Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits

Hippocampus

Volumn 24, Issue 12, 2014, Pages 1466-1481

  Gangarossa, Giuseppe ^a,b   Ceolin, Laura ^a,b   Paucard, Alexia ^a,b   Lerner Natoli, Mireille ^a,b   Perroy, Julie ^a,b   Fagni, Laurent ^a,b   Valjent, Emmanuel ^a,b  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b INSERM   (France)

Author keywords

Dopamine D1R; Hippocampus; Memory; MTOR signaling; Seizures

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; DIAZEPAM; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RAPAMYCIN; BENZAZEPINE DERIVATIVE; DOPAMINE RECEPTOR STIMULATING AGENT; MTOR PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; SK&F 81297; TARGET OF RAPAMYCIN KINASE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL AMYGDALA; COGNITION; DENTATE GYRUS; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; ENZYME PHOSPHORYLATION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; LOCOMOTION; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RIBOSOMAL SUBUNIT S6; RIBOSOME SUBUNIT; SIGNAL TRANSDUCTION; SYNAPSE; TONIC CLONIC SEIZURE; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; MEMORY DISORDER; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RECOGNITION; SEIZURES; TISSUE CULTURE TECHNIQUE;

ANIMALS; BENZAZEPINES; CEREBRAL CORTEX; DENTATE GYRUS; DOPAMINE AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LONG-TERM POTENTIATION; MALE; MEMORY DISORDERS; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RECEPTORS, DOPAMINE D1; RECOGNITION (PSYCHOLOGY); SEIZURES; SIGNAL TRANSDUCTION; SIROLIMUS; TISSUE CULTURE TECHNIQUES; TOR SERINE-THREONINE KINASES;

EID: 84911005298     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22327     Document Type: Article

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