메뉴 건너뛰기




Volumn 36, Issue 11, 2012, Pages 1422-1427

CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma

Author keywords

Delanzomib; Dexamethasone; In vivo; Inhibitors; Lenalidomide; Multiple myeloma; Proteasome

Indexed keywords

DELANZOMIB; DEXAMETHASONE; IMMUNOGLOBULIN G; LENALIDOMIDE;

EID: 84866341173     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.07.018     Document Type: Article
Times cited : (25)

References (49)
  • 1
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T., Chauhan D., Shima Y., Raje N., Davies F.E., Tai Y.T., et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000, 96:2943-2950.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3    Raje, N.4    Davies, F.E.5    Tai, Y.T.6
  • 2
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies F.E., Raje N., Hideshima T., Lentzsch S., Young G., Tai Y.T., et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001, 98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3    Lentzsch, S.4    Young, G.5    Tai, Y.T.6
  • 3
    • 0000747276 scopus 로고    scopus 로고
    • Thalidomide with dexamethasone for resistant multiple myeloma
    • [abstract]
    • Weber D.M., Rankin K., Gavino M., Delasalle K., Alexanian R. Thalidomide with dexamethasone for resistant multiple myeloma. Blood 2000, 96:167a. [abstract].
    • (2000) Blood , vol.96
    • Weber, D.M.1    Rankin, K.2    Gavino, M.3    Delasalle, K.4    Alexanian, R.5
  • 4
    • 0036843032 scopus 로고    scopus 로고
    • Combination therapy with thalidomide plus dexamethasone for newly diagnosed multiple myeloma
    • Rajkumar S.V., Hayman S.R., Gertz M.A., Dispenzieri A., Lacy M.Q., Greipp P.R., et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed multiple myeloma. J Clin Oncol 2002, 20:4319-4323.
    • (2002) J Clin Oncol , vol.20 , pp. 4319-4323
    • Rajkumar, S.V.1    Hayman, S.R.2    Gertz, M.A.3    Dispenzieri, A.4    Lacy, M.Q.5    Greipp, P.R.6
  • 5
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson P.G., Schlossman R.L., Weller E., Hideshima T., Mitsiades C., Davies F., et al. Immunomodulatory drug CC5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3    Hideshima, T.4    Mitsiades, C.5    Davies, F.6
  • 6
    • 27744492561 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
    • Rajkumar S.V., Hayman S.R., Lacy M.Q., Dispenzieri A., Geyer S.M., Kabat B., et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005, 106:4050-4053.
    • (2005) Blood , vol.106 , pp. 4050-4053
    • Rajkumar, S.V.1    Hayman, S.R.2    Lacy, M.Q.3    Dispenzieri, A.4    Geyer, S.M.5    Kabat, B.6
  • 7
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group
    • Rajkumar S.V., Blood E., Vesole D.H., Fonseca R., Greipp P.R. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006, 24:431-436.
    • (2006) J Clin Oncol , vol.24 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.H.3    Fonseca, R.4    Greipp, P.R.5
  • 8
    • 43749117945 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
    • Rajkumar S.V., Rosinol L., Hussein M., Catalano J., Jedrzejczak W., Lucy L., et al. Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J Clin Oncol 2008, 26:2171-2177.
    • (2008) J Clin Oncol , vol.26 , pp. 2171-2177
    • Rajkumar, S.V.1    Rosinol, L.2    Hussein, M.3    Catalano, J.4    Jedrzejczak, W.5    Lucy, L.6
  • 9
    • 34548314992 scopus 로고    scopus 로고
    • A randomized phase III trial of lenalidomide plus high-dose dexamethasone vs lenalidomide plus low dose dexamethasone in newly diagnosed multiple myeloma (E4A03): a trial coordinated by the Eastern Cooperative Oncology Group
    • [abstract]
    • Rajkumar S.V., Jacobus S., Callander N., Fonseca R., Vesole D., Greipp P. A randomized phase III trial of lenalidomide plus high-dose dexamethasone vs lenalidomide plus low dose dexamethasone in newly diagnosed multiple myeloma (E4A03): a trial coordinated by the Eastern Cooperative Oncology Group. Blood 2006, 108:799. [abstract].
    • (2006) Blood , vol.108 , pp. 799
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.3    Fonseca, R.4    Vesole, D.5    Greipp, P.6
  • 10
    • 34848824393 scopus 로고    scopus 로고
    • Long term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma
    • Lacy M.Q., Gertz M.A., Dispenzieri A., Hayman S.R., Geyer S., Kabat B., et al. Long term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma. Mayo Clin Proc 2007, 82:1179-1184.
    • (2007) Mayo Clin Proc , vol.82 , pp. 1179-1184
    • Lacy, M.Q.1    Gertz, M.A.2    Dispenzieri, A.3    Hayman, S.R.4    Geyer, S.5    Kabat, B.6
  • 11
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma M.H., Yang H.H., Parker K., Manyak S., Friedman J.M., Altamirano C., et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003, 9:1136-1144.
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3    Manyak, S.4    Friedman, J.M.5    Altamirano, C.6
  • 12
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T., Richardson P., Chauhan D., Palombella V.J., Elliott P.J., Adams J., et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001, 61:3071-3076.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6
  • 13
    • 21344469223 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
    • Jagannath S., Durie B.G., Wolf J., Camacho E., Irwin D., Lutzky J., et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005, 129:776-783.
    • (2005) Br J Haematol , vol.129 , pp. 776-783
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.3    Camacho, E.4    Irwin, D.5    Lutzky, J.6
  • 14
    • 33750953054 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study
    • Harousseau J.L., Attal M., Leleu X., Troncy J., Pegourie B., Stoppa A.M., et al. Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study. Haematologica 2006, 91:1498-1505.
    • (2006) Haematologica , vol.91 , pp. 1498-1505
    • Harousseau, J.L.1    Attal, M.2    Leleu, X.3    Troncy, J.4    Pegourie, B.5    Stoppa, A.M.6
  • 16
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson P.G., Weller E., Jagannath S., Avigan D.E., Alsina M., Schlossman R., et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009, 27:5713-5719.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3    Avigan, D.E.4    Alsina, M.5    Schlossman, R.6
  • 17
    • 0028775544 scopus 로고
    • Treatment of multiple myeloma
    • Alexanian R., Dimopoulos M. Treatment of multiple myeloma. N Engl J Med 1994, 330:484-489.
    • (1994) N Engl J Med , vol.330 , pp. 484-489
    • Alexanian, R.1    Dimopoulos, M.2
  • 18
    • 75149157969 scopus 로고    scopus 로고
    • The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan
    • Sanchez E., Li M., Steinberg J.A., Wang C., Shen J., Bonavida B., et al. The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan. Br J Haematol 2010, 148:569-581.
    • (2010) Br J Haematol , vol.148 , pp. 569-581
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3    Wang, C.4    Shen, J.5    Bonavida, B.6
  • 19
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson P.G., Weller E., Lonial S., Jakubowiak A.J., Jagannath S., Raje N.S., et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010, 116:679-686.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3    Jakubowiak, A.J.4    Jagannath, S.5    Raje, N.S.6
  • 20
    • 57349195605 scopus 로고    scopus 로고
    • Animal models of multiple myeloma and their utility in drug discovery
    • John Wiley & Sons, Inc., Hoboken, JN, Unite 14.9
    • Campbell R.A., Berenson J.R. Animal models of multiple myeloma and their utility in drug discovery. Current protocols in pharmacology 2008, vol. 40. John Wiley & Sons, Inc., Hoboken, JN, Unite 14.9, p. 14.9.1-14.9.22.
    • (2008) Current protocols in pharmacology , vol.40 , pp. 1491-14922
    • Campbell, R.A.1    Berenson, J.R.2
  • 21
    • 0026425674 scopus 로고
    • Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue
    • Bissery M.-C., Guenard D., Gueritte-Voeglein F., Lavelle F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res 1991, 51:4845-4852.
    • (1991) Cancer Res , vol.51 , pp. 4845-4852
    • Bissery, M.-C.1    Guenard, D.2    Gueritte-Voeglein, F.3    Lavelle, F.4
  • 23
    • 77955714026 scopus 로고    scopus 로고
    • Primary therapy with single agent bortezomib as induction, maintenance and re-induction in patients with high-risk myeloma: results of the ECOG E2A02 trial
    • Dispenzieri A., Jacobus S., Vesole D.H., Callandar N., Fonseca R., Greipp P.R. Primary therapy with single agent bortezomib as induction, maintenance and re-induction in patients with high-risk myeloma: results of the ECOG E2A02 trial. Leukemia 2010, 24:1406-1411.
    • (2010) Leukemia , vol.24 , pp. 1406-1411
    • Dispenzieri, A.1    Jacobus, S.2    Vesole, D.H.3    Callandar, N.4    Fonseca, R.5    Greipp, P.R.6
  • 24
    • 41949110089 scopus 로고    scopus 로고
    • CEP-18770: a novel orally-active proteasome inhibitor with a tumor-selective pharmacological profile competitive with bortezomib
    • Piva R., Ruggeri B., Williams M., Costa G., Tamagno I., Ferrero D., et al. CEP-18770: a novel orally-active proteasome inhibitor with a tumor-selective pharmacological profile competitive with bortezomib. Blood 2008, 111:2765-2775.
    • (2008) Blood , vol.111 , pp. 2765-2775
    • Piva, R.1    Ruggeri, B.2    Williams, M.3    Costa, G.4    Tamagno, I.5    Ferrero, D.6
  • 25
    • 39749143840 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
    • Dorsey B.D., Iqbal M., Chatterjee S., Menta E., Bernardini R., Bernareggi A., et al. Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem 2008, 51:1068-1072.
    • (2008) J Med Chem , vol.51 , pp. 1068-1072
    • Dorsey, B.D.1    Iqbal, M.2    Chatterjee, S.3    Menta, E.4    Bernardini, R.5    Bernareggi, A.6
  • 26
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy
    • Dick L.R., Fleming P.E. Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today 2010, 15:243-249.
    • (2010) Drug Discov Today , vol.15 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 27
    • 77949315484 scopus 로고    scopus 로고
    • Combination of novel proteasome inhibitor NPI-0052 and lenaliomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D., Singh A.V., Ciccarelli B., Richardson P.G., Palladino M.A., Anderson K.C. Combination of novel proteasome inhibitor NPI-0052 and lenaliomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood 2010, 115:834-844.
    • (2010) Blood , vol.115 , pp. 834-844
    • Chauhan, D.1    Singh, A.V.2    Ciccarelli, B.3    Richardson, P.G.4    Palladino, M.A.5    Anderson, K.C.6
  • 28
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D., Singh A.V., Aujay M., Kirk C.J., Bandi M., Ciccarelli B., et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 2010, 116:4906-4915.
    • (2010) Blood , vol.116 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3    Kirk, C.J.4    Bandi, M.5    Ciccarelli, B.6
  • 29
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    • Chauhan D., Tian Z., Zhou B., Kuhn D., Orlowski R., Raje N., et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 2011, 17:5311-5321.
    • (2011) Clin Cancer Res , vol.17 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3    Kuhn, D.4    Orlowski, R.5    Raje, N.6
  • 30
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn D.J., Chen Q., Voorhees P.M., Strader J.S., Shenk K.D., Sun C.M., et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007, 110:3281-3290.
    • (2007) Blood , vol.110 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3    Strader, J.S.4    Shenk, K.D.5    Sun, C.M.6
  • 32
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
    • Chauhan D., Catley L., Li G., Podar K., Hideshima T., Velankar M., et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 2005, 8:407-419.
    • (2005) Cancer Cell , vol.8 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3    Podar, K.4    Hideshima, T.5    Velankar, M.6
  • 33
    • 38949125853 scopus 로고    scopus 로고
    • Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D., Singh A.V., Brahmandam M., Podar K., Hideshima T., Richardson P., et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008, 111:1654-1664.
    • (2008) Blood , vol.111 , pp. 1654-1664
    • Chauhan, D.1    Singh, A.V.2    Brahmandam, M.3    Podar, K.4    Hideshima, T.5    Richardson, P.6
  • 34
    • 70349643684 scopus 로고    scopus 로고
    • Final results of PX-171-003-A0, part 1 of an open-label, single arm, phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma
    • [abstract]
    • Jagannath S., Vij K., Stewart K. Final results of PX-171-003-A0, part 1 of an open-label, single arm, phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma. J Clin Oncol 2009, 27(15s):8504. [abstract].
    • (2009) J Clin Oncol , vol.27 , Issue.15 S , pp. 8504
    • Jagannath, S.1    Vij, K.2    Stewart, K.3
  • 35
    • 84866311322 scopus 로고    scopus 로고
    • A phase I/II study of carfilzomib (CFZ) as a replacement for bortezomib (BTZ) for multiple myeloma (MM) patients (Pts) progressing while receiving a BTZ-containing combination regimen
    • [abstract]
    • Berenson J.R., Yellin O., Dichmann R., Patel-Donnelly D., Boccia R.V., Hilger J.D., et al. A phase I/II study of carfilzomib (CFZ) as a replacement for bortezomib (BTZ) for multiple myeloma (MM) patients (Pts) progressing while receiving a BTZ-containing combination regimen. J Clin Oncol 2012, 30:8098. [abstract].
    • (2012) J Clin Oncol , vol.30 , pp. 8098
    • Berenson, J.R.1    Yellin, O.2    Dichmann, R.3    Patel-Donnelly, D.4    Boccia, R.V.5    Hilger, J.D.6
  • 36
  • 38
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
    • Mitsiades N., Mitsiades C.S., Poulaki V., Chauhan D., Richardson P.G., Hideshima T., et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002, 99:4525-4530.
    • (2002) Blood , vol.99 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3    Chauhan, D.4    Richardson, P.G.5    Hideshima, T.6
  • 39
    • 34447299646 scopus 로고    scopus 로고
    • Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid
    • Campbell R.A., Sanchez E., Steinberg J.A., Baritaki S., Gordon M., Wang C., et al. Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid. Br J Haematol 2007, 138:467-478.
    • (2007) Br J Haematol , vol.138 , pp. 467-478
    • Campbell, R.A.1    Sanchez, E.2    Steinberg, J.A.3    Baritaki, S.4    Gordon, M.5    Wang, C.6
  • 40
    • 33846914141 scopus 로고    scopus 로고
    • Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
    • Podar K., Raab M.S., Zhang J., McMillin D., Breitkreutz I., Tai Y.T., et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood 2007, 109:1669-1677.
    • (2007) Blood , vol.109 , pp. 1669-1677
    • Podar, K.1    Raab, M.S.2    Zhang, J.3    McMillin, D.4    Breitkreutz, I.5    Tai, Y.T.6
  • 41
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
    • Pei X.Y., Dai Y., Grant S. Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin Cancer Res 2004, 10:3839-3852.
    • (2004) Clin Cancer Res , vol.10 , pp. 3839-3852
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 42
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications
    • Mitsiades N., Mitsiades C.S., Richardson P.G., Poulaki V., Yu-Tzu T., Chauhan D., et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003, 101:2377-2380.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3    Poulaki, V.4    Yu-Tzu, T.5    Chauhan, D.6
  • 44
    • 79960208716 scopus 로고    scopus 로고
    • Novel proteasome inhibitors to overcome bortezomib resistance
    • Ruschak A.M., Slassi M., Kay L.E., Schimmer A.D. Novel proteasome inhibitors to overcome bortezomib resistance. J Natl Cancer Inst 2011, 103:1007-1017.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1007-1017
    • Ruschak, A.M.1    Slassi, M.2    Kay, L.E.3    Schimmer, A.D.4
  • 46
    • 33644916110 scopus 로고    scopus 로고
    • Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson J.R., Yang H.H., Sadler K., Jarutirasarn S.G., Vescio R.A., Mapes R., et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 2006, 24:937-944.
    • (2006) J Clin Oncol , vol.24 , pp. 937-944
    • Berenson, J.R.1    Yang, H.H.2    Sadler, K.3    Jarutirasarn, S.G.4    Vescio, R.A.5    Mapes, R.6
  • 48
    • 46949091076 scopus 로고    scopus 로고
    • Safety and efficacy of bortezomib and melphalan combination in patients with relapsed or refractory multiple myeloma: updated results of a phase 1/2 study after longer follow-up
    • Berenson J.R., Yang H.H., Vescio R.A., Nassir Y., Mapes R., Lee S.P., et al. Safety and efficacy of bortezomib and melphalan combination in patients with relapsed or refractory multiple myeloma: updated results of a phase 1/2 study after longer follow-up. Ann Hematol 2008, 87:623-631.
    • (2008) Ann Hematol , vol.87 , pp. 623-631
    • Berenson, J.R.1    Yang, H.H.2    Vescio, R.A.3    Nassir, Y.4    Mapes, R.5    Lee, S.P.6
  • 49
    • 47549115250 scopus 로고    scopus 로고
    • VTD combination therapy with bortezomib-thalidomide-dexamethasone is highly effective in advanced and refractory multiple myeloma
    • Pineda-Roman M., Zangari M., van Rhee F., Anaissie E., Szymonifka J., Hoering A., et al. VTD combination therapy with bortezomib-thalidomide-dexamethasone is highly effective in advanced and refractory multiple myeloma. Leukemia 2008, 22:1419-1427.
    • (2008) Leukemia , vol.22 , pp. 1419-1427
    • Pineda-Roman, M.1    Zangari, M.2    van Rhee, F.3    Anaissie, E.4    Szymonifka, J.5    Hoering, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.