Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis

Toxicology Letters

Volumn 232, Issue 1, 2015, Pages 213-220

  Zhao, Hui ^a   Qin, Hou Ying ^a   Cao, Lin Feng ^a   Chen, Yuan Hua ^a   Tan, Zhu Xia ^a   Zhang, Cheng ^a   Xu, De Xiang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Bleomycin; Endoplasmic reticulum stress; Epithelial mesenchymal transition; Phenylbutyric acid; Unfolded protein response

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; BUTYRIC ACID DERIVATIVE; COLLAGEN 1ALPHA1; COLLAGEN 1ALPHA2; COLLAGEN TYPE 1; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PHENYLBUTYRIC ACID; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACTA2 PROTEIN, MOUSE; ACTIN; ALPHA 2(I) COLLAGEN; ARYLBUTYRIC ACID DERIVATIVE; COLLAGEN TYPE I, ALPHA 1 CHAIN; PROTECTIVE AGENT; RELA PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; MOUSE; NONHUMAN; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; CELL PROTECTION; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; LUNG; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BLEOMYCIN; COLLAGEN TYPE I; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; LUNG; MICE; PHENYLBUTYRATES; PROTECTIVE AGENTS; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; UNFOLDED PROTEIN RESPONSE;

EID: 84911164083     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.10.013     Document Type: Article

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