-
85
-
-
84911112329
-
Weekly oral investigational proteasome inhibitor MLN9708 plus lenalidomide-dexamethasone in elderly patients (pts) with previously untreated multiple myeloma (mm): Subset analysis of a phase 1/2 study
-
abstract P236
-
Richardson P, Berdeja JG, Niesvizy R, et al. Weekly oral investigational proteasome inhibitor MLN9708 plus lenalidomide-dexamethasone in elderly patients (pts) with previously untreated multiple myeloma (mm): subset analysis of a phase 1/2 study. Haematologica 2013;98(Suppl 1):abstract P236
-
(2013)
Haematologica
, vol.98
-
-
Richardson, P.1
Berdeja, J.G.2
Niesvizy, R.3
-
86
-
-
84897426210
-
Twice-weekly oral MLN9708 (ixazomib citrate), an investigational proteasome inhibitor, in combination with lenalidomide (Len) and dexamethasone (dex) in patients (pts) with newly diagnosed multiple myeloma (mm): Final phase 1 results and phase 2 data
-
abstract 535
-
Richardson PG, Hofmeister CC, Rosenbaum CA, et al. Twice-weekly oral MLN9708 (ixazomib citrate), an investigational proteasome inhibitor, in combination with lenalidomide (Len) and dexamethasone (dex) in patients (pts) with newly diagnosed multiple myeloma (mm): final phase 1 results and phase 2 data. Blood 2013;122:abstract 535
-
(2013)
Blood
, vol.122
-
-
Richardson, P.G.1
Hofmeister, C.C.2
Rosenbaum, C.A.3
-
87
-
-
84906056304
-
Phase II study of the combination of MLN 9708 with lenalidomide as maintenance therapy post autologous stem cell transplant in patients with multiple myeloma
-
abstract 1983
-
Shah JJ, Baladandayuthapani V, Weber DM, et al. Phase II study of the combination of MLN 9708 with lenalidomide as maintenance therapy post autologous stem cell transplant in patients with multiple myeloma. Blood 2013;122:abstract 1983
-
(2013)
Blood
, vol.122
-
-
Shah, J.J.1
Baladandayuthapani, V.2
Weber, D.M.3
-
88
-
-
84896527916
-
Elotuzumab and daratumumab: Emerging new monoclonal antibodies for multiple myeloma
-
Kuroda J, Nagoshi H, Shimura Y, et al. Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma. Expert Rev Anticancer Ther 2013;13:1081-8
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, pp. 1081-1088
-
-
Kuroda, J.1
Nagoshi, H.2
Shimura, Y.3
-
89
-
-
84911112328
-
A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma
-
abstract 8532
-
Martin TG, Hsu K, Strickland SA, et al. A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma. J Clin Oncol 2014;32:abstract 8532
-
(2014)
J Clin Oncol
, vol.32
-
-
Martin, T.G.1
Hsu, K.2
Strickland, S.A.3
-
90
-
-
84904759333
-
Proteasome inhibitors - Molecular basis and current perspectives in multiple myeloma
-
Kubiczkova L, Pour L, Sedlarikova L, et al. Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma. J Cell Mol Med 2014;18:947-61
-
(2014)
J Cell Mol Med
, vol.18
, pp. 947-961
-
-
Kubiczkova, L.1
Pour, L.2
Sedlarikova, L.3
-
91
-
-
84890552098
-
New orally active proteasome inhibitors in multiple myeloma
-
Allegra A, Alonci A, Gerace D, et al. New orally active proteasome inhibitors in multiple myeloma. Leuk Res 2014;38:1-9
-
(2014)
Leuk Res
, vol.38
, pp. 1-9
-
-
Allegra, A.1
Alonci, A.2
Gerace, D.3
-
93
-
-
84887967953
-
Elotuzumab: A novel anti- CS1 monoclonal antibody for the treatment of multiple myeloma
-
Lonial S, Kaufman J, Laubach J, Richardson P. Elotuzumab: a novel anti- CS1 monoclonal antibody for the treatment of multiple myeloma. Expert Opin Biol Ther 2013;13:1731-40
-
(2013)
Expert Opin Biol Ther
, vol.13
, pp. 1731-1740
-
-
Lonial, S.1
Kaufman, J.2
Laubach, J.3
Richardson, P.4
-
94
-
-
33747586073
-
Ubiquitylation in normal and malignant hematopoiesis: Novel therapeutic targets
-
Marteijn JAF, Jansen JH, van der Reijden BA. Ubiquitylation in normal and malignant hematopoiesis: novel therapeutic targets. Leukemia 2006;20:1511-18
-
(2006)
Leukemia
, vol.20
, pp. 1511-1518
-
-
Marteijn, J.A.F.1
Jansen, J.H.2
Van Der Reijden, B.A.3
-
95
-
-
54949112715
-
-
Advanced Chemistry Development, Inc, Toronto, ON, Canada; Available from
-
ACD/ChemSketch Freeware. Advanced Chemistry Development, Inc, Toronto, ON, Canada; 2014. Available from: www.acdlabs.com
-
(2014)
ACD/ChemSketch Freeware
-
-
|