-
1
-
-
77958524704
-
Pathway-based therapies for age-related macular degeneration: An integrated survey of emerging treatment alternatives
-
Zarbin MA, Rosenfeld PJ: Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternatives. Retina 2010;30:1350-1367.
-
(2010)
Retina
, vol.30
, pp. 1350-1367
-
-
Zarbin, M.A.1
Rosenfeld, P.J.2
-
2
-
-
0034800655
-
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8
-
Age-Related Eye Disease Study Research Group: A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8. Arch Ophthalmol 2001;119:1417-1436.
-
(2001)
Arch Ophthalmol
, vol.119
, pp. 1417-1436
-
-
-
3
-
-
0038692733
-
Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial
-
Omenn GS, Goodman GE, Thornquist MD, et al: Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Nat Cancer Inst 1996;88:1550-1559.
-
(1996)
J Nat Cancer Inst
, vol.88
, pp. 1550-1559
-
-
Omenn, G.S.1
Goodman, G.E.2
Thornquist, M.D.3
-
4
-
-
0010607277
-
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
-
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 1994;330:1029-1035.
-
(1994)
N Engl J Med
, vol.330
, pp. 1029-1035
-
-
-
5
-
-
29244486457
-
Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with agerelated macular degeneration
-
Moriarty-Craige SE, Adkison J, Lynn M, et al: Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with agerelated macular degeneration. Am J Ophthalmol 2005;140:1020-1026.
-
(2005)
Am J Ophthalmol
, vol.140
, pp. 1020-1026
-
-
Moriarty-Craige, S.E.1
Adkison, J.2
Lynn, M.3
-
6
-
-
84862806474
-
The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: A pilot investigation
-
Brantley MA Jr, Osborn MP, Sanders BJ, et al: The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Am J Ophthalmol 2012;153:1104-1109.e2.
-
(2012)
Am J Ophthalmol
, vol.153
, pp. 1104-1109e2
-
-
Brantley, M.A.1
Osborn, M.P.2
Sanders, B.J.3
-
7
-
-
84877734641
-
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
-
Age-Related Eye Disease Study 2 Research Group: Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 2013;309:2005-2015.
-
(2013)
JAMA
, vol.309
, pp. 2005-2015
-
-
-
8
-
-
84894229056
-
Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No 3
-
Age-Related Eye Disease Study 2 Research Group; Chew EY, Clemons TE, et al: Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No 3. JAMA Ophthalmol 2014;132:142-149.
-
(2014)
JAMA Ophthalmol
, vol.132
, pp. 142-149
-
-
Chew, E.Y.1
Clemons, T.E.2
-
9
-
-
0027812303
-
Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins
-
Packer L: Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins. Ann NY Acad Sci 1993;691:48-60.
-
(1993)
Ann NY Acad Sci
, vol.691
, pp. 48-60
-
-
Packer, L.1
-
10
-
-
84993905629
-
Carotenoids protect against cell membrane damage by the nitrogen dioxide radical
-
Bohm F, Tinkler JH, Truscott TG: Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nat Med 1995;1:98-99.
-
(1995)
Nat Med
, vol.1
, pp. 98-99
-
-
Bohm, F.1
Tinkler, J.H.2
Truscott, T.G.3
-
11
-
-
0029955177
-
Sex differences in macular pigment optical density: Relation to plasma carotenoid concentrations and dietary patterns
-
Hammond BR Jr, Curran-Celentano J, Judd S, et al: Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Vision Res 1996;36:2001-2012.
-
(1996)
Vision Res
, vol.36
, pp. 2001-2012
-
-
Hammond, B.R.1
Curran-Celentano, J.2
Judd, S.3
-
12
-
-
0030249886
-
Cigarette smoking and retinal carotenoids: Implications for age-related macular degeneration
-
Hammond BR Jr, Wooten BR, Snodderly DM: Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration. Vision Res 1996;36:3003-3009.
-
(1996)
Vision Res
, vol.36
, pp. 3003-3009
-
-
Hammond, B.R.1
Wooten, B.R.2
Snodderly, D.M.3
-
13
-
-
0030009304
-
Iris color and macular pigment optical density
-
Hammond BR Jr, Fuld K, Snodderly DM: Iris color and macular pigment optical density. Exp Eye Res 1996;62:293-297.
-
(1996)
Exp Eye Res
, vol.62
, pp. 293-297
-
-
Hammond, B.R.1
Fuld, K.2
Snodderly, D.M.3
-
14
-
-
12644299593
-
Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin
-
Hammond BR Jr, Wooten BR, Snodderly DM: Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom Vis Sci 1997;74:499-504.
-
(1997)
Optom Vis Sci
, vol.74
, pp. 499-504
-
-
Hammond, B.R.1
Wooten, B.R.2
Snodderly, D.M.3
-
16
-
-
77956747928
-
The macular pigment: A possible role in protection from age-related macular degeneration
-
Landrum JT, Bone RA, Kilburn MD: The macular pigment: a possible role in protection from age-related macular degeneration. Adv Pharmacol 1997;38:537-556.
-
(1997)
Adv Pharmacol
, vol.38
, pp. 537-556
-
-
Landrum, J.T.1
Bone, R.A.2
Kilburn, M.D.3
-
17
-
-
0035166491
-
Macular pigment in donor eyes with and without AMD: A case-control study
-
Bone RA, Landrum JT, Mayne ST, et al: Macular pigment in donor eyes with and without AMD: a case-control study. Invest Ophthalmol Vis Sci 2001;42:235-240.
-
(2001)
Invest Ophthalmol Vis Sci
, vol.42
, pp. 235-240
-
-
Bone, R.A.1
Landrum, J.T.2
Mayne, S.T.3
-
18
-
-
0035142770
-
Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population
-
Beatty S, Murray IJ, Henson DB, et al: Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci 2001;42:439-446.
-
(2001)
Invest Ophthalmol Vis Sci
, vol.42
, pp. 439-446
-
-
Beatty, S.1
Murray, I.J.2
Henson, D.B.3
-
19
-
-
0035069027
-
Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
-
Holz FG, Bellman C, Staudt S, et al: Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 2001;42:1051-1056.
-
(2001)
Invest Ophthalmol Vis Sci
, vol.42
, pp. 1051-1056
-
-
Holz, F.G.1
Bellman, C.2
Staudt, S.3
-
20
-
-
0029562829
-
Lipofuscin of the retinal pigment epithelium: A review
-
Kennedy CJ, Rakoczy PE, Constable IJ: Lipofuscin of the retinal pigment epithelium: a review. Eye 1995;9:763-771.
-
(1995)
Eye
, vol.9
, pp. 763-771
-
-
Kennedy, C.J.1
Rakoczy, P.E.2
Constable, I.J.3
-
21
-
-
2942617209
-
Dark adaptation and the retinoid cycle of vision
-
Lamb TD, Pugh EN Jr: Dark adaptation and the retinoid cycle of vision. Prog Retin Eye Res 2004;23:307-380.
-
(2004)
Prog Retin Eye Res
, vol.23
, pp. 307-380
-
-
Lamb, T.D.1
Pugh, E.N.2
-
22
-
-
0033538438
-
Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
-
Weng J, Mata NL, Azarian SM, et al: Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 1999;98:13-23.
-
(1999)
Cell
, vol.98
, pp. 13-23
-
-
Weng, J.1
Mata, N.L.2
Azarian, S.M.3
-
23
-
-
11144240503
-
N-retinylidenephosphatidylethanolamine is the preferred retinoid substrate for the photoreceptorspecific ABC transporter ABCA4 (ABCR)
-
Beharry S, Zhong M, Molday RS: N-retinylidenephosphatidylethanolamine is the preferred retinoid substrate for the photoreceptorspecific ABC transporter ABCA4 (ABCR). J Biol Chem 2004;279:53972-53979.
-
(2004)
J Biol Chem
, vol.279
, pp. 53972-53979
-
-
Beharry, S.1
Zhong, M.2
Molday, R.S.3
-
24
-
-
0034646715
-
Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol
-
Rattner A, Smallwood PM, Nathans J: Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem 2000;275:11034-11043.
-
(2000)
J Biol Chem
, vol.275
, pp. 11034-11043
-
-
Rattner, A.1
Smallwood, P.M.2
Nathans, J.3
-
25
-
-
33846027877
-
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice
-
Maeda A, Maeda T, Imanishi Y, et al: Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem 2006;281:37697-37704.
-
(2006)
J Biol Chem
, vol.281
, pp. 37697-37704
-
-
Maeda, A.1
Maeda, T.2
Imanishi, Y.3
-
26
-
-
0842266594
-
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye
-
Imanishi Y, Batten ML, Piston DW, et al: Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol 2004;164:373-383.
-
(2004)
J Cell Biol
, vol.164
, pp. 373-383
-
-
Imanishi, Y.1
Batten, M.L.2
Piston, D.W.3
-
27
-
-
4143126732
-
Retinosomes: New insights into intracellular managing of hydrophobic substances in lipid bodies
-
Imanishi Y, Gerke V, Palczewski K: Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol 2004;166:447-453.
-
(2004)
J Cell Biol
, vol.166
, pp. 447-453
-
-
Imanishi, Y.1
Gerke, V.2
Palczewski, K.3
-
28
-
-
26444596185
-
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle
-
Redmond TM, Poliakov E, Yu S, et al: Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc Natl Acad Sci USA 2005;102:13658-13663.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13658-13663
-
-
Redmond, T.M.1
Poliakov, E.2
Yu, S.3
-
29
-
-
23744447355
-
RPE65 is the retinoid isomerase in bovine retinal pigment epithelium
-
Jin M, Li S, Moghrabi WN, et al: RPE65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell 2005;122:449-459.
-
(2005)
Cell
, vol.122
, pp. 449-459
-
-
Jin, M.1
Li, S.2
Moghrabi, W.N.3
-
30
-
-
24644507141
-
RPE65 is the isomerohydrolase in the retinoid visual cycle
-
Moiseyev G, Chen Y, Takahashi Y, et al: RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci USA 2005;102:12413-12418.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12413-12418
-
-
Moiseyev, G.1
Chen, Y.2
Takahashi, Y.3
-
31
-
-
0035980109
-
Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus
-
Jang GF, Van Hooser JP, Kuksa V, et al: Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem 2001;276:32456-465.
-
(2001)
J Biol Chem
, vol.276
, pp. 32456-32465
-
-
Jang, G.F.1
Van Hooser, J.P.2
Kuksa, V.3
-
32
-
-
77958600374
-
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins
-
Farjo KM, Moiseyev G, Takahashi Y, et al: The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci 2009;50:5089-5097.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 5089-5097
-
-
Farjo, K.M.1
Moiseyev, G.2
Takahashi, Y.3
-
33
-
-
0242662700
-
A2E, a byproduct of the visual cycle
-
Sparrow JR, Fishkin N, Zhou J, et al: A2E, a byproduct of the visual cycle. Vision Res 2003;43:2983-2990.
-
(2003)
Vision Res
, vol.43
, pp. 2983-2990
-
-
Sparrow, J.R.1
Fishkin, N.2
Zhou, J.3
-
34
-
-
33644795859
-
Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: A potential therapy for treatment of lipofuscin-based retinal diseases
-
Radu RA, Han Y, Bui TV, et al: Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci 2005;46:4393-4401.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 4393-4401
-
-
Radu, R.A.1
Han, Y.2
Bui, T.V.3
-
35
-
-
0242438630
-
Retinoid cycle in the vertebrate retina: Experimental approaches and mechanisms of isomerization
-
Kuksa V, Imanishi Y, Batten M, et al: Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res 2003;43:2959-2981.
-
(2003)
Vision Res
, vol.43
, pp. 2959-2981
-
-
Kuksa, V.1
Imanishi, Y.2
Batten, M.3
-
36
-
-
0033198844
-
Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
-
Quadro L, Blaner WS, Salchow DJ, et al: Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J 1999;18:4633-4644.
-
(1999)
EMBO J
, vol.18
, pp. 4633-4644
-
-
Quadro, L.1
Blaner, W.S.2
Salchow, D.J.3
-
37
-
-
0037168472
-
Retinol-binding protein-deficient mice: Biochemical basis for impaired vision
-
Vogel S, Piantedosi R, O'Byrne SM, et al: Retinol-binding protein-deficient mice: biochemical basis for impaired vision. Biochemistry 2002;41:15360-15368.
-
(2002)
Biochemistry
, vol.41
, pp. 15360-15368
-
-
Vogel, S.1
Piantedosi, R.2
O'Byrne, S.M.3
-
38
-
-
84874950305
-
Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration
-
Mata NL, Lichter JB, Vogel R, et al: Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration. Retina 2013;33:498-507.
-
(2013)
Retina
, vol.33
, pp. 498-507
-
-
Mata, N.L.1
Lichter, J.B.2
Vogel, R.3
-
39
-
-
0035852747
-
Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy
-
Sieving PA, Chaudhry P, Kondo M, et al: Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Proc Natl Acad Sci USA 2001;98:1835-1840.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1835-1840
-
-
Sieving, P.A.1
Chaudhry, P.2
Kondo, M.3
-
40
-
-
0037447253
-
Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
-
Radu RA, Mata NL, Nusinowitz S, et al: Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci USA 2003;100:4742-4747.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4742-4747
-
-
Radu, R.A.1
Mata, N.L.2
Nusinowitz, S.3
-
41
-
-
33748937039
-
Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice
-
Maeda A, Maeda T, Golczak M, et al: Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol 2006;70:1220-1229.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1220-1229
-
-
Maeda, A.1
Maeda, T.2
Golczak, M.3
-
42
-
-
77954958266
-
Visual cycle modulation in neurovascular retinopathy
-
Akula JD, Hansen RM, Tzekov R, et al: Visual cycle modulation in neurovascular retinopathy. Exp Eye Res 2010;91:153-161.
-
(2010)
Exp Eye Res
, vol.91
, pp. 153-161
-
-
Akula, J.D.1
Hansen, R.M.2
Tzekov, R.3
-
43
-
-
84855205404
-
Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator
-
Kubota R, Boman NL, David R, et al: Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator. Retina 2012;32:183-188.
-
(2012)
Retina
, vol.32
, pp. 183-188
-
-
Kubota, R.1
Boman, N.L.2
David, R.3
-
44
-
-
0036741098
-
A role for local inflammation in the formation of drusen in the aging eye
-
Anderson DH, Mullins RF, Hageman GS, et al: A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002;134:411-431.
-
(2002)
Am J Ophthalmol
, vol.134
, pp. 411-431
-
-
Anderson, D.H.1
Mullins, R.F.2
Hageman, G.S.3
-
45
-
-
77749307396
-
Complement, age-related macular degeneration and a vision of the future
-
Gehrs KM, Jackson JR, Brown EN, et al: Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol 2010;128:349-358.
-
(2010)
Arch Ophthalmol
, vol.128
, pp. 349-358
-
-
Gehrs, K.M.1
Jackson, J.R.2
Brown, E.N.3
-
46
-
-
77954278649
-
Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration
-
Cherepanoff S, McMenamin P, Gillies MC, et al: Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol 2010;94:918-925.
-
(2010)
Br J Ophthalmol
, vol.94
, pp. 918-925
-
-
Cherepanoff, S.1
McMenamin, P.2
Gillies, M.C.3
-
47
-
-
0035699547
-
Complement activation and inflammatory processes in Drusen formation and age related macular degeneration
-
Johnson LV, Leitner WP, Staples MK, et al: Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp Eye Res 2001;73:887-896.
-
(2001)
Exp Eye Res
, vol.73
, pp. 887-896
-
-
Johnson, L.V.1
Leitner, W.P.2
Staples, M.K.3
-
48
-
-
21044453724
-
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
-
Hageman GS, Anderson DH, Johnson LV, et al: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 2005;102:7227-7232.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7227-7232
-
-
Hageman, G.S.1
Anderson, D.H.2
Johnson, L.V.3
-
49
-
-
20244380171
-
Complement factor H polymorphism in age-related macular degeneration
-
Klein RJ, Zeiss C, Chew EY, et al: Complement factor H polymorphism in age-related macular degeneration. Science 2005;308:385-389.
-
(2005)
Science
, vol.308
, pp. 385-389
-
-
Klein, R.J.1
Zeiss, C.2
Chew, E.Y.3
-
50
-
-
17244379811
-
Complement factor H polymorphism and age-related macular degeneration
-
Edwards AO, Ritter R 3rd, Abel KJ, et al: Complement factor H polymorphism and age-related macular degeneration. Science 2005;308:421-424.
-
(2005)
Science
, vol.308
, pp. 421-424
-
-
Edwards, A.O.1
Ritter, R.2
Abel, K.J.3
-
51
-
-
20244388812
-
Complement factor H variant increases the risk of age-related macular degeneration
-
Haines JL, Hauser MA, Schmidt S, et al: Complement factor H variant increases the risk of age-related macular degeneration. Science 2005;308:419-421.
-
(2005)
Science
, vol.308
, pp. 419-421
-
-
Haines, J.L.1
Hauser, M.A.2
Schmidt, S.3
-
52
-
-
33749123246
-
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
-
Hughes AE, Orr N, Esfandiary H, et al: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet 2006;38:1173-1177.
-
(2006)
Nat Genet
, vol.38
, pp. 1173-1177
-
-
Hughes, A.E.1
Orr, N.2
Esfandiary, H.3
-
53
-
-
34247573496
-
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration
-
Skerka C, Lauer N, Weinberger AA, et al: Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. Mol Immunol 2007;44:3398-3406.
-
(2007)
Mol Immunol
, vol.44
, pp. 3398-3406
-
-
Skerka, C.1
Lauer, N.2
Weinberger, A.A.3
-
54
-
-
32044474231
-
CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD
-
Magnusson KP, Duan S, Sigurdsson H, et al: CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med 2006;3:e5.
-
(2006)
PLoS Med
, vol.3
, pp. e5
-
-
Magnusson, K.P.1
Duan, S.2
Sigurdsson, H.3
-
55
-
-
33748325757
-
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration
-
Li M, Atmaca-Sonmez P, Othman M, et al: CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet 2006;38:1049-1054.
-
(2006)
Nat Genet
, vol.38
, pp. 1049-1054
-
-
Li, M.1
Atmaca-Sonmez, P.2
Othman, M.3
-
56
-
-
33645419787
-
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
-
Gold B, Merriam JE, Zernant J, et al: Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet 2006;38:458-462.
-
(2006)
Nat Genet
, vol.38
, pp. 458-462
-
-
Gold, B.1
Merriam, J.E.2
Zernant, J.3
-
57
-
-
34548406001
-
Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
-
Spencer KL, Hauser MA, Olson LM, et al: Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. Hum Mol Genet 2007;16:1986-1992.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1986-1992
-
-
Spencer, K.L.1
Hauser, M.A.2
Olson, L.M.3
-
58
-
-
34547764305
-
Complement C3 variant and the risk of age-related macular degeneration
-
Yates JR, Sepp T, Matharu BK, et al: Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 2007;357:553-561.
-
(2007)
N Engl J Med
, vol.357
, pp. 553-561
-
-
Yates, J.R.1
Sepp, T.2
Matharu, B.K.3
-
59
-
-
56249123595
-
Association between the SERPING1 gene and agerelated macular degeneration: A two-stage case-control study
-
Ennis S, Jomary C, Mullins R, et al: Association between the SERPING1 gene and agerelated macular degeneration: a two-stage case-control study. Lancet 2008;372:1828-1834.
-
(2008)
Lancet
, vol.372
, pp. 1828-1834
-
-
Ennis, S.1
Jomary, C.2
Mullins, R.3
-
60
-
-
34748819371
-
Variation in complement factor 3 is associated with risk of age-related macular degeneration
-
Maller JB, Fagerness JA, Reynolds RC, et al: Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet 2007;39:1200-1201.
-
(2007)
Nat Genet
, vol.39
, pp. 1200-1201
-
-
Maller, J.B.1
Fagerness, J.A.2
Reynolds, R.C.3
-
61
-
-
57649215855
-
Variation near complement factor I is associated with risk of advanced AMD
-
Fagerness JA, Maller JB, Neale BM, et al: Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Ge net 2009;17:100-104.
-
(2009)
Eur J Hum Ge Net
, vol.17
, pp. 100-104
-
-
Fagerness, J.A.1
Maller, J.B.2
Neale, B.M.3
-
62
-
-
31144460785
-
The central role of the alternative complement pathway in human disease
-
Thurman JM, Holers VM: The central role of the alternative complement pathway in human disease. J Immunol 2006;176:1305-1310.
-
(2006)
J Immunol
, vol.176
, pp. 1305-1310
-
-
Thurman, J.M.1
Holers, V.M.2
-
63
-
-
0033775686
-
Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins
-
Sohn JH, Kaplan HJ, Suk HJ, et al: Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci 2000;41:3492-3502.
-
(2000)
Invest Ophthalmol Vis Sci
, vol.41
, pp. 3492-3502
-
-
Sohn, J.H.1
Kaplan, H.J.2
Suk, H.J.3
-
64
-
-
67650547973
-
Oxidative stress renders retinal pigment epithelial cells susceptible to complementmediated injury
-
Thurman JM, Renner B, Kunchithapautham K, et al: Oxidative stress renders retinal pigment epithelial cells susceptible to complementmediated injury. J Biol Chem 2009;284:16939-16947.
-
(2009)
J Biol Chem
, vol.284
, pp. 16939-16947
-
-
Thurman, J.M.1
Renner, B.2
Kunchithapautham, K.3
-
65
-
-
34547963062
-
Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3
-
Wu Z, Lauer TW, Sick A, et al: Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. J Biol Chem 2007;282:22414-22425.
-
(2007)
J Biol Chem
, vol.282
, pp. 22414-22425
-
-
Wu, Z.1
Lauer, T.W.2
Sick, A.3
-
66
-
-
33750814597
-
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
-
Zhou J, Jang YP, Kim SR, et al: Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci USA 2006;103:16182-16187.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16182-16187
-
-
Zhou, J.1
Jang, Y.P.2
Kim, S.R.3
-
67
-
-
23244444708
-
Fas ligand but not complement is critical for control of experimental Staphylococcus aureus endophthalmitis
-
Engelbert M, Gilmore MS: Fas ligand but not complement is critical for control of experimental Staphylococcus aureus endophthalmitis. Invest Ophthalmol Vis Sci 2005;46:2479-2486.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 2479-2486
-
-
Engelbert, M.1
Gilmore, M.S.2
-
68
-
-
0028331986
-
Complement system and host defense against staphylococcal endophthalmitis
-
Giese MJ, Mondino BJ, Glasgow BJ, et al: Complement system and host defense against staphylococcal endophthalmitis. Invest Ophthalmol Vis Sci 1994;35:1026-1032.
-
(1994)
Invest Ophthalmol Vis Sci
, vol.35
, pp. 1026-1032
-
-
Giese, M.J.1
Mondino, B.J.2
Glasgow, B.J.3
-
69
-
-
0021982150
-
The complement system and host defense against Pseudomonas endophthalmitis
-
Aizuss DH, Mondino BJ, Sumner HL, et al: The complement system and host defense against Pseudomonas endophthalmitis. Invest Ophthalmol Vis Sci 1985;26:1262-1266.
-
(1985)
Invest Ophthalmol Vis Sci
, vol.26
, pp. 1262-1266
-
-
Aizuss, D.H.1
Mondino, B.J.2
Sumner, H.L.3
-
70
-
-
84896695485
-
Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: The COMPLETE study
-
Yehoshua Z, Alexandre De Amorim Garcia Filho C, Nunes RP, et al: Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study. Ophthalmology 2014;121:693-701.
-
(2014)
Ophthalmology
, vol.121
, pp. 693-701
-
-
Yehoshua, Z.1
Alexandre De Amorim Garcia Filho, C.2
Nunes, R.P.3
-
71
-
-
84887080613
-
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration
-
Seddon JM, Yu Y, Miller EC, et al: Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet 2013;45:1366-1370.
-
(2013)
Nat Genet
, vol.45
, pp. 1366-1370
-
-
Seddon, J.M.1
Yu, Y.2
Miller, E.C.3
-
72
-
-
84923809928
-
Lampalizumab (anti-factor D) in patients with geography atrophy: The MAHALO phase II results
-
New Orleans, November
-
Regillo CD: Lampalizumab (anti-factor D) in patients with geography atrophy: the MAHALO phase II results. Presented at the 2013 Ann Meet Am Acad Ophthalmol, New Orleans, November 2013.
-
(2013)
The 2013 Ann Meet Am Acad Ophthalmol
-
-
Regillo, C.D.1
-
73
-
-
84876831911
-
Treatment of geographic atrophy with subconjunctival sirolimus: Results of a phase I/II clinical trial
-
Wong WT, Dresner S, Forooghian F, et al: Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial. Invest Ophthalmol Vis Sci 2013;54:2941-2950.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.54
, pp. 2941-2950
-
-
Wong, W.T.1
Dresner, S.2
Forooghian, F.3
-
74
-
-
57649119813
-
Weekly vaccination with Copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration
-
Landa G, Butovsky O, Shoshani J, et al: Weekly vaccination with Copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration. Curr Eye Res 2008;33:1011-1013.
-
(2008)
Curr Eye Res
, vol.33
, pp. 1011-1013
-
-
Landa, G.1
Butovsky, O.2
Shoshani, J.3
-
75
-
-
0037015020
-
The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
-
Johnson LV, Leitner WP, Rivest AJ, et al: The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA 2002;99:11830-11835.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11830-11835
-
-
Johnson, L.V.1
Leitner, W.P.2
Rivest, A.J.3
-
77
-
-
65549156409
-
Amyloid-β up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration
-
Wang J, Ohno-Matsui K, Yoshida T, et al: Amyloid-β up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: another mechanism of complement activation in age-related macular degeneration. J Cell Physiol 2009;220:119-128.
-
(2009)
J Cell Physiol
, vol.220
, pp. 119-128
-
-
Wang, J.1
Ohno-Matsui, K.2
Yoshida, T.3
-
78
-
-
79961005068
-
Antiamyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
-
Ding JD, Johnson LV, Herrmann R, et al: Antiamyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci USA 2011;108:E279-E287.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. E279-E287
-
-
Ding, J.D.1
Johnson, L.V.2
Herrmann, R.3
-
79
-
-
84879066188
-
Systemic administration of A-beta mAb reduces retinal deposition of A-beta and activated complement C3 in age-related macular degeneration mouse model
-
Catchpole I, Germaschewski V, Hoh Kam J, et al: Systemic administration of A-beta mAb reduces retinal deposition of A-beta and activated complement C3 in age-related macular degeneration mouse model. PLoS One 2013;8:e65518.
-
(2013)
PLoS One
, vol.8
, pp. e65518
-
-
Catchpole, I.1
Germaschewski, V.2
Hoh Kam, J.3
-
81
-
-
16244363706
-
Reduced foveolar choroidal blood flow in eyes with increasing AMD severity
-
Grunwald JE, Metelitsina TI, Dupont JC, et al: Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 2005;46:1033-1008.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 1033-1008
-
-
Grunwald, J.E.1
Metelitsina, T.I.2
Dupont, J.C.3
-
82
-
-
77955879911
-
Choroidal blood flow and progression of agerelated macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization
-
Boltz A, Luksch A, Wimpissinger B, et al: Choroidal blood flow and progression of agerelated macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization. Invest Ophthalmol Vis Sci 2010;51:4220-4225.
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 4220-4225
-
-
Boltz, A.1
Luksch, A.2
Wimpissinger, B.3
-
83
-
-
79957589195
-
A pilot, open-label study of the safety of MC-1101 in both normal volunteers and patients with early nonexudative age-related macular degeneration
-
Ralston PG, Sloan D, Waters-Honcu D, Saigal S, Torkildsen G: A pilot, open-label study of the safety of MC-1101 in both normal volunteers and patients with early nonexudative age-related macular degeneration. Invest Ophthalmol Vis Sci 2010;51: E-Abstract 913.
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 913
-
-
Ralston, P.G.1
Sloan, D.2
Waters-Honcu, D.3
Saigal, S.4
Torkildsen, G.5
-
84
-
-
0036875316
-
The role of apoptosis in age-related macular degeneration
-
Dunaief JL, Dentchev T, Ying GS, et al: The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002;120:1435-1442.
-
(2002)
Arch Ophthalmol
, vol.120
, pp. 1435-1442
-
-
Dunaief, J.L.1
Dentchev, T.2
Ying, G.S.3
-
85
-
-
77949751399
-
CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration
-
Li Y, Tao W, Luo L, et al: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 2010;5:e9495.
-
(2010)
PLoS One
, vol.5
, pp. e9495
-
-
Li, Y.1
Tao, W.2
Luo, L.3
-
86
-
-
0036784819
-
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
-
Tao W, Wen R, Goddard MB, et al: Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002;43:3292-3298.
-
(2002)
Invest Ophthalmol Vis Sci
, vol.43
, pp. 3292-3298
-
-
Tao, W.1
Wen, R.2
Goddard, M.B.3
-
87
-
-
79955032437
-
Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
-
Zhang K, Hopkins JJ, Heier JS, et al: Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci USA 2011;108:6241-6245.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 6241-6245
-
-
Zhang, K.1
Hopkins, J.J.2
Heier, J.S.3
-
88
-
-
0036349623
-
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
-
Bok D, Yasumura D, Matthes MT, et al: Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 2002;74:719-735.
-
(2002)
Exp Eye Res
, vol.74
, pp. 719-735
-
-
Bok, D.1
Yasumura, D.2
Matthes, M.T.3
-
89
-
-
31344453017
-
CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
-
Zeiss CJ, Allore HG, Towle V, et al: CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. Exp Eye Res 2006;82:395-404.
-
(2006)
Exp Eye Res
, vol.82
, pp. 395-404
-
-
Zeiss, C.J.1
Allore, H.G.2
Towle, V.3
-
90
-
-
0036489583
-
Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat
-
Lai RK, Chun T, Hasson D, et al: Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Vis Neurosci 2002;19:175-185.
-
(2002)
Vis Neurosci
, vol.19
, pp. 175-185
-
-
Lai, R.K.1
Chun, T.2
Hasson, D.3
-
91
-
-
0034754201
-
Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension
-
Wolde Mussie E, Ruiz G, Wijono M, et al: Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. Invest Ophthalmol Vis Sci 2001;42:2849-2855.
-
(2001)
Invest Ophthalmol Vis Sci
, vol.42
, pp. 2849-2855
-
-
Wolde Mussie, E.1
Ruiz, G.2
Wijono, M.3
-
92
-
-
0842268223
-
Role of alpha-2 agonists in neuroprotection
-
Wheeler L, Wolde Mussie E, Lai R: Role of alpha-2 agonists in neuroprotection. Surv Ophthalmol 2003;48(suppl 1):S47-S51.
-
(2003)
Surv Ophthalmol
, vol.48
, pp. S47-S51
-
-
Wheeler, L.1
Wolde Mussie, E.2
Lai, R.3
-
93
-
-
1242289391
-
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: Anti-apoptosis by alpha-2-adrenergic receptor activation
-
Tatton W, Chen D, Chalmers-Redman R, et al: Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Surv Ophthalmol 2003;48(suppl 1):S25-S37.
-
(2003)
Surv Ophthalmol
, vol.48
, pp. S25-S37
-
-
Tatton, W.1
Chen, D.2
Chalmers-Redman, R.3
-
94
-
-
85039695832
-
The promise of stem cells for agerelated macular degeneration and other retinal degenerative diseases
-
Zarbin M: The promise of stem cells for agerelated macular degeneration and other retinal degenerative diseases. Drug Discov Today Ther Strateg 2012.
-
(2012)
Drug Discov Today Ther Strateg
-
-
Zarbin, M.1
-
95
-
-
84874397454
-
Stem cells: A new paradigm for disease modeling and developing therapies for age-related macular degeneration
-
Melville H, Carpiniello M, Hollis K, et al: Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration. J Transl Med 2013;11:53.
-
(2013)
J Transl Med
, vol.11
, pp. 53
-
-
Melville, H.1
Carpiniello, M.2
Hollis, K.3
-
96
-
-
0024151007
-
Evolution of geographic atrophy of the retinal pigment epithelium
-
Sarks JP, Sarks SH, Killingsworth MC: Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond) 1988;2:552-577.
-
(1988)
Eye (Lond)
, vol.2
, pp. 552-577
-
-
Sarks, J.P.1
Sarks, S.H.2
Killingsworth, M.C.3
-
97
-
-
66149142749
-
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration
-
Zhu D, Wu J, Spee C, et al: BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem 2009;284:9529-9539.
-
(2009)
J Biol Chem
, vol.284
, pp. 9529-9539
-
-
Zhu, D.1
Wu, J.2
Spee, C.3
-
98
-
-
34748925885
-
Oxidative damage in age-related macular degeneration
-
Shen JK, Dong A, Hackett SF, et al: Oxidative damage in age-related macular degeneration. Histol Histopathol 2007;22:1301-1308.
-
(2007)
Histol Histopathol
, vol.22
, pp. 1301-1308
-
-
Shen, J.K.1
Dong, A.2
Hackett, S.F.3
-
100
-
-
77949519072
-
Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat
-
Carr AJ, Vugler AA, Hikita ST, et al: Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS One 2009;4:e8152.
-
(2009)
PLoS One
, vol.4
, pp. e8152
-
-
Carr, A.J.1
Vugler, A.A.2
Hikita, S.T.3
-
101
-
-
79955372799
-
Comparison of FRPE and human embryonic stem cellderived RPE behavior on aged human Bruch's membrane
-
Sugino IK, Sun Q, Wang J, et al: Comparison of FRPE and human embryonic stem cellderived RPE behavior on aged human Bruch's membrane. Invest Ophthalmol Vis Sci 2011;52:4979-4997.
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 4979-4997
-
-
Sugino, I.K.1
Sun, Q.2
Wang, J.3
-
102
-
-
84857643783
-
Embryonic stem cell trials for macular degeneration: A preliminary report
-
Schwartz SD, Hubschman JP, Heilwell G, et al: Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 2012;379:713-720.
-
(2012)
Lancet
, vol.379
, pp. 713-720
-
-
Schwartz, S.D.1
Hubschman, J.P.2
Heilwell, G.3
-
103
-
-
84863795441
-
A method to enhance cell survival on Bruch's membrane in eyes affected by age and age-related macular degeneration
-
Sugino IK, Rapista A, Sun Q, et al: A method to enhance cell survival on Bruch's membrane in eyes affected by age and age-related macular degeneration. Invest Ophthalmol Vis Sci 2011;52:9598-9609.
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 9598-9609
-
-
Sugino, I.K.1
Rapista, A.2
Sun, Q.3
-
104
-
-
0042867290
-
Retinal remodeling triggered by photoreceptor degenerations
-
Jones BW, Watt CB, Frederick JM, et al: Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 2003;464:1-16.
-
(2003)
J Comp Neurol
, vol.464
, pp. 1-16
-
-
Jones, B.W.1
Watt, C.B.2
Frederick, J.M.3
-
105
-
-
78649527521
-
The challenge of immunogenicity in the quest for induced pluripotency
-
Fairchild PJ: The challenge of immunogenicity in the quest for induced pluripotency. Nat Rev Immunol 2010;10:868-875.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 868-875
-
-
Fairchild, P.J.1
|