메뉴 건너뛰기




Volumn 102, Issue , 2015, Pages 476-493

Detection, identification and quantification by 1H NMR of adulterants in 150 herbal dietary supplements marketed for improving sexual performance

Author keywords

Adulteration; Dietary supplements; Mass spectrometry; NMR; PDE 5 inhibitors

Indexed keywords

CURCUMIN; FLIBANSERIN; HERBACEOUS AGENT; ICARIIN; OSTHOLE; PARACETAMOL; PHENTOLAMINE; PIPERINE; PRASTERONE; SALICIN; SILDENAFIL; TADALAFIL; TESTOSTERONE; VARDENAFIL; YOHIMBINE; APHRODISIACS; HYDROGEN; PHOSPHODIESTERASE 5 INHIBITORS; PLANT PREPARATIONS;

EID: 84910661382     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.10.011     Document Type: Article
Times cited : (96)

References (43)
  • 2
    • 84910681076 scopus 로고    scopus 로고
    • (accessed 12.8.14).
    • (accessed 12.8.14). http://newhope360.com/site-files/newhope360.com/files/uploads/2013/04/TOC_Global_final.pdf.
  • 3
    • 84910631674 scopus 로고    scopus 로고
    • (accessed 12.8.14).
    • (accessed 12.8.14). http://www.bizjournals.com/prnewswire/press_releases/2014/02/11/CL62435.
  • 4
    • 84910669967 scopus 로고    scopus 로고
    • (accessed 12.8.14).
    • (accessed 12.8.14). http://www.nextforecast.com/download/NEXT_Sample_2015.pdf.
  • 5
    • 84910617935 scopus 로고    scopus 로고
    • (accessed 12.8.14).
    • (accessed 12.8.14). http://www.nutraingredients.com/Industry/A-global-look-at-supplements-on-the-rise.
  • 6
    • 34548211822 scopus 로고    scopus 로고
    • The NIH analytical methods and reference materials program for dietary supplements
    • Betz J.M., Fisher K.D., Saldanha L.G., Coates P.M. The NIH analytical methods and reference materials program for dietary supplements. Anal. Bioanal. Chem. 2007, 389:19-25.
    • (2007) Anal. Bioanal. Chem. , vol.389 , pp. 19-25
    • Betz, J.M.1    Fisher, K.D.2    Saldanha, L.G.3    Coates, P.M.4
  • 7
    • 84910634279 scopus 로고    scopus 로고
    • http://www.lexology.com/library/detail.aspx%3Fg=a5bcdafc-8ae0-4da6-bc34-0d2ba5aa1694.
  • 8
    • 84910669999 scopus 로고    scopus 로고
    • (accessed 12.8.14).
    • (accessed 12.8.14). http://www.acsu.buffalo.edu/~shlevy/dietsuppqualitysafetyefficacy.htm.
  • 9
    • 84878521132 scopus 로고    scopus 로고
    • The frequency and characteristics of dietary supplement recalls in the United States
    • Harel Z., Harel S., Wald R., Mamdani M., Bell C.M. The frequency and characteristics of dietary supplement recalls in the United States. JAMA Int. Med. 2013, 173:926-928.
    • (2013) JAMA Int. Med. , vol.173 , pp. 926-928
    • Harel, Z.1    Harel, S.2    Wald, R.3    Mamdani, M.4    Bell, C.M.5
  • 10
    • 84865076838 scopus 로고    scopus 로고
    • Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks
    • Venhuis B.J., de Kaste D. Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks. J. Pharm. Biomed. Anal. 2012, 69:196-208.
    • (2012) J. Pharm. Biomed. Anal. , vol.69 , pp. 196-208
    • Venhuis, B.J.1    de Kaste, D.2
  • 11
    • 84889577311 scopus 로고    scopus 로고
    • Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges
    • Patel D.N., Li L., Kee C.L., Ge X., Low M.Y., Koh H.L. Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges. J. Pharm. Biomed. Anal. 2014, 87:176-190.
    • (2014) J. Pharm. Biomed. Anal. , vol.87 , pp. 176-190
    • Patel, D.N.1    Li, L.2    Kee, C.L.3    Ge, X.4    Low, M.Y.5    Koh, H.L.6
  • 12
    • 84882249811 scopus 로고    scopus 로고
    • Analytical methods for the detection of undeclared synthetic drugs in traditional herbal medicines as adulterants
    • Haneef J., Shaharyar M., Husain A., Rashid M., Mishra R., Siddique N.A., Pal M. Analytical methods for the detection of undeclared synthetic drugs in traditional herbal medicines as adulterants. Drug Test. Anal. 2013, 5:607-613.
    • (2013) Drug Test. Anal. , vol.5 , pp. 607-613
    • Haneef, J.1    Shaharyar, M.2    Husain, A.3    Rashid, M.4    Mishra, R.5    Siddique, N.A.6    Pal, M.7
  • 13
    • 84878807263 scopus 로고    scopus 로고
    • Simultaneous determination of 38 phosphodiestrase-5 inhibitors in illicit erectile dysfunction products by liquid chromatography-electrospray ionization-tandem mass spectrometry
    • Lee E.S., Lee J.H., Han K.M., Kim J.W., Hwang I.S., Cho S., Han S.Y., Kim J. Simultaneous determination of 38 phosphodiestrase-5 inhibitors in illicit erectile dysfunction products by liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2013, 83:171-178.
    • (2013) J. Pharm. Biomed. Anal. , vol.83 , pp. 171-178
    • Lee, E.S.1    Lee, J.H.2    Han, K.M.3    Kim, J.W.4    Hwang, I.S.5    Cho, S.6    Han, S.Y.7    Kim, J.8
  • 14
    • 84886384142 scopus 로고    scopus 로고
    • Monitoring by LC-MS/MS of 48 compounds of sildenafil, tadalafil, vardenafil and their analogues in illicit health food products in the Korean market advertised as enhancing male sexual performance
    • Lee J.H., Kim N.S., Han K.M., Kim S.H., Cho S., Kim W.S. Monitoring by LC-MS/MS of 48 compounds of sildenafil, tadalafil, vardenafil and their analogues in illicit health food products in the Korean market advertised as enhancing male sexual performance. Food Addit. Contam. A Chem Anal. Control Expo. Risk Assess. 2013, 30:1849-1857.
    • (2013) Food Addit. Contam. A Chem Anal. Control Expo. Risk Assess. , vol.30 , pp. 1849-1857
    • Lee, J.H.1    Kim, N.S.2    Han, K.M.3    Kim, S.H.4    Cho, S.5    Kim, W.S.6
  • 15
    • 84880341377 scopus 로고    scopus 로고
    • Application of high-performance liquid chromatography with charged aerosol detection for universal quantitation of undeclared phosphodiesterase-5 inhibitors in herbal dietary supplements
    • Poplawska M., Blazewicz A., Bukowinska K., Fijalek Z. Application of high-performance liquid chromatography with charged aerosol detection for universal quantitation of undeclared phosphodiesterase-5 inhibitors in herbal dietary supplements. J. Pharm. Biomed. Anal. 2013, 84:232-243.
    • (2013) J. Pharm. Biomed. Anal. , vol.84 , pp. 232-243
    • Poplawska, M.1    Blazewicz, A.2    Bukowinska, K.3    Fijalek, Z.4
  • 16
    • 79951720474 scopus 로고    scopus 로고
    • Rapid screening test for adulteration in raw materials of dietary supplements
    • Champagne A.B., Emmel K.V. Rapid screening test for adulteration in raw materials of dietary supplements. Vib. Spectrosc. 2011, 55:216-223.
    • (2011) Vib. Spectrosc. , vol.55 , pp. 216-223
    • Champagne, A.B.1    Emmel, K.V.2
  • 17
    • 0142030118 scopus 로고    scopus 로고
    • Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction
    • Shin M.H., Hong M.K., Kim W.S., Lee Y.J., Jeoung Y.C. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food Addit. Contam. 2003, 20:793-796.
    • (2003) Food Addit. Contam. , vol.20 , pp. 793-796
    • Shin, M.H.1    Hong, M.K.2    Kim, W.S.3    Lee, Y.J.4    Jeoung, Y.C.5
  • 18
    • 84896532521 scopus 로고    scopus 로고
    • Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement
    • Zhang G., Yu Y., Wu X., Li J. Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement. J. Pharm. Biomed. Anal. 2014, 94:210-214.
    • (2014) J. Pharm. Biomed. Anal. , vol.94 , pp. 210-214
    • Zhang, G.1    Yu, Y.2    Wu, X.3    Li, J.4
  • 19
    • 84898013449 scopus 로고    scopus 로고
    • Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement
    • Schramek N., Wollein U., Eisenreich W. Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement. J. Pharm. Biomed. Anal. 2014, 96:45-53.
    • (2014) J. Pharm. Biomed. Anal. , vol.96 , pp. 45-53
    • Schramek, N.1    Wollein, U.2    Eisenreich, W.3
  • 20
    • 84902081514 scopus 로고    scopus 로고
    • Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry
    • References quoted in
    • Kee C.L., Koh H.L., Bloodworth B.C., Zeng Y., Kiang K.H., Low M.Y., Ge X. Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry. J. Pharm. Biomed. Anal. 2014, 98:153-159. and references quoted in.
    • (2014) J. Pharm. Biomed. Anal. , vol.98 , pp. 153-159
    • Kee, C.L.1    Koh, H.L.2    Bloodworth, B.C.3    Zeng, Y.4    Kiang, K.H.5    Low, M.Y.6    Ge, X.7
  • 25
    • 84858071347 scopus 로고    scopus 로고
    • Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants
    • Balayssac S., Gilard V., Zedde C., Martino R., Malet-Martino M. Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants. J. Pharm. Biomed. Anal. 2012, 63:135-150.
    • (2012) J. Pharm. Biomed. Anal. , vol.63 , pp. 135-150
    • Balayssac, S.1    Gilard, V.2    Zedde, C.3    Martino, R.4    Malet-Martino, M.5
  • 26
    • 84898771521 scopus 로고    scopus 로고
    • Chromatographic separation and identification of sildenafil and yohimbine analogues illegally added in herbal supplements
    • InTech, Rijeka, Croatia
    • Göker H., Coskun M., Ayhan-Kilcigil G. Chromatographic separation and identification of sildenafil and yohimbine analogues illegally added in herbal supplements. Chromatography and Its Applications 2012, vol. 3:51-68. InTech, Rijeka, Croatia. http://www.intechopen.com/books/chromatography-and-its-applications/.
    • (2012) Chromatography and Its Applications , vol.3 , pp. 51-68
    • Göker, H.1    Coskun, M.2    Ayhan-Kilcigil, G.3
  • 27
    • 84871897475 scopus 로고    scopus 로고
    • Detection and structure elucidation of hydroxythiovardenafil as an adulterant in a herbal dietary supplement
    • Jankovics P., Lohner S., Darcsi A., Nemeth-Palotas J., Beni S. Detection and structure elucidation of hydroxythiovardenafil as an adulterant in a herbal dietary supplement. J. Pharm. Biomed. Anal. 2013, 74:83-91.
    • (2013) J. Pharm. Biomed. Anal. , vol.74 , pp. 83-91
    • Jankovics, P.1    Lohner, S.2    Darcsi, A.3    Nemeth-Palotas, J.4    Beni, S.5
  • 29
    • 84866243856 scopus 로고    scopus 로고
    • Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements
    • Kee C.L., Ge X., Koh H.L., Low M.Y. Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements. J. Pharm. Biomed. Anal. 2012, 70:265-272.
    • (2012) J. Pharm. Biomed. Anal. , vol.70 , pp. 265-272
    • Kee, C.L.1    Ge, X.2    Koh, H.L.3    Low, M.Y.4
  • 30
    • 79961128640 scopus 로고    scopus 로고
    • Identification of a new sildenafil analogue in a health supplement
    • Ge X., Li L., Koh H.L., Low M.Y. Identification of a new sildenafil analogue in a health supplement. J. Pharm. Biomed. Anal. 2011, 56:491-496.
    • (2011) J. Pharm. Biomed. Anal. , vol.56 , pp. 491-496
    • Ge, X.1    Li, L.2    Koh, H.L.3    Low, M.Y.4
  • 31
    • 20644457703 scopus 로고    scopus 로고
    • Low-energy collision-induced dissociation of sildenafil thiono analogues: gas-phase intramolecular nucleophilic substitution through ion-neutral complexes between a cationic substrate and a thione-containing neutral nucleophile
    • Lee J., Yoo H.H., Kang M.Y., Kim D.H. Low-energy collision-induced dissociation of sildenafil thiono analogues: gas-phase intramolecular nucleophilic substitution through ion-neutral complexes between a cationic substrate and a thione-containing neutral nucleophile. Rapid Commun. Mass Spectrom. 2005, 19:1767-1770.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1767-1770
    • Lee, J.1    Yoo, H.H.2    Kang, M.Y.3    Kim, D.H.4
  • 32
    • 33746882104 scopus 로고    scopus 로고
    • Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices
    • Gratz S.R., Gamble B.M., Flurer R.A. Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices. Rapid Commun. Mass Spectrom. 2006, 20:2317-2327.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 2317-2327
    • Gratz, S.R.1    Gamble, B.M.2    Flurer, R.A.3
  • 33
    • 84910634948 scopus 로고
    • Pyrazolopyrimidinone antianginal agents
    • A.S. Bell, K.N. Terrett, Pyrazolopyrimidinone antianginal agents, European Patent 0526004 (1993), p. A1.
    • (1993) European , pp. A1
    • Bell, A.S.1    Terrett, K.N.2
  • 37
    • 84894088921 scopus 로고    scopus 로고
    • Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector
    • Poplawska M., Blazewicz A., Zolek P., Fijalek Z. Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector. J. Pharm. Biomed. Anal. 2014, 94:45-53.
    • (2014) J. Pharm. Biomed. Anal. , vol.94 , pp. 45-53
    • Poplawska, M.1    Blazewicz, A.2    Zolek, P.3    Fijalek, Z.4
  • 38
    • 0034041437 scopus 로고    scopus 로고
    • Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro
    • Chen J., Chiou W.F., Chen C.C., Chen C.F. Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. J. Urol. 2000, 163:1975-1980.
    • (2000) J. Urol. , vol.163 , pp. 1975-1980
    • Chen, J.1    Chiou, W.F.2    Chen, C.C.3    Chen, C.F.4
  • 41
    • 84862141500 scopus 로고    scopus 로고
    • A multidisciplinary approach for the analysis of an adulterated dietary supplement where the active pharmaceutical ingredient was embedded in the capsule shell
    • Lanzarotta A., Crowe J.B., Witkowski M., Gamble B.M. A multidisciplinary approach for the analysis of an adulterated dietary supplement where the active pharmaceutical ingredient was embedded in the capsule shell. J. Pharm. Biomed. Anal. 2012, 67-68:22-27.
    • (2012) J. Pharm. Biomed. Anal. , pp. 22-27
    • Lanzarotta, A.1    Crowe, J.B.2    Witkowski, M.3    Gamble, B.M.4
  • 42
    • 84879836688 scopus 로고    scopus 로고
    • Adulteration of purported herbal and natural sexual performance enhancement dietary supplements with synthetic phosphodiesterase type 5 inhibitors
    • Campbell N., Clark J.P., Stecher V.J., Thomas J.W., Callanan A.C., Donnelly B.F., Goldstein I., Kaminetsky J.C. Adulteration of purported herbal and natural sexual performance enhancement dietary supplements with synthetic phosphodiesterase type 5 inhibitors. J. Sex. Med. 2013, 10:1842-1849.
    • (2013) J. Sex. Med. , vol.10 , pp. 1842-1849
    • Campbell, N.1    Clark, J.P.2    Stecher, V.J.3    Thomas, J.W.4    Callanan, A.C.5    Donnelly, B.F.6    Goldstein, I.7    Kaminetsky, J.C.8
  • 43
    • 70449699709 scopus 로고    scopus 로고
    • Safety and quality assessment of 175 illegal sexual enhancement products seized in red-light districts in Singapore
    • Low M.Y., Zeng Y., Li L., Ge X.W., Lee R., Bloodworth B.C., Koh H.L. Safety and quality assessment of 175 illegal sexual enhancement products seized in red-light districts in Singapore. Drug Saf. 2009, 32:1141-1146.
    • (2009) Drug Saf. , vol.32 , pp. 1141-1146
    • Low, M.Y.1    Zeng, Y.2    Li, L.3    Ge, X.W.4    Lee, R.5    Bloodworth, B.C.6    Koh, H.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.