Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β

International Journal of Cancer

Volumn 136, Issue 3, 2015, Pages 572-583

  Andzinski, Lisa ^a   Wu, Ching Fang ^a   Lienenklaus, Stefan ^a   Kröger, Andrea ^a   Weiss, Siegfried ^a   Jablonska, Jadwiga ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Apoptosis; G CSF; IFN ; Neutrophils; Tumor

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BETA INTERFERON; CASPASE 10; CASPASE 3; CASPASE 9; CD11B ANTIGEN; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; CASPASE; FAS PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; IMMUNOSURVEILLANCE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR ASSOCIATED LEUKOCYTE; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CYTOLOGY; IMMUNOLOGY; METABOLISM; NEOPLASM; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASES; CELL LINE, TUMOR; GRANULOCYTE COLONY-STIMULATING FACTOR; INTERFERON-BETA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS; NEUTROPHILS; REACTIVE OXYGEN SPECIES;

EID: 84911006494     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28957     Document Type: Article

References (50)

1. Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006;6:173-82.
2. Tazawa H, Okada F, Kobayashi T, et al. Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammationassociated carcinogenesis and tumor progression. Am J Pathol 2003;163:2221-32.
3. Shojaei F, Singh M, Thompson JD, et al. Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci USA 2008;105:2640-5.
4. Jablonska J, Leschner S, Westphal K, et al. Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest 2010;120:1151-64.
5. Schmielau J, Finn OJ. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 2001;61:4756-60.
6. Segal AW. How neutrophils kill microbes. Annu Rev Immunol 2005;23:197-223.
7. Amulic B, Cazalet C, Hayes GL, et al. Neutrophil Function: From Mechanisms to Disease. 2012;30: 459-89.
8. Gabelloni ML, Trevani AS, Sabatté J, Geffner J. Mechanisms regulating neutrophil survival and cell death. Semin Immunopathol, 2013;35:423-37. doi:10.1007/s00281-013-0364-x.
9. Gough DJ, Messina NL, Clarke CJP, et al. Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 2012; 36:166-74.
10. Honda K, Mizutani T, Taniguchi T. Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. Proc Natl Acad Sci USA 2004;101:2416-21.
11. Deonarain R, Verma A, Porter AC, et al. Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha. Proc Natl Acad Sci USA 2003;100:13453-8.
12. Yen J-H, Ganea D. Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation. Blood 2009;114:1344-54.
13. Herbeuval J-P, Grivel J-C, Boasso A, et al. CD41 T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 2005;106: 3524-31.
14. Kalvakolanu DV. Interferons and cell growth control. Histol Histopathol 2000;15: 523-37.
15. Brierley MM, Fish EN. Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry. J Interferon Cytokine Res 2002;22:835-45.
16. Wang BX, Rahbar R, Fish EN. Interferon: current status and future prospects in cancer therapy. J Interf Cytokine Res 2011;31:545-52.
17. Lenci RE, Bevier M, Brandt A, et al. Influence of genetic variants in type I interferon genes on melanoma survival and therapy. PLoS One 2012; 7:e50692.
18. Jonsson H, Allen P, Peng SL. Inflammatory arthritis requires Foxo3a to prevent Fas ligandinduced neutrophil apoptosis. Nat Med 2005;11: 666-71.
19. Safa AR. c-FLIP, a master anti-apoptotic regulator. Exp Oncol 2012;34:176-84.
20. García-Sáez AJ. The secrets of the Bcl-2 family. Cell Death Differ 2012;19:1733-40.
21. Weinmann P, Gaehtgens P, Walzog B. Bcl-Xland Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood 1999; 93:3106-15.
22. Perskvist N, Long M, Stendahl O, et al. Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygendependent pathway. J Immunol 2002;168:6358-65.
23. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-89.
24. Slee EA. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2,-3,-6,-7,-8,and-10in a caspase-9-dependent manner. J Cell Biol 1999;144:281-92.
25. Chang HY, Yang X. Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev 2000;64:821-46.
26. Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012;19:107-20.
27. Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 2008;9:378-90.
28. Fridlender ZG, Sun J, Kim S, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 2009;16:183-94.
29. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012;12:253-68.
30. Dumitru CA, Moses K, Trellakis S, et al. Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology. Cancer Immunol Immunother 2012;61:1155-67.
31. Brandau S, Moses K, Lang S. The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: cousins, siblings or twins? Semin Cancer Biol 2013;23:171-82.
32. Jensen HK, Donskov F, Marcussen N, et al. Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. J Clin Oncol 2009;27:4709-17.
33. Fossati G, Ricevuti G, Edwards SW, et al. Neutrophil infiltration into human gliomas. Acta Neuropathol 1999;98:349-54.
34. Reid MD, Basturk O, Thirabanjasak D, et al. Tumor-infiltrating neutrophils in pancreatic neoplasia. Mod Pathol 2011;24:1612-9.
35. Jablonska J, Wu C-F, Andzinski L, et al. CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-b. Int J Cancer, 2013; 134:1346-58.
36. Kuijpers T, Lutter R. Inflammation and repeated infections in CGD: two sides of a coin. Cell Mol Life Sci 2012;69:7-15.
37. Kasahara Y, Iwai K, Yachie A, et al. Involvement of reactive oxygen intermediates in spontaneous and CD95(Fas/APO-1)-mediated apoptosis of neutrophils. Blood 1997;89:1748-53.
38. Lundqvist-Gustafsson H, Bengtsson T. Activation of the granule pool of the NADPH oxidase accelerates apoptosis in human neutrophils. J Leukoc Biol 1999;65:196-204.
39. Yim HY, Yang Y, Lim J-S, et al. The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-a/ b-mediated apoptosis in Ubp43-deficient hematopoietic cells. Biochem Biophys Res Commun 2012; 423:436-40.
40. Liles WC, Kiener PA, Ledbetter JA, et al. Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med 1996;184:429-40.
41. Fecho K, Bentley SA, Cohen PL. Mice deficient in fas ligand (gld) or fas (lpr) show few alterations in granulopoiesis. Cell Immunol 1998;188:19-32.
42. Chawla-Sarkar M, Leaman DW, Borden EC. Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines. Clin Cancer Res 2001;7:1821-31.
43. Selleri C, Sato T, Del Vecchio L, et al. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood 1997;89:957-64.
44. Gardai SJ, Hildeman DA, Frankel SK, et al. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 2004;279:21085-95.
45. Dibbert B, Weber M, Nikolaizik WH, et al. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci USA 1999;96:13330-5.
46. Murphy BM, O'Neill AJ, Adrain C, et al. The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C. J Exp Med 2003;197:625-32.
47. Im JH, Tapmeier T, Balathasan L, et al. G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. Int J Cancer 2012.
48. Maianski NA, Roos D, Kuijpers TW. Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colonystimulating factor. J Immunol 2004;172:7024-30.
49. Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol 2006;6:836-48.
50. Diamond MS, Kinder M, Matsushita H, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 2011;208:1989-2003.