Caspase-1/ASC inflammasome-mediated activation of IL-1β-ROS-NF-κB pathway for control of Trypanosoma cruzireplication and survival is dispensable in NLRP3-/- macrophages

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Dey, Nilay ^a   Sinha, Mala ^b   Gupta, Shivali ^a   Gonzalez, Mariela Natacha ^c   Fang, Rong ^a   Endsley, Janice J ^a   Luxon, Bruce A ^b   Garg, Nisha Jain ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c Ciudad Autónoma de Buenos Aires ^*  (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOSKELETON PROTEIN; PYCARD PROTEIN, HUMAN; PYCARD PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE GENE; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; GENE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PARASITE PHENOMENA AND FUNCTIONS; PARASITE REPLICATION; PARASITE SURVIVAL; PROTEIN FUNCTION; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRYPANOSOMA CRUZI; ANIMAL; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; KNOCKOUT MOUSE; METABOLISM; PARASITOLOGY;

TRYPANOSOMA;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CHAGAS DISEASE; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, KNOCKOUT; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRYPANOSOMA CRUZI;

EID: 84910669782     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111539     Document Type: Article

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