Global geno-proteomic analysis reveals cross-continental sequence conservation and druggable sites among influenza virus polymerases

Antiviral Research

Volumn 112, Issue , 2014, Pages 120-131

  Babar, Mustafeez Mujtaba ^a   Zaidi, Najam Us Sahar Sadaf ^a   Tahir, Muhammad ^a  

^a NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

Author keywords

Drug targets; Geotemporal sequence conservation; Influenza polymerases; Influenza protein druggability; Influenza virus

Indexed keywords

AMINO ACID; INFLUENZA VIRUS POLYMERASE; NUCLEOTIDE; PA PROTEIN; PA X PROTEIN; PB1 F2 PROTEIN; PB1 PROTEIN; PB2 PROTEIN; PROTEOME; UNCLASSIFIED DRUG; VIRUS PROTEIN; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE;

AMINO ACID SEQUENCE; ANTIVIRAL THERAPY; ARTICLE; DRUG BINDING; DRUG BINDING SITE; DRUG TARGETING; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INFLUENZA VIRUS; MATHEMATICAL ANALYSIS; META ANALYSIS (TOPIC); METABOLIC DISORDER; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN TARGETING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; STRUCTURAL GENE; VIRUS GENOME; BIOLOGY; CHEMISTRY; DNA SEQUENCE; ENZYMOLOGY; GENETICS; META ANALYSIS; ORTHOMYXOVIRIDAE; PHYLOGEOGRAPHY; PROTEIN CONFORMATION;

LONCHOCARPUS GLAUCIFOLIUS; ORTHOMYXOVIRIDAE;

COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; ORTHOMYXOVIRIDAE; PHYLOGEOGRAPHY; PROTEIN CONFORMATION; RNA REPLICASE; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, PROTEIN; VIRAL PROTEINS;

EID: 84911124700     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.10.013     Document Type: Article

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